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Genome of the marsu...
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Mikkelsen, Tarjei S
(author)
Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences
- Article/chapterEnglish2007
Publisher, publication year, extent ...
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Springer Science and Business Media LLC,2007
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-15798
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-15798URI
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https://doi.org/10.1038/nature05805DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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We report a high-quality draft of the genome sequence of the grey, short-tailed opossum (Monodelphis domestica). As the first metatherian ('marsupial') species to be sequenced, the opossum provides a unique perspective on the organization and evolution of mammalian genomes. Distinctive features of the opossum chromosomes provide support for recent theories about genome evolution and function, including a strong influence of biased gene conversion on nucleotide sequence composition, and a relationship between chromosomal characteristics and X chromosome inactivation. Comparison of opossum and eutherian genomes also reveals a sharp difference in evolutionary innovation between protein-coding and non-coding functional elements. True innovation in protein-coding genes seems to be relatively rare, with lineage-specific differences being largely due to diversification and rapid turnover in gene families involved in environmental interactions. In contrast, about 20% of eutherian conserved non-coding elements (CNEs) are recent inventions that postdate the divergence of Eutheria and Metatheria. A substantial proportion of these eutherian-specific CNEs arose from sequence inserted by transposable elements, pointing to transposons as a major creative force in the evolution of mammalian gene regulation.
Subject headings and genre
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Animals
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Base Composition
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Conserved Sequence/genetics
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DNA Transposable Elements/genetics
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Evolution; Molecular
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Genome/*genetics
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Genomics
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Humans
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Opossums/*genetics
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Polymorphism; Single Nucleotide/genetics
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Protein Biosynthesis
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Synteny/genetics
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X Chromosome Inactivation/genetics
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MEDICINE
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MEDICIN
Added entries (persons, corporate bodies, meetings, titles ...)
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Wakefield, Matthew J
(author)
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Aken, Bronwen
(author)
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Amemiya, Chris T
(author)
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Chang, Jean L
(author)
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Duke, Shannon
(author)
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Garber, Manuel
(author)
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Gentles, Andrew J
(author)
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Goodstadt, Leo
(author)
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Heger, Andreas
(author)
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Jurka, Jerzy
(author)
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Kamal, Michael
(author)
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Mauceli, Evan
(author)
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Searle, Stephen M J
(author)
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Sharpe, Ted
(author)
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Baker, Michelle L
(author)
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Batzer, Mark A
(author)
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Benos, Panayiotis V
(author)
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Belov, Katherine
(author)
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Clamp, Michele
(author)
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Cook, April
(author)
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Cuff, James
(author)
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Das, Radhika
(author)
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Davidow, Lance
(author)
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Deakin, Janine E
(author)
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Fazzari, Melissa J
(author)
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Glass, Jacob L
(author)
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Grabherr, Manfred
(author)
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Greally, John M
(author)
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Gu, Wanjun
(author)
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Hore, Timothy A
(author)
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Huttley, Gavin A
(author)
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Kleber, Michael
(author)
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Jirtle, Randy L
(author)
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Koina, Edda
(author)
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Lee, Jeannie T
(author)
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Mahony, Shaun
(author)
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Marra, Marco A
(author)
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Miller, Robert D
(author)
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Nicholls, Robert D
(author)
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Oda, Mayumi
(author)
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Papenfuss, Anthony T
(author)
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Parra, Zuly E
(author)
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Pollock, David D
(author)
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Ray, David A
(author)
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Schein, Jacqueline E
(author)
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Speed, Terence P
(author)
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Thompson, Katherine
(author)
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VandeBerg, John L
(author)
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Wade, Claire M
(author)
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Walker, Jerilyn A
(author)
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Waters, Paul D
(author)
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Webber, Caleb
(author)
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Weidman, Jennifer R
(author)
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Xie, Xiaohui
(author)
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Zody, Michael C
(author)
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Graves, Jennifer A Marshall
(author)
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Ponting, Chris P
(author)
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Breen, Matthew
(author)
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Samollow, Paul B
(author)
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Lander, Eric S
(author)
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Lindblad-Toh, KerstinUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi(Swepub:uu)kerli865
(author)
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Uppsala universitetInstitutionen för medicinsk biokemi och mikrobiologi
(creator_code:org_t)
Related titles
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In:Nature: Springer Science and Business Media LLC447:7141, s. 167-1770028-08361476-4687
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- By the author/editor
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Mikkelsen, Tarje ...
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Wakefield, Matth ...
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Aken, Bronwen
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Amemiya, Chris T
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Chang, Jean L
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Duke, Shannon
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show more...
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Garber, Manuel
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Gentles, Andrew ...
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Goodstadt, Leo
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Heger, Andreas
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Jurka, Jerzy
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Kamal, Michael
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Mauceli, Evan
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Searle, Stephen ...
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Sharpe, Ted
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Baker, Michelle ...
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Batzer, Mark A
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Benos, Panayioti ...
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Belov, Katherine
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Clamp, Michele
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Cook, April
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Cuff, James
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Das, Radhika
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Davidow, Lance
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Deakin, Janine E
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Fazzari, Melissa ...
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Glass, Jacob L
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Grabherr, Manfre ...
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Greally, John M
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Gu, Wanjun
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Hore, Timothy A
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Huttley, Gavin A
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Kleber, Michael
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Jirtle, Randy L
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Koina, Edda
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Lee, Jeannie T
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Mahony, Shaun
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Marra, Marco A
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Miller, Robert D
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Nicholls, Robert ...
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Oda, Mayumi
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Papenfuss, Antho ...
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Parra, Zuly E
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Pollock, David D
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Ray, David A
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Schein, Jacqueli ...
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Speed, Terence P
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Thompson, Kather ...
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VandeBerg, John ...
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Wade, Claire M
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Walker, Jerilyn ...
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Waters, Paul D
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Webber, Caleb
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Weidman, Jennife ...
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Xie, Xiaohui
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Zody, Michael C
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Graves, Jennifer ...
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Ponting, Chris P
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Breen, Matthew
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Samollow, Paul B
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Lander, Eric S
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Lindblad-Toh, Ke ...
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Nature
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Uppsala University