Menopausal hormone therapy and breast cancer risk: effect modification by body mass through life

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Sandvei, Marie SøftelandNorwegian Univ Sci & Technol, Fac Med & Hlth Sci, Dept Publ Hlth & Nursing, Trondheim, Norway; Nordland Hosp Bodo, Dept Canc & Palliat Care, Bodo, Norway; Univ Tromso, Dept Clin Med, Tromso, Norway (författare)

Menopausal hormone therapy and breast cancer risk : effect modification by body mass through life

Artikel/kapitelEngelska2019

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2018-08-06
Springer Science and Business Media LLC,2019
printrdacarrier

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LIBRIS-ID:oai:DiVA.org:uu-383003
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-383003URI
https://doi.org/10.1007/s10654-018-0431-7DOI

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Språk:engelska
Sammanfattning på:engelska

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It is not known whether increased breast cancer risk caused by menopausal hormone therapy (HT) depends on body mass patterns through life. In a prospective study of 483,241 Norwegian women aged 50–69 years at baseline, 7656 women developed breast cancer during follow-up (2006–2013). We combined baseline information on recalled body mass in childhood/adolescence and current (baseline) body mass index (BMI) to construct mutually exclusive life-course body mass patterns. We assessed associations of current HT use with breast cancer risk according to baseline BMI and life-course patterns of body mass, and estimated relative excess risk due to interaction (RERI). Within all levels of baseline BMI, HT use was associated with increased risk. Considering life-course body mass patterns as a single exposure, we used women who “remained at normal weight” through life as the reference, and found that being “overweight as young” was associated with lower risk (hazard ratio (HR) 0.85, 95% confidence interval (CI) 0.76–0.94), whereas women who “gained weight” had higher risk (HR 1.20, 95% CI 1.12–1.28). Compared to never users of HT who were “overweight as young”, HT users who either “remained at normal weight” or “gained weight” in adulthood were at higher risk than expected when adding the separate risks (RERI 0.52, 95% CI 0.09–0.95, and RERI 0.37, 95% CI − 0.07–0.80), suggesting effect modification. Thus, we found that women who remain at normal weight or gain weight in adulthood may be more susceptible to the risk increasing effect of HT compared to women who were overweight as young.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Public Health, Global Health, Social Medicine and Epidemiology hsv//eng
Breast cancer
Menopausal hormone therapy
Body-mass index
Epidemiology
Cohort study

Biuppslag (personer, institutioner, konferenser, titlar ...)

Vatten, Lars J.Norwegian Univ Sci & Technol, Fac Med & Hlth Sci, Dept Publ Hlth & Nursing, Trondheim, Norway (författare)
Bjelland, Elisabeth KreftingUppsala universitet,Allmänmedicin och preventivmedicin,Akershus Univ Hosp, Dept Obstet & Gynecol, Lorenskog, Norway(Swepub:uu)elibj674 (författare)
Eskild, AnneAkershus Univ Hosp, Dept Obstet & Gynecol, Lorenskog, Norway; Univ Oslo, Inst Clin Med, Campus Ahus, Oslo, Norway (författare)
Hofvind, SolveigCanc Registry Norway, Inst Populat Based Res, Oslo, Norway (författare)
Ursin, GiskeCanc Registry Norway, Inst Populat Based Res, Oslo, Norway; Univ Oslo, Inst Basic Med Sci, Oslo, Norway; Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA USA (författare)
Opdahl, SigneNorwegian Univ Sci & Technol, Fac Med & Hlth Sci, Dept Publ Hlth & Nursing, Trondheim, Norway (författare)
Norwegian Univ Sci & Technol, Fac Med & Hlth Sci, Dept Publ Hlth & Nursing, Trondheim, Norway; Nordland Hosp Bodo, Dept Canc & Palliat Care, Bodo, Norway; Univ Tromso, Dept Clin Med, Tromso, NorwayNorwegian Univ Sci & Technol, Fac Med & Hlth Sci, Dept Publ Hlth & Nursing, Trondheim, Norway (creator_code:org_t)

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Ingår i:European Journal of Epidemiology: Springer Science and Business Media LLC34:3, s. 267-2780393-29901573-7284

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Av författaren/redakt...: Sandvei, Marie S ...; Vatten, Lars J.; Bjelland, Elisab ...; Eskild, Anne; Hofvind, Solveig; Ursin, Giske; visa fler...; Opdahl, Signe; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Hälsovetenskap; och Folkhälsovetensk ...

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