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Sökning: WFRF:(Stuart C) > (2005-2009) > Regulation of alter...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003757naa a2200361 4500
001oai:lup.lub.lu.se:aae7bacc-eb05-4f63-8755-cbe03579f9a8
003SwePub
008160401s2008 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/11986252 URI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a MacKinnon, Alison C4 aut
2451 0a Regulation of alternative macrophage activation by galectin-3
264 1c 2008
520 a Alternative macrophage activation is implicated in diverse disease pathologies such as asthma, organ fibrosis, and granulomatous diseases, but the mechanisms underlying macrophage programming are not fully understood. Galectin-3 is a carbohydrate-binding lectin present on macrophages. We show that disruption of the galectin-3 gene in 129sv mice specifically restrains IL-4/IL-13-induced alternative macrophage activation in bone marrow-derived macrophages in vitro and in resident lung and recruited peritoneal macrophages in vivo without affecting IFN-gamma/LPS-induced classical activation or IL-10-induced deactivation. IL-4-mediated alternative macrophage activation is inhibited by siRNA-targeted deletion of galectin-3 or its membrane receptor CD98 and by inhibition of PI3K. Increased galectin-3 expression and secretion is a feature of alternative macrophage activation. IL-4 stimulates galectin-3 expression and release in parallel with other phenotypic markers of alternative macrophage activation. By contrast, classical macrophage activation with LPS inhibits galectin-3 expression and release. Galectin-3 binds to CD98, and exogenous galectin-3 or cross-linking CD98 with the mAb 4F2 stimulates PI3K activation and alternative activation. IL-4-induced alternative activation is blocked by bis-(3-deoxy-3-(3-methoxybenzamido)-beta-D-galactopyranosyl) sulfane, a specific inhibitor of extracellular galectin-3 carbohydrate binding. These results demonstrate that a galectin-3 feedback loop drives alternative macrophage activation. Pharmacological modulation of galectin-3 function represents a novel therapeutic strategy in pathologies associated with alternatively activated macrophages.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng
7001 a Farnworth, Sarah L4 aut
7001 a Hodkinson, Philip S4 aut
7001 a Henderson, Neil C4 aut
7001 a Atkinson, Kirsten M4 aut
7001 a Leffler, Hakonu Lund University,Lunds universitet,Avdelningen för mikrobiologi, immunologi och glykobiologi - MIG,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Microbiology, Immunology and Glycobiology - MIG,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)mmb-hle
7001 a Nilsson, Ulfu Lund University,Lunds universitet,Centrum för analys och syntes,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Centre for Analysis and Synthesis,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)ok2-uni
7001 a Haslett, Christopher4 aut
7001 a Forbes, Stuart J4 aut
7001 a Sethi, Tariq4 aut
7102 a Avdelningen för mikrobiologi, immunologi och glykobiologi - MIGb Institutionen för laboratoriemedicin4 org
7730 t Journal of Immunologyg 180:4, s. 2650-2658q 180:4<2650-2658x 1550-6606
8564 u http://www.jimmunol.org/cgi/content/full/180/4/2650y FULLTEXT
8564 8u https://lup.lub.lu.se/record/1198625

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