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Importance of resec...
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Ostrand, EmilSkane Univ Hosp, Sweden; Lund Univ, Sweden
(författare)
Importance of resection margin after resection of colorectal liver metastases in the era of modern chemotherapy: population-based cohort study
- Artikel/kapitelEngelska2024
Förlag, utgivningsår, omfång ...
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OXFORD UNIV PRESS,2024
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-203564
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-203564URI
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https://doi.org/10.1093/bjsopen/zrae035DOI
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Funding Agencies|Erik och Angelica Sparres forskningsstiftelse (EO)
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Background Resection margin has been associated with overall survival following liver resection for colorectal liver metastasis. The aim of this study was to examine how resection margins of 0.0 mm, 0.1-0.9 mm and >= 1 mm influence overall survival in patients resected for colorectal liver metastasis in a time of modern perioperative chemotherapy and surgery. Methods Using data from the national registries Swedish Colorectal Cancer Registry and Swedish National Quality Registry for Liver, Bile Duct and Gallbladder Cancer, patients that had liver resections for colorectal liver metastasis between 2009 and 2013 were included. In patients with a narrow or unknown surgical margin the original pathological reports were re-reviewed. Factors influencing overall survival were analysed using a Cox proportional hazard model. Results A total of 754 patients had a known margin status, of which 133 (17.6%) patients had a resection margin <1 mm. The overall survival in patients with a margin of 0 mm or 0.1-0.9 mm was 42 (95% c.i. 31 to 53) and 48 (95% c.i. 35 to 62) months respectively, compared with 75 (95% c.i. 65 to 85) for patients with >= 1 mm margin, P < 0.001. Margins of 0 mm or 0.1-0.9 mm were associated with poor overall survival in the multivariable analysis, HR 1.413 (95% c.i. 1.030 to 1.939), P = 0.032, and 1.399 (95% c.i. 1.025 to 1.910), P = 0.034, respectively. Conclusions Despite modern chemotherapy the resection margin is still an important factor for the survival of patients resected for colorectal liver metastasis, and a margin of >= 1 mm is needed to achieve the best possible outcome.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Rystedt, JennySkane Univ Hosp, Sweden; Lund Univ, Sweden
(författare)
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Engstrand, JennieKarolinska Univ Hosp, Sweden; Karolinska Inst, Sweden
(författare)
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Fruhling, PetterAkad Univ Hosp, Sweden; Uppsala Univ, Sweden
(författare)
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Hemmingsson, OskarUmea Univ, Sweden
(författare)
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Sandström, PerLinköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US(Swepub:liu)persa07
(författare)
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Eilard, Malin SternbySahlgrens Univ Hosp, Sweden; Univ Gothenburg, Sweden
(författare)
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Tingstedt, BobbySkane Univ Hosp, Sweden; Lund Univ, Sweden
(författare)
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Buchwald, PamelaSkane Univ Hosp, Sweden; Lund Univ, Sweden
(författare)
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Skane Univ Hosp, Sweden; Lund Univ, SwedenKarolinska Univ Hosp, Sweden; Karolinska Inst, Sweden
(creator_code:org_t)
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Ingår i:BJS Open: OXFORD UNIV PRESS8:32474-9842
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