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The ERK1/2 Signalin...
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Huang, PanPeking University, Peoples R China
(författare)
The ERK1/2 Signaling Pathway Is Involved in Sulfur Dioxide Preconditioning-Induced Protection against Cardiac Dysfunction in Isolated Perfused Rat Heart Subjected to Myocardial Ischemia/Reperfusion
- Artikel/kapitelEngelska2013
Förlag, utgivningsår, omfång ...
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2013-11-08
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MDPI,2013
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-103305
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-103305URI
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https://doi.org/10.3390/ijms141122190DOI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Ischemia/reperfusion injury (IRI) occurs frequently during reperfusion of ischemic myocardium, and preconditioning has been regarded as one of the best strategies to prevent myocardial injury during the ischemia/reperfusion process. Our previous studies indicated that a small dose of sulfur dioxide (SO2) used as preconditioning exerts cardioprotection. However, the mechanisms underlying the cardioprotection remain unclear. The present study was designed to examine if the extracellular regulated protein kinases 1/2 (ERK1/2) signaling pathway mediated protection against cardiac dysfunction after SO2 preconditioning in isolated rat hearts subjected to ischemia/reperfusion (I/R). Langendorff heart perfusion was performed in vitro, where 56 male Wistar rats were randomly divided into seven groups: control group, 5 mol/L SO2 group (S5), 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one (PD98059) + 5 mol/L SO2 (PD98059 + S5) group, PD98059 group, I/R group, 5 mol/L SO2 + I/R (S5 + I/R) group and PD98059 + 5 mol/L SO2 + I/R (PD98059 + S5 + I/R) group. Cardiac function and myocardial phosphorylated ERK1/2 protein were measured. We found that I/R in isolated rat heart resulted in cardiac dysfunction with a significant increase in phosphorylated ERK1/2 protein. SO2 preconditioning markedly suppressed phosphorylated ERK1/2 protein and improved cardiac function in isolated rat heart with I/R (p less than 0.05). However, pre-treatment with PD98059 could prevent the above effects of SO2 preconditioning. In conclusion, SO2 preconditioning protected against cardiac dysfunction in isolated rat heart subjected to I/R via suppression of the over-activation of the ERK1/2 signaling pathway.
Ämnesord och genrebeteckningar
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myocardial ischemia; reperfusion injury; sulfur dioxide; preconditioning; mitogen activated protein kinase
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MEDICINE
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MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Sun, YanPeking University, Peoples R China
(författare)
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Yang, JinyanPeking University, Peoples R China
(författare)
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Chen, SiyaoPeking University, Peoples R China
(författare)
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Dong Liu, AngieLinköpings universitet,Institutionen för medicin och hälsa,Hälsouniversitetet
(författare)
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Holmberg, LukasLinköpings universitet,Institutionen för medicin och hälsa,Hälsouniversitetet
(författare)
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Huang, XiaomeiPeking University, Peoples R China
(författare)
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Tang, ChaoshuMinist Educ, Peoples R China Peking University, Peoples R China
(författare)
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Du, JunbaoPeking University, Peoples R China Minist Educ, Peoples R China
(författare)
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Jin, HongfangPeking University, Peoples R China Minist Educ, Peoples R China
(författare)
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Peking University, Peoples R ChinaInstitutionen för medicin och hälsa
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:International Journal of Molecular Sciences: MDPI14:11, s. 22190-222011661-65961422-0067
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Till lärosätets databas
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Huang, Pan
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Sun, Yan
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Yang, Jinyan
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Chen, Siyao
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Dong Liu, Angie
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Holmberg, Lukas
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visa fler...
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Huang, Xiaomei
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Tang, Chaoshu
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Du, Junbao
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Jin, Hongfang
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visa färre...
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Linköpings universitet