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  • Mikkelsen, Tarjei S (author)

Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences

  • Article/chapterEnglish2007

Publisher, publication year, extent ...

  • Springer Science and Business Media LLC,2007
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-15798
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-15798URI
  • https://doi.org/10.1038/nature05805DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • We report a high-quality draft of the genome sequence of the grey, short-tailed opossum (Monodelphis domestica). As the first metatherian ('marsupial') species to be sequenced, the opossum provides a unique perspective on the organization and evolution of mammalian genomes. Distinctive features of the opossum chromosomes provide support for recent theories about genome evolution and function, including a strong influence of biased gene conversion on nucleotide sequence composition, and a relationship between chromosomal characteristics and X chromosome inactivation. Comparison of opossum and eutherian genomes also reveals a sharp difference in evolutionary innovation between protein-coding and non-coding functional elements. True innovation in protein-coding genes seems to be relatively rare, with lineage-specific differences being largely due to diversification and rapid turnover in gene families involved in environmental interactions. In contrast, about 20% of eutherian conserved non-coding elements (CNEs) are recent inventions that postdate the divergence of Eutheria and Metatheria. A substantial proportion of these eutherian-specific CNEs arose from sequence inserted by transposable elements, pointing to transposons as a major creative force in the evolution of mammalian gene regulation.

Subject headings and genre

  • Animals
  • Base Composition
  • Conserved Sequence/genetics
  • DNA Transposable Elements/genetics
  • Evolution; Molecular
  • Genome/*genetics
  • Genomics
  • Humans
  • Opossums/*genetics
  • Polymorphism; Single Nucleotide/genetics
  • Protein Biosynthesis
  • Synteny/genetics
  • X Chromosome Inactivation/genetics
  • MEDICINE
  • MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

  • Wakefield, Matthew J (author)
  • Aken, Bronwen (author)
  • Amemiya, Chris T (author)
  • Chang, Jean L (author)
  • Duke, Shannon (author)
  • Garber, Manuel (author)
  • Gentles, Andrew J (author)
  • Goodstadt, Leo (author)
  • Heger, Andreas (author)
  • Jurka, Jerzy (author)
  • Kamal, Michael (author)
  • Mauceli, Evan (author)
  • Searle, Stephen M J (author)
  • Sharpe, Ted (author)
  • Baker, Michelle L (author)
  • Batzer, Mark A (author)
  • Benos, Panayiotis V (author)
  • Belov, Katherine (author)
  • Clamp, Michele (author)
  • Cook, April (author)
  • Cuff, James (author)
  • Das, Radhika (author)
  • Davidow, Lance (author)
  • Deakin, Janine E (author)
  • Fazzari, Melissa J (author)
  • Glass, Jacob L (author)
  • Grabherr, Manfred (author)
  • Greally, John M (author)
  • Gu, Wanjun (author)
  • Hore, Timothy A (author)
  • Huttley, Gavin A (author)
  • Kleber, Michael (author)
  • Jirtle, Randy L (author)
  • Koina, Edda (author)
  • Lee, Jeannie T (author)
  • Mahony, Shaun (author)
  • Marra, Marco A (author)
  • Miller, Robert D (author)
  • Nicholls, Robert D (author)
  • Oda, Mayumi (author)
  • Papenfuss, Anthony T (author)
  • Parra, Zuly E (author)
  • Pollock, David D (author)
  • Ray, David A (author)
  • Schein, Jacqueline E (author)
  • Speed, Terence P (author)
  • Thompson, Katherine (author)
  • VandeBerg, John L (author)
  • Wade, Claire M (author)
  • Walker, Jerilyn A (author)
  • Waters, Paul D (author)
  • Webber, Caleb (author)
  • Weidman, Jennifer R (author)
  • Xie, Xiaohui (author)
  • Zody, Michael C (author)
  • Graves, Jennifer A Marshall (author)
  • Ponting, Chris P (author)
  • Breen, Matthew (author)
  • Samollow, Paul B (author)
  • Lander, Eric S (author)
  • Lindblad-Toh, KerstinUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi(Swepub:uu)kerli865 (author)
  • Uppsala universitetInstitutionen för medicinsk biokemi och mikrobiologi (creator_code:org_t)

Related titles

  • In:Nature: Springer Science and Business Media LLC447:7141, s. 167-1770028-08361476-4687

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