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Ticagrelor vs. clop...
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Lindholm, DanielUppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
(författare)
Ticagrelor vs. clopidogrel in patients with non-ST-elevation acute coronary syndrome with or without revascularization : results from the PLATO trial
- Artikel/kapitelEngelska2014
Förlag, utgivningsår, omfång ...
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2014-04-11
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Oxford University Press (OUP),2014
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electronicrdacarrier
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LIBRIS-ID:oai:DiVA.org:uu-235190
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-235190URI
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https://doi.org/10.1093/eurheartj/ehu160DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Aims The optimal platelet inhibition strategy for ACS patients managed without revascularization is unknown. We aimed to evaluate efficacy and safety of ticagrelor vs. clopidogrel in the non-ST-elevation acute coronary syndrome (NSTE-ACS) subgroup of the PLATO trial, in the total cohort, and in the subgroups managed with and without revascularization within 10 days of randomization. Methods and results We performed a retrospective analysis of the primary endpoint of cardiovascular death/myocardial infarction/stroke. Among 18 624 PLATO patients, 11 080 (59%) were categorized as NSTE-ACS at randomization. During the initial 10 days, 74% had angiography, 46% PCI, and 5% CABG. In NSTE-ACS patients, the primary endpoint was reduced with ticagrelor vs. clopidogrel [10.0 vs. 12.3%; hazard ratio (HR) 0.83; 95% confidence interval (CI) = 0.74-0.93], as was myocardial infarction (6.6 vs. 7.7%; HR 0.86; 95% CI = 0.74-0.99), cardiovascular death (3.7 vs. 4.9%; HR 0.77; 95% CI = 0.64-0.93), and all-cause death (4.3 vs. 5.8%; HR 0.76; 95% CI = 0.64-0.90). Major bleeding rate was similar between treatment groups (13.4 vs. 12.6%; HR 1.07; 95% CI = 0.95-1.19), but ticagrelor was associated with an increase in non-CABG major bleeding (4.8 vs. 3.8%; HR 1.28; 95% CI = 1.05-1.56). Within the first 10 days, 5366 (48.4%) patients were managed without revascularization. Regardless of revascularization or not, ticagrelor consistently reduced the primary outcome (HR 0.86 vs. 0.85, interaction P = 0.93), and all-cause death (HR 0.75 vs. 0.73, interaction P = 0.89) with no significant increase in overall major bleeding. Conclusion In patients with NSTE-ACS, benefit of ticagrelor over clopidogrel in reducing ischaemic events and total mortality was consistent with the overall PLATO trial, independent of actually performed revascularization during the initial 10 days.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Varenhorst, ChristophUppsala universitet,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)chrva923
(författare)
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Cannon, Christopher P.
(författare)
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Harrington, Robert A.
(författare)
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Himmelmann, Anders
(författare)
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Maya, Juan
(författare)
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Husted, Steen
(författare)
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Steg, Philippe Gabriel
(författare)
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Cornel, Jan H.
(författare)
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Storey, Robert F.
(författare)
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Stevens, Susanna R.
(författare)
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Wallentin, LarsUppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi(Swepub:uu)larswall
(författare)
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James, Stefan K.Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)stjam367
(författare)
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Uppsala universitetKardiologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:European Heart Journal: Oxford University Press (OUP)35:31, s. 2083-20930195-668X1522-9645
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Maya, Juan
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Husted, Steen
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Steg, Philippe G ...
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Wallentin, Lars
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James, Stefan K.
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