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Sökning: WFRF:(Saha Amit) > Vaccine specific im...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003928naa a2200433 4500
001oai:gup.ub.gu.se/170632
003SwePub
008240528s2013 | |||||||||||000 ||eng|
0247 a https://gup.ub.gu.se/publication/1706322 URI
0247 a https://doi.org/10.1016/j.vaccine.2012.11.0492 DOI
040 a (SwePub)gu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Saha, Amit4 aut
2451 0a Vaccine specific immune response to an inactivated oral cholera vaccine and EPI vaccines in a high and low arsenic area in Bangladeshi children
264 1b Elsevier BV,c 2013
520 a Immune responses to the inactivated oral whole cell cholera toxin B (CTB) subunit cholera vaccine, Dukoral(®), as well as three childhood vaccines in the national immunization system were compared in children living in high and low arsenic contaminated areas in Bangladesh. In addition, serum complement factors C3 and C4 levels were evaluated among children in the two areas. VACCINATIONS: Toddlers (2-5 years) were orally immunized with two doses of Dukoral 14 days apart. Study participants had also received diphtheria, tetanus and measles vaccines according to the Expanded Program on Immunization (EPI) in Bangladesh. RESULTS: The mean level of arsenic in the urine specimens in the children of the high arsenic area (HAA, Shahrasti, Chandpur) was 291.8μg/L while the level was 6.60μg/L in the low arsenic area (LAA, Mirpur, Dhaka). Cholera specific vibriocidal antibody responses were significantly increased in the HAA (87%, P<0.001) and the LAA (75%, P<0.001) children after vaccination with Dukoral, but no differences were found between the two groups. Levels of CTB specific IgA and IgG antibodies were comparable between the two groups, whereas LPS specific IgA and IgG were higher in the LAA group, although response rates were comparable. Diphtheria and tetanus vaccine specific IgG responses were significantly higher in the HAA compared to the LAA group (P<0.001, P=0.048 respectively), whereas there were no differences in the measles specific IgG responses between the groups. Complement C3 and C4 levels in sera were higher in participants from the HAA than the LAA groups (P<0.001, P=0.049 respectively). CONCLUSIONS: The study demonstrates that the oral cholera vaccine as well as the EPI vaccines studied are immunogenic in children in high and low arsenic areas in Bangladesh. The results are encouraging for the potential use of cholera vaccines as well as the EPI vaccines in arsenic endemic areas.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng
653 a Arsenic
653 a Immunogenicity
653 a Dukoral
653 a EPI vaccines
653 a Complement factors C3 and C4
7001 a Chowdhury, Mohiul4 aut
7001 a Nazim, Mohammad4 aut
7001 a Alam, Mohammad Murshid4 aut
7001 a Ahmed, Tanvir,d 19704 aut
7001 a Hossain, Mohammad Bakhtiar4 aut
7001 a Hore, Samar Kumar4 aut
7001 a Sultana, Gazi Nurun Nahar4 aut
7001 a Svennerholm, Ann-Mari,d 1947u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology4 aut0 (Swepub:gu)xsannx
7001 a Qadri, Firdausi4 aut
7102 a Göteborgs universitetb Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi4 org
7730 t Vaccined : Elsevier BVg 31:4, s. 647-652q 31:4<647-652x 0264-410X
8564 8u https://gup.ub.gu.se/publication/170632
8564 8u https://doi.org/10.1016/j.vaccine.2012.11.049

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