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Arrest of haemorrha...
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Zoucas, EvitaLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups
(författare)
Arrest of haemorrhage at experimental liver trauma by intra-portal infusion of nor-epinephrine
- Artikel/kapitelEngelska1989
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Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:cf7b0d56-32ee-47a7-be0b-a5bd9ac839bb
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https://lup.lub.lu.se/record/8053387URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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The efficacy of intraportal (i.p.) nor-epinephrine infusion in controlling bleeding upon liver trauma in the presence of normal as well as defective platelet function was evaluated in the rat. Infusion of nor-epinephrine (10-4 M, NE) took place after cannulation of the gastro-duodenal vein, during 5 min prior to liver trauma. Simultaneously blood pressure (BP) was registered. Platelet aggregation was rendered defective by per os administration of acetyl-salicylic acid (2.5 mg/100 g bW ASA) 30 min prior to liver trauma. Liver trauma constituted of a standardized liver resection involving 2-3 per cent of the total liver weight, bleeding time and blood loss from the wound being registered. Haemoglobin (Hb), Haematocrit (Hct), platelet count (PC), APT-time and platelet aggregation were studied upon resection. I.p. infusion of NE resulted in significant increase of BP from 122.5 3.2 mm Hg in controls to 166.2 ± 3.2 mm Hg. NE infusion significantly decreased bleeding time at liver trauma from 270 ± 15 sec in controls to 154 ± 10 sec. Simultaneously blood-loss was decreased from 0.9 ± 0.1 g to 0.4 ± 0.1 gr. Administration of ASA increased bleeding time to 513 ± 17 sec and blood loss to 2.1 ± 0.1 gr. Infusion of NE in ASA pretreated rats reduced bleeding time to 253 ± 24 sec and blood loss to 1.1 ± 0.2 gr compared with animals receiving only ASA. Hb, Hct, PC and APT-time were not affected. Platelet aggregation was diminished after administration of ASA, but was not affected by NE.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Steen, StigLund University,Lunds universitet,Thoraxkirurgi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Thoracic Surgery,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)thor-sst
(författare)
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Bengmark, StigLund University,Lunds universitet,Kirurgi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Surgery (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)kir-sbe
(författare)
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KirurgiForskargrupper vid Lunds universitet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Surgical Research Communications7:1, s. 19-250882-9233
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