SwePub
Tyck till om SwePub Sök här!
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:DiVA.org:uu-113895"
 

Search: onr:"swepub:oai:DiVA.org:uu-113895" > Clinical trial enro...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Sorbye, Halfdan (author)

Clinical trial enrollment, patient characteristics, and survival differences in prospectively registered metastatic colorectal cancer patients

  • Article/chapterEnglish2009

Publisher, publication year, extent ...

  • Wiley,2009
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-113895
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-113895URI
  • https://doi.org/10.1002/cncr.24527DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:119448666URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • BACKGROUND: Trial accrual patterns were examined to determine whether metastatic colorectal cancer (mCRC) patients enrolled in trials are representative of a general cancer population concerning patient characteristics and survival. METHODS: A total of 760 mCRC patients referred for their first oncological consideration at 3 hospitals in Scandinavia covering defined populations were registered consecutively during 2003 to 2006. Clinical trial enrollment, patient characteristics, and treatment were recorded prospectively, and the follow-up was complete. RESULTS: Palliative chemotherapy was initiated in 61% of the patients. Approximately one-third (36%) of patients receiving chemotherapy were included in a trial. The main reason for nonparticipation was failed eligibility criteria (69%). The median survival after chemotherapy was 15.8 months for all patients, and 18 months after combination chemotherapy. Trial patients had better prognostic characteristics and significantly longer survival than nontrial patients: 21.3 months versus 15.2 months when receiving combination chemotherapy. Poor performance status was the main reason for giving best supportive care only, and the median survival was then only 2.1 months. The median survival for all 760 nonresectable mCRC patients was 10.7 months. CONCLUSIONS: mCRC patients enrolled into clinical trials differ in characteristics from patients receiving chemotherapy outside protocol and have better survival, even when given the same treatment. Although trial patients have a median survival close to 2 years, survival is lower for all patients receiving chemotherapy and much lower for all patients diagnosed with mCRC. Studies that better accept the heterogeneity of the population with mCRC are needed.

Subject headings and genre

  • MEDICINE
  • MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

  • Pfeiffer, Per (author)
  • Cavalli-Björkman, Nina,1970-Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi (author)
  • Qvortrup, Camilla (author)
  • Holsen, Mari H. (author)
  • Wentzel-Larsen, Tore (author)
  • Glimelius, BengtKarolinska Institutet,Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi(Swepub:uu)bengglim (author)
  • Uppsala universitetInstitutionen för onkologi, radiologi och klinisk immunologi (creator_code:org_t)

Related titles

  • In:Cancer: Wiley115:20, s. 4679-870008-543X1097-0142

Internet link

Find in a library

  • Cancer (Search for host publication in LIBRIS)

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view