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Association of Prot...
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Goodman, Shaun G.
(författare)
Association of Proton Pump Inhibitor Use on Cardiovascular Outcomes With Clopidogrel and Ticagrelor : Outcomes With Clopidogrel and Ticagrelor
- Artikel/kapitelEngelska2012
Förlag, utgivningsår, omfång ...
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-172047
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-172047URI
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https://doi.org/10.1161/CIRCULATIONAHA.111.032912DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Background-The clinical significance of the interaction between clopidogrel and proton pump inhibitors (PPIs) remains unclear. Methods and Results-We examined the relationship between PPI use and 1-year cardiovascular events (cardiovascular death, myocardial infarction, or stroke) in patients with acute coronary syndrome randomized to clopidogrel or ticagrelor in a prespecified, nonrandomized subgroup analysis of the Platelet Inhibition and Patient Outcomes (PLATO) trial. The primary end point rates were higher for individuals on a PPI (n = 6539) compared with those not on a PPI (n = 12 060) at randomization in both the clopidogrel (13.0% versus 10.9%; adjusted hazard ratio [HR], 1.20; 95% confidence interval [CI], 1.04 -1.38) and ticagrelor (11.0% versus 9.2%; HR, 1.24; 95% CI, 1.07-1.45) groups. Patients on non-PPI gastrointestinal drugs had similar primary end point rates compared with those on a PPI (PPI versus non-PPI gastrointestinal treatment: clopidogrel, HR, 0.98; 95% CI, 0.79-1.23; ticagrelor, HR, 0.89; 95% CI, 0.73-1.10). In contrast, patients on no gastric therapy had a significantly lower primary end point rate (PPI versus no gastrointestinal treatment: clopidogrel, HR, 1.29; 95% CI, 1.12-1.49; ticagrelor, HR, 1.30; 95% CI, 1.14-1.49). Conclusions-The use of a PPI was independently associated with a higher rate of cardiovascular events in patients with acute coronary syndrome receiving clopidogrel. However, a similar association was observed between cardiovascular events and PPI use during ticagrelor treatment and with other non-PPI gastrointestinal treatment. Therefore, in the PLATO trial, the association between PPI use and adverse events may be due to confounding, with PPI use more of a marker for, than a cause of, higher rates of cardiovascular events.
Ämnesord och genrebeteckningar
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acute coronary syndrome
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clopidogrel
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mortality
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myocardial infarction
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ticagrelor
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Clare, Robert
(författare)
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Pieper, Karen S.
(författare)
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Nicolau, Jose C.
(författare)
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Storey, Robert F.
(författare)
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Cantor, Warren J.
(författare)
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Mahaffey, Kenneth W.
(författare)
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Angiolillo, Dominick J.
(författare)
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Husted, Steen
(författare)
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Cannon, Christopher P.
(författare)
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James, Stefan K,1964-Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala kliniska forskningscentrum (UCR),Kardiologi(Swepub:uu)stjam367
(författare)
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Kilhamn, Jan
(författare)
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Steg, P. Gabriel
(författare)
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Harrington, Robert A.
(författare)
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Wallentin, Lars,1943-Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),kardiologi(Swepub:uu)larswall
(författare)
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Uppsala universitetInstitutionen för medicinska vetenskaper
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Circulation125:8, s. 978-9860009-73221524-4539
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Goodman, Shaun G ...
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Clare, Robert
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Pieper, Karen S.
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Nicolau, Jose C.
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Storey, Robert F ...
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Cantor, Warren J ...
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Mahaffey, Kennet ...
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Angiolillo, Domi ...
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Husted, Steen
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Cannon, Christop ...
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James, Stefan K, ...
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Kilhamn, Jan
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Steg, P. Gabriel
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Harrington, Robe ...
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Wallentin, Lars, ...
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- Artiklar i publikationen
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Circulation
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Uppsala universitet