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Sökning: WFRF:(Sköld Karl) > An Automated Method...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003554naa a2200457 4500
001oai:DiVA.org:uu-95136
003SwePub
008061117s2007 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-951362 URI
0247 a https://doi.org/10.1021/pr060676e2 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Kaplan, Anders4 aut
2451 0a An Automated Method for Scanning LC−MS Data Sets for Significant Peptides and Proteins, Including Quantitative Profiling and Interactive Confirmation :b An Automated Method for Scanning LC−MS Data Sets for Significant Peptides and Proteins, Including Quantitative Profiling and Interactive Confirmation
264 c 2007-06-09
264 1b American Chemical Society (ACS),c 2007
338 a print2 rdacarrier
520 a Differential quantification of proteins and peptides by LC-MS is a promising method to acquire knowledge about biological processes, and for finding drug targets and biomarkers. However, differential protein analysis using LC-MS has been held back by the lack of suitable software tools. Large amounts of experimental data are easily generated in protein and peptide profiling experiments, but data analysis is time-consuming and labor-intensive. Here, we present a fully automated method for scanning LC-MS/MS data for biologically significant peptides and proteins, including support for interactive confirmation and further profiling. By studying peptide mixtures of known composition, we demonstrate that peptides present in different amounts in different groups of samples can be automatically screened for using statistical tests. A linear response can be obtained over almost 3 orders of magnitude, facilitating further profiling of peptides and proteins of interest. Furthermore, we apply the method to study the changes of endogenous peptide levels in mouse brain striatum after administration of reserpine, a classical model drug for inducing Parkinson disease symptoms.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmaceutiska vetenskaper0 (SwePub)301012 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmaceutical Sciences0 (SwePub)301012 hsv//eng
653 a LC-MS; quantitation; differential display; neuropeptides; DeCyder MS; label-free quantitation
653 a PHARMACY
653 a FARMACI
7001 a Söderström, Malin4 aut
7001 a Fenyö, David4 aut
7001 a Nilsson, Annau Uppsala universitet,MMS, medicinsk masspektrometri4 aut
7001 a Fälth, Mariau Uppsala universitet,MMS, medicinsk masspektrometri4 aut
7001 a Sköld, Karlu Uppsala universitet,MMS, medicinsk masspektrometri4 aut
7001 a Svensson, Marcusu Uppsala universitet,MMS, medicinsk masspektrometri4 aut
7001 a Pettersen, Harald4 aut
7001 a Lindqvist, Staffan4 aut
7001 a Svenningsson, Per4 aut
7001 a Andrén, Per E.u Uppsala universitet,MMS, medicinsk masspektrometri4 aut0 (Swepub:uu)perandre
7001 a Björkesten, Lennart4 aut
7102 a Uppsala universitetb MMS, medicinsk masspektrometri4 org
7730 t Journal of Proteome Researchd : American Chemical Society (ACS)g 6:7, s. 2888-2895q 6:7<2888-2895x 1535-3893x 1535-3907
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-95136
8564 8u https://doi.org/10.1021/pr060676e

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