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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003510naa a2200385 4500
001oai:DiVA.org:uu-470713
003SwePub
008220329s2022 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4707132 URI
0247 a https://doi.org/10.1245/s10434-022-11463-x2 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Choi, Woo Jin4 aut
2451 0a Systematic Review and Meta-Analysis of Prognostic Factors for Early Recurrence in Intrahepatic Cholangiocarcinoma After Curative-Intent Resection
264 c 2022-02-18
264 1b Springer Nature,c 2022
338 a print2 rdacarrier
520 a Background Recurrence rates of intrahepatic cholangiocarcinoma (iCCA) after curative hepatectomy are as high as 50% to 70%, and about half of these recurrences occur within 2 years. This systematic review aims to define prognostic factors (PFs) for early recurrence (ER, within 24 months) and 24-month disease-free survival (DFS) after curative-intent iCCA resections.Methods Systematic searching was performed from database inception to 14 January 2021. Duplicate independent review and data extraction were performed. Data on 13 predefined PFs were collected. Meta-analysis was performed on PFs for ER and summarized using forest plots. The Quality in Prognostic Factor Studies tool was used for risk-of-bias assessment.Results The study enrolled 10 studies comprising 4158 patients during an accrual period ranging from 1990 to 2016. In the risk-of-bias assessment of patients who experienced ER after curative-intent iCCA resection, six studies were rated as low risk and four as moderate risk (49.6%; 95% confidence interval [CI], 49.2-50.0). Nine studies were pooled for meta-analysis. Of the postoperative PFs, multiple tumors, microvascular invasion, macrovascular invasion, lymph node metastasis, and R1 resection were associated with an increased hazard for ER or a reduced 24-month DFS, and the opposite was observed for receipt of adjuvant chemo/radiation therapy. Of the preoperative factors, cirrhosis, sex, HBV status were not associated with ER or 24-month DFS.Conclusion The findings from this systematic review could allow for improved surveillance, prognostication, and treatment decision-making for patients with resectable iCCAs. Further well-designed prospective studies are needed to explore prognostic factors for iCCA ER with a focus on preoperative variables.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kirurgi0 (SwePub)302122 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Surgery0 (SwePub)302122 hsv//eng
7001 a Williams, Phil J.4 aut
7001 a Claasen, Marco P. A. W.4 aut
7001 a Ivanics, Tommyu Uppsala universitet,Gastrointestinalkirurgi,Institutionen för medicinska vetenskaper4 aut0 (Swepub:uu)tomiv601
7001 a Englesakis, Marina4 aut
7001 a Gallinger, Steven4 aut
7001 a Hansen, Bettina4 aut
7001 a Sapisochin, Gonzalo4 aut
7102 a Uppsala universitetb Gastrointestinalkirurgi4 org
7730 t Annals of Surgical Oncologyd : Springer Natureg 29:7, s. 4337-4353q 29:7<4337-4353x 1068-9265x 1534-4681
8564 u https://link.springer.com/article/10.1245/s10434-022-11463-x#Ack1
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-470713
8564 8u https://doi.org/10.1245/s10434-022-11463-x

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