onr:"20194927"
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- Päären, Aivar1965- (författare)
Early risk factors for adult bipolar disorder in adolescents with mood disorders A 15-year follow-up of a community sample
- E-artikel/E-kapitelEngelska2014
Förlag, utgivningsår, omfång ...
- 2014
Nummerbeteckningar
- LIBRIS-ID:20194927
- http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-239832uri
- urn:nbn:se:uu:diva-239832urn
- 10.1186/s12888-014-0363-zdoi
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- Språk:engelska
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Anmärkningar
- adolescents with mood disorders: A 15-year follow-up of a community sample
- Published
- gratis
- Background: We aimed to outline the early risk factors for adult bipolar disorder (BPD) in adolescents with mood disorders. Methods: Adolescents (16-17 years old) with mood disorders (n=287; 90 participants with hypomania spectrum episodes and 197 with major depressive disorder [MDD]) were identified from a community sample. Fifteen years later (at 30-33 years of age), mood episodes were assessed (n=194). The risk of developing BPD (n=22), compared with MDD (n=104) or no mood episodes in adulthood (n=68), was estimated via logistic regression. Adolescent mood symptoms, non-mood disorders, and family characteristics were assessed as potential risk factors. Results: Among the adolescents with mood disorders, a family history of BPD was the strongest predictor of developing BPD compared with having no mood episodes in adulthood (OR=5.94; 95% CI=1.11-31.73), whereas disruptive disorders significantly increased the risk of developing BPD compared with developing MDD (OR=2.94; CI=1.06-8.12). The risk that adolescents with MDD would develop adult BPD, versus having no mood episodes in adulthood, was elevated among those with an early disruptive disorder (OR=3.62; CI=1.09-12.07) or multiple somatic symptoms (OR=6.60; CI=1.70-25.67). Only disruptive disorders significantly predicted adult BPD among adolescents with MDD versus continued MDD in adulthood (OR=3.59; CI=1.17-10.97). Only a few adolescents with hypomania spectrum episodes continued to have BPD as adults, and anxiety disorders appeared to increase this risk. Conclusions : Although most of the identified potential risk factors are likely general predictors of continued mood disorders, disruptive disorders emerged as specific predictors of developing adult BPD among adolescents with MDD.
Ämnesord och genrebeteckningar
- Medical and Health Sciences hsv
- Clinical Medicine hsv
- Psychiatry hsv
- Medicin och hälsovetenskap hsv
- Klinisk medicin hsv
- Psykiatri hsv
- Psychiatry uu
- Psykiatri uu
- adolescent mood disorders
- bipolar disorder
- predictors
- long-term follow-up assessment
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Bohman, Hannes (författare)
- von Knorring, Lars (författare)
- Olsson, Gunilla (författare)
- von Knorring, Anne-Liis (författare)
- Jonsson, Ulf (författare)
- Uppsala universitetMedicinska och farmaceutiska vetenskapsområdet (utgivare)
- Uppsala universitetMedicinska och farmaceutiska vetenskapsområdet (utgivare)
Sammanhörande titlar
- Del av/supplement till:channel record
- Ingår i:VärdpublikationBMC Psychiatry14:1, 3631471-244X
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