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A pooled analysis o...
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Genkinger, Jeanine M.Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY 10032 USA.
(författare)
A pooled analysis of 14 cohort studies of anthropometric factors and pancreatic cancer risk
- Artikel/kapitelEngelska2011
Förlag, utgivningsår, omfång ...
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2011-03-04
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WILEY,2011
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-422083
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-422083URI
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https://doi.org/10.1002/ijc.25794DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:122990903URI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Epidemiologic studies of pancreatic cancer risk have reported null or nonsignificant positive associations for obesity, while associations for height have been null. Waist and hip circumference have been evaluated infrequently. A pooled analysis of 14 cohort studies on 846,340 individuals was conducted; 2,135 individuals were diagnosed with pancreatic cancer during follow-up. Study-specific relative risks (RRs) and 95% confidence intervals (CIs) were calculated by Cox proportional hazards models, and then pooled using a random effects model. Compared to individuals with a body mass index (BMI) at baseline between 21-22.9 kg/m(2), pancreatic cancer risk was 47% higher (95% CI:23-75%) among obese (BMI >= 30 kg/m(2)) individuals. A positive association was observed for BMI in early adulthood (pooled multivariate [MV]RR = 1.30, 95%CI = 1.09-1.56 comparing BMI >= 25 kg/m(2) to a BMI between 21 and 22.9 kg/m(2)). Compared to individuals who were not overweight in early adulthood (BMI < 25 kg/m(2)) and not obese at baseline (BMI < 30 kg/m(2)), pancreatic cancer risk was 54% higher (95%CI = 24-93%) for those who were overweight in early adulthood and obese at baseline. We observed a 40% higher risk among individuals who had gained BMI >= 10 kg/m(2) between BMI at baseline and younger ages compared to individuals whose BMI remained stable. Results were either similar or slightly stronger among never smokers. A positive association was observed between waist to hip ratio (WHR) and pancreatic cancer risk (pooled MVRR = 1.35 comparing the highest versus lowest quartile, 95%CI = 1.03-1.78). BMI and WHR were positively associated with pancreatic cancer risk. Maintaining normal body weight may offer a feasible approach to reducing morbidity and mortality from pancreatic cancer.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Spiegelman, DonnaHarvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA.
(författare)
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Anderson, Kristin E.Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA.;Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN USA.
(författare)
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Bernstein, LeslieCity Hope Natl Med Ctr, Div Canc Etiol, Duarte, CA 91010 USA.
(författare)
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van den Brandt, Piet A.Maastricht Univ, Dept Epidemiol, Sch Oncol & Dev Biol GROW, Maastricht, Netherlands.
(författare)
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Calle, Eugenia E.Amer Canc Soc, Atlanta, GA 30329 USA.
(författare)
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English, Dallas R.Canc Council Victoria, Canc Epidemiol Ctr, Melbourne, Vic, Australia.;Univ Melbourne, Melbourne, Vic, Australia.
(författare)
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Folsom, Aaron R.Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA.;Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN USA.
(författare)
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Freudenheim, Jo L.SUNY Buffalo, Dept Social & Prevent Med, Buffalo, NY 14260 USA.
(författare)
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Fuchs, Charles S.Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA USA.;Harvard Univ, Sch Med, Boston, MA USA.;Dana Farber Canc Inst, Div Med Oncol, Boston, MA 02115 USA.
(författare)
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Giles, Graham G.Canc Council Victoria, Canc Epidemiol Ctr, Melbourne, Vic, Australia.;Univ Melbourne, Melbourne, Vic, Australia.
(författare)
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Giovannucci, EdwardHarvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA USA.;Harvard Univ, Sch Med, Boston, MA USA.;Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.
(författare)
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Horn-Ross, Pamela L.No Calif Canc Ctr, Fremont, CA USA.
(författare)
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Larsson, Susanna C.Karolinska Institutet
(författare)
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Leitzmann, MichaelNCI, Nutr Epidemiol Branch, Div Canc Epidemiol & Genet, NIH,DHHS, Bethesda, MD 20892 USA.;Univ Regensburg, Inst Epidemiol & Prevent Med, Regensburg, Germany.
(författare)
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Mannisto, SatuNatl Inst Hlth & Welf, Dept Hlth Promot & Chron Dis Prevent, Helsinki, Finland.
(författare)
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Marshall, James R.SUNY Buffalo, Dept Social & Prevent Med, Buffalo, NY 14260 USA.
(författare)
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Miller, Anthony B.Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada.
(författare)
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Patel, Alpa V.Amer Canc Soc, Atlanta, GA 30329 USA.
(författare)
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Rohan, Thomas E.Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10467 USA.
(författare)
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Stolzenberg-Solomon, Rachael Z.NCI, Nutr Epidemiol Branch, Div Canc Epidemiol & Genet, NIH,DHHS, Bethesda, MD 20892 USA.
(författare)
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Verhage, Bas A. J.Maastricht Univ, Dept Epidemiol, Sch Oncol & Dev Biol GROW, Maastricht, Netherlands.
(författare)
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Virtamo, JarmoNatl Inst Hlth & Welf, Dept Hlth Promot & Chron Dis Prevent, Helsinki, Finland.
(författare)
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Willcox, Bradley J.Univ Hawaii, John A Burns Sch Med, Manoa, HI USA.;Okinawa Res Ctr Longev Sci, Okinawa, Japan.;Pacific Hlth Res Inst, Honolulu, HI USA.;Queens Med Ctr, Honolulu, HI USA.
(författare)
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Wolk, AlicjaKarolinska Institutet
(författare)
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Ziegler, Regina G.NCI, Epidemiol & Biostat Program, Div Canc Epidemiol & Genet, NIH,DHHS, Bethesda, MD 20892 USA.
(författare)
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Smith-Warner, Stephanie A.Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.
(författare)
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Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY 10032 USA.Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA.
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:International Journal of Cancer: WILEY129:7, s. 1708-17170020-71361097-0215
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Genkinger, Jeani ...
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Spiegelman, Donn ...
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Anderson, Kristi ...
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Bernstein, Lesli ...
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van den Brandt, ...
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Calle, Eugenia E ...
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visa fler...
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English, Dallas ...
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Folsom, Aaron R.
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Freudenheim, Jo ...
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Fuchs, Charles S ...
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Giles, Graham G.
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Giovannucci, Edw ...
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Horn-Ross, Pamel ...
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Larsson, Susanna ...
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Leitzmann, Micha ...
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Mannisto, Satu
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Marshall, James ...
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Miller, Anthony ...
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Patel, Alpa V.
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Rohan, Thomas E.
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Stolzenberg-Solo ...
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Verhage, Bas A. ...
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Virtamo, Jarmo
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Willcox, Bradley ...
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Wolk, Alicja
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Ziegler, Regina ...
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Smith-Warner, St ...
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