WFRF:(Wakamatsu Kazumasa)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02704naa a2200325 4500 | |
| 001 | oai:DiVA.org:liu-35866 | |
| 003 | SwePub | |
| 008 | 091010s2006 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-358662 URI |
| 024 | 7 | a https://doi.org/10.1111/j.1600-0749.2006.00296.x2 DOI |
| 040 | a (SwePub)liu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Wakamatsu, Kazumasa4 aut |
| 245 | 1 0 | a Determination of eumelanin in human urine |
| 264 | 1 | b Wiley,c 2006 |
| 338 | a print2 rdacarrier | |
| 520 | a Normal and malignant melanocytes produce melanins and melanin-related metabolites, most of which are retained in the cells but some are secreted into the blood and then excreted in the urine. In this study, we developed a method to measure levels of eumelanin in urine samples and evaluated its clinical significance in comparison with the melanin-related metabolites 6-hydroxy-5-methoxyindole-2-carboxylic acid (6H5MI2C) and 5-S-cysteinyldopa (5-S-CD), and with pheomelanin, measured after degradation as 4-amino-3-hydroxyphenylalanine (4-AHP). The method is based on the production of pyrrole-2,3,5-tricarboxylic acid (PTCA) on permanganate oxidation of eumelanin, followed by quantification by liquid chromatography. For 118 urine samples from 10 control subjects, mean urinary excretions of PTCA, 6H5MI2C, 5-S-CD and 4-AHP were 19, 67, 37 and 59 μmol/mol creatinine respectively. In melanoma patients (n = 45), the mean urinary excretions of PTCA, 6H5MI2C, 5-S-CD, and 4-AHP were 91, 926, 4070 and 3530 μmol/mol creatinine respectively. Median level of PTCA in melanoma patients was elevated 2.1-fold compared with control subjects. The degrees of elevation for 6H5MI2C, 5-S-CD, and 4-AHP were 1.8-, 22- and 6.2-fold respectively. Thus, although urinary PTCA is of little clinical value in following the progression of melanoma, urinary 4-AHP appears to be of considerable value in this respect. © 2006 Blackwell Munksgaard. | |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 700 | 1 | a Takasaki, Akihiko4 aut |
| 700 | 1 | a Kågedal, Bertil,d 1943-u Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Avdelningen för klinisk kemi,Klinisk kemi4 aut0 (Swepub:liu)berka70 |
| 700 | 1 | a Kageshita, Toshiro4 aut |
| 700 | 1 | a Ito, Shosuke4 aut |
| 710 | 2 | a Linköpings universitetb Hälsouniversitetet4 org |
| 773 | 0 | t Pigment Cell Researchd : Wileyg 19:2, s. 163-169q 19:2<163-169x 0893-5785x 1600-0749 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-35866 |
| 856 | 4 8 | u https://doi.org/10.1111/j.1600-0749.2006.00296.x |
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