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Why mitochondria ne...
Why mitochondria need a genome revisited
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- Björkholm, Patrik (författare)
- Uppsala universitet,Molekylär evolution
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- Ernst, Andreas M. (författare)
- Yale Univ, Sch Med, Dept Cell Biol, New Haven, CT 06510 USA.
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- Hagström, Erik (författare)
- Uppsala universitet,Molekylär evolution
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- Andersson, Siv G. E. (författare)
- Uppsala universitet,Molekylär evolution
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(creator_code:org_t)
- 2016-12-20
- 2017
- Engelska.
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Ingår i: FEBS Letters. - : WILEY-BLACKWELL. - 0014-5793 .- 1873-3468. ; 591:1, s. 65-75
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- In this paper, we experimentally address the debate about why functional transfer of mitochondrial genes to the nucleus has been halted in some organismal groups and why cytosolic expression of mitochondrial proteins has proven remarkably difficult. By expressing all 13 human mitochondrial-encoded genes with strong mitochondrial-targeting sequences in the cytosol of human cells, we show that all proteins, except ATP8, are transported to the endoplasmic reticulum (ER). These results confirm and extend previous findings based on three mitochondrial genes lacking mitochondrial-targeting sequences that also were relocated to the ER during cytosolic expression. We conclude that subcellular protein targeting constitutes a major barrier to functional transfer of mitochondrial genes to the nuclear genome.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Nyckelord
- endoplasmic reticulum
- hydrophobicity
- mitochondria
- signal recognition particle
- transmembrane domain
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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