Circulating antimüllerian hormone and steroid hormone levels remain high in pregnant women with polycystic ovary syndrome at term

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Piltonen, Terhi T.Univ Oulu, Oulu Univ Hosp, Dept Obstet & Gynecol, PEDEGO Res Unit,Med Res Ctr, Aapistie 5,Box 5000, Oulu 90014, Finland (author)

Objective: To investigate plasma antimullerian hormone (AMH) concentration and its relation to steroid hormone levels in pregnant women with polycystic ovary syndrome (PCOS) and controls at term.Design: Case-control study.Setting: University-affiliated hospital.Patient(s): A total of 74 pregnant women at term: 25 women with PCOS (aged 31.6 ± 3.9 years [mean ± standard deviation], body mass index 24.0 ± 3.9 kg/m2, mean gestational length 279 ± 9 days) and 49 controls (aged 31.7 ± 3.3 years, body mass index 24.0 ± 3.3 kg/m2, mean gestational length 281 ± 9 days).Intervention(s): None.Main Outcome Measure(s): Plasma AMH and steroid hormone levels.Result(s): Antimullerian hormone, T, and androstenedione levels were higher in women with PCOS at term compared with controls, whereas estrogen and P levels were similar. The differences were pronounced in women carrying a female fetus. Testosterone and AMH levels correlated positively in both groups, but E2 levels only in women with PCOS.Conclusion(s): Pregnant women with PCOS present with elevated AMH and androgen levels even at term, suggesting a hormonal imbalance during PCOS pregnancy. Differences were detected especially in pregnancies with a female fetus, raising the question of whether female pregnancies are more susceptible to AMH and steroid hormone actions.

Giacobini, PaoloINSERM, Jean Pierre Aubert Res Ctr, Lab Dev & Plast Neuroendocrine Brain, Lille, France;Univ Lille, Sch Med, Federat Hosp Univ, Lille, France (author)
Edvinsson, Åsa,1982-Uppsala universitet,Reproduktiv hälsa(Swepub:uu)asaed919 (author)
Hustad, SteinarUniv Bergen, Dept Clin Sci, Bergen, Norway;Univ Bergen, Core Facil Metabol, Bergen, Norway (author)
Lager, SusanneUppsala universitet,Obstetrisk och reproduktiv hälsoforskning(Swepub:uu)susla462 (author)
Morin-Papunen, LaureUniv Oulu, Oulu Univ Hosp, Dept Obstet & Gynecol, PEDEGO Res Unit,Med Res Ctr, Aapistie 5,Box 5000, Oulu 90014, Finland (author)
Tapanainen, Juha S.Univ Oulu, Oulu Univ Hosp, Dept Obstet & Gynecol, PEDEGO Res Unit,Med Res Ctr, Aapistie 5,Box 5000, Oulu 90014, Finland;Univ Helsinki, Dept Obstet & Gynecol, Helsinki, Finland;Helsinki Univ Cent Hosp, Helsinki, Finland (author)
Sundström-Poromaa, Inger,1964-Uppsala universitet,Reproduktiv hälsa(Swepub:uu)inspo702 (author)
Arffman, Riikka K.Univ Oulu, Oulu Univ Hosp, Dept Obstet & Gynecol, PEDEGO Res Unit,Med Res Ctr, Aapistie 5,Box 5000, Oulu 90014, Finland (author)
Univ Oulu, Oulu Univ Hosp, Dept Obstet & Gynecol, PEDEGO Res Unit,Med Res Ctr, Aapistie 5,Box 5000, Oulu 90014, FinlandINSERM, Jean Pierre Aubert Res Ctr, Lab Dev & Plast Neuroendocrine Brain, Lille, France;Univ Lille, Sch Med, Federat Hosp Univ, Lille, France (creator_code:org_t)

By the author/editor: Piltonen, Terhi ...; Giacobini, Paolo; Edvinsson, Åsa, ...; Hustad, Steinar; Lager, Susanne; Morin-Papunen, L ...; show more...; Tapanainen, Juha ...; Sundström-Poroma ...; Arffman, Riikka ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Obstetrics Gynae ...

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