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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 05423naa a2201105 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:236229046 | |
| 003 | SwePub | |
| 008 | 240124s2023 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:153124002 | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:2362290462 URI |
| 024 | 7 | a https://doi.org/10.1183/13993003.00606-20222 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1531240022 URI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Khaleva, E4 aut |
| 245 | 1 0 | a Development of Core Outcome Measures sets for paediatric and adult Severe Asthma (COMSA) |
| 264 | c 2022-10-13 | |
| 264 | 1 | b European Respiratory Society (ERS),c 2023 |
| 506 | a gratis | |
| 520 | a Effectiveness studies with biological therapies for asthma lack standardised outcome measures. The COMSA (Core Outcome Measures sets for paediatric and adult Severe Asthma) working group sought to develop Core Outcome Measures (COM) sets to facilitate better synthesis of data and appraisal of biologics in paediatric and adult asthma clinical studies.MethodsCOMSA utilised a multi-stakeholder consensus process among patients with severe asthma, adult, and paediatric clinicians, pharmaceutical representatives and health regulators from across Europe. Evidence included a systematic review of development, validity, and reliability of selected outcome measures plus a narrative review and a pan-European survey to better understand patients’ and carers’ views about outcome measures. It was discussed using a modified GRADE Evidence to Decision framework. Anonymous voting was conducted using predefined consensus criteria.ResultsBoth adult and paediatric COM sets include forced expiratory volume in 1 s (FEV1) as z scores, annual frequency of severe exacerbations and maintenance oral corticosteroid use. Additionally, the paediatric COM set includes the Paediatric Asthma Quality of Life Questionnaire, and Asthma Control Test (ACT) or Childhood-ACT while the adult COM includes the Severe Asthma Questionnaire and the Asthma Control Questionnaire-6 (symptoms and rescue medication use reported separately).ConclusionsThis patient-centred collaboration has produced two COM sets for paediatric and adult severe asthma. It is expected that they will inform the methodology of future clinical trials, enhance comparability of efficacy and effectiveness of biological therapies, and help assess their socioeconomic value. COMSA will inform definitions of non-response and response to biological therapy for severe asthma. | |
| 700 | 1 | a Rattu, A4 aut |
| 700 | 1 | a Brightling, C4 aut |
| 700 | 1 | a Bush, A4 aut |
| 700 | 1 | a Bossios, Au Karolinska Institutet4 aut |
| 700 | 1 | a Bourdin, A4 aut |
| 700 | 1 | a Chung, KF4 aut |
| 700 | 1 | a Chaudhuri, R4 aut |
| 700 | 1 | a Coleman, C4 aut |
| 700 | 1 | a Dahlén, SEu Karolinska Institutet4 aut |
| 700 | 1 | a Djukanovic, R4 aut |
| 700 | 1 | a Deschildre, A4 aut |
| 700 | 1 | a Fleming, L4 aut |
| 700 | 1 | a Fowler, SJ4 aut |
| 700 | 1 | a Gupta, A4 aut |
| 700 | 1 | a Hamelmann, E4 aut |
| 700 | 1 | a Hashimoto, S4 aut |
| 700 | 1 | a Hedlin, Gu Karolinska Institutet4 aut |
| 700 | 1 | a Koppelman, GH4 aut |
| 700 | 1 | a Melén, Eu Karolinska Institutet4 aut |
| 700 | 1 | a Murray, CS4 aut |
| 700 | 1 | a Pilette, C4 aut |
| 700 | 1 | a Porsbjerg, C4 aut |
| 700 | 1 | a Pike, KC4 aut |
| 700 | 1 | a Rusconi, F4 aut |
| 700 | 1 | a Williams, C4 aut |
| 700 | 1 | a Ahrens, B4 aut |
| 700 | 1 | a Alter, P4 aut |
| 700 | 1 | a Anckers, F4 aut |
| 700 | 1 | a van den Berge, M4 aut |
| 700 | 1 | a Blumchen, K4 aut |
| 700 | 1 | a Brusselle, G4 aut |
| 700 | 1 | a Clarke, GW4 aut |
| 700 | 1 | a Cunoosamy, D4 aut |
| 700 | 1 | a Dahlén, Bu Karolinska Institutet4 aut |
| 700 | 1 | a Dixey, P4 aut |
| 700 | 1 | a Exley, A4 aut |
| 700 | 1 | a Frey, U4 aut |
| 700 | 1 | a Gaillard, EA4 aut |
| 700 | 1 | a Giovannini-Chami, L4 aut |
| 700 | 1 | a Grigg, J4 aut |
| 700 | 1 | a Hartenstein, D4 aut |
| 700 | 1 | a Heaney, LG4 aut |
| 700 | 1 | a Karadag, B4 aut |
| 700 | 1 | a Kaul, S4 aut |
| 700 | 1 | a Kull, Iu Karolinska Institutet4 aut |
| 700 | 1 | a Licari, A4 aut |
| 700 | 1 | a Maitland-van der Zee, AH4 aut |
| 700 | 1 | a Mahler, V4 aut |
| 700 | 1 | a Schoos, AM4 aut |
| 700 | 1 | a Nagakumar, P4 aut |
| 700 | 1 | a Negus, J4 aut |
| 700 | 1 | a Nielsen, H4 aut |
| 700 | 1 | a Paton, J4 aut |
| 700 | 1 | a Pijnenburg, M4 aut |
| 700 | 1 | a Ramiconi, V4 aut |
| 700 | 1 | a Romagosa Vilarnau, S4 aut |
| 700 | 1 | a Principe, S4 aut |
| 700 | 1 | a Rutjes, N4 aut |
| 700 | 1 | a Saglani, S4 aut |
| 700 | 1 | a Seddon, P4 aut |
| 700 | 1 | a Singer, F4 aut |
| 700 | 1 | a Staudinger, H4 aut |
| 700 | 1 | a Turner, S4 aut |
| 700 | 1 | a Vijverberg, S4 aut |
| 700 | 1 | a Winders, T4 aut |
| 700 | 1 | a Yasinska, Vu Karolinska Institutet4 aut |
| 700 | 1 | a Roberts, G4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t The European respiratory journald : European Respiratory Society (ERS)g 61:4q 61:4x 1399-3003x 0903-1936 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:236229046 |
| 856 | 4 8 | u https://doi.org/10.1183/13993003.00606-2022 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:153124002 |
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- Khaleva, E
- Rattu, A
- Brightling, C
- Bush, A
- Bossios, A
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- Chung, KF
- Chaudhuri, R
- Coleman, C
- Dahlén, SE
- Djukanovic, R
- Deschildre, A
- Fleming, L
- Fowler, SJ
- Gupta, A
- Hamelmann, E
- Hashimoto, S
- Hedlin, G
- Koppelman, GH
- Melén, E
- Murray, CS
- Pilette, C
- Porsbjerg, C
- Pike, KC
- Rusconi, F
- Williams, C
- Ahrens, B
- Alter, P
- Anckers, F
- van den Berge, M
- Blumchen, K
- Brusselle, G
- Clarke, GW
- Cunoosamy, D
- Dahlén, B
- Dixey, P
- Exley, A
- Frey, U
- Gaillard, EA
- Giovannini-Chami ...
- Grigg, J
- Hartenstein, D
- Heaney, LG
- Karadag, B
- Kaul, S
- Kull, I
- Licari, A
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- Mahler, V
- Schoos, AM
- Nagakumar, P
- Negus, J
- Nielsen, H
- Paton, J
- Pijnenburg, M
- Ramiconi, V
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- Principe, S
- Rutjes, N
- Saglani, S
- Seddon, P
- Singer, F
- Staudinger, H
- Turner, S
- Vijverberg, S
- Winders, T
- Yasinska, V
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