SwePub
Tyck till om SwePub Sök här!
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:DiVA.org:uu-469125"
 

Sökning: onr:"swepub:oai:DiVA.org:uu-469125" > [F-18]THK5317 imagi...

  • Chiotis, KonstantinosKarolinska Institutet (författare)

[F-18]THK5317 imaging as a tool for predicting prospective cognitive decline in Alzheimer's disease

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • 2020-07-03
  • Springer Nature,2021
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-469125
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-469125URI
  • https://doi.org/10.1038/s41380-020-0815-4DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:144111110URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Cross-sectional studies have indicated potential for positron emission tomography (PET) in imaging tau pathology in Alzheimer's disease (AD); however, its prognostic utility remains unproven. In a longitudinal, multi-modal, prognostic study of cognitive decline, 20 patients with a clinical biomarker-based diagnosis in the AD spectrum (mild cognitive impairment or dementia and a positive amyloid-beta PET scan) were recruited from the Cognitive Clinic at Karolinska University Hospital. The participants underwent baseline neuropsychological assessment, PET imaging with [F-18]THK5317, [C-11]PIB and [F-18]FDG, magnetic resonance imaging, and in a subgroup cerebrospinal fluid (CSF) sampling, with clinical follow-up after a median 48 months (interquartile range = 32:56). In total, 11 patients declined cognitively over time, while 9 remained cognitively stable. The accuracy of baseline [F-18]THK5317 binding in temporal areas was excellent at predicting future cognitive decline (area under the receiver operating curve 0.84-1.00) and the biomarker levels were strongly associated with the rate of cognitive decline (beta estimate -33.67 to -31.02,p < 0.05). The predictive accuracy of the other baseline biomarkers was poor (area under the receiver operating curve 0.58-0.77) and their levels were not associated with the rate of cognitive decline (beta estimate -4.64 to 15.78,p > 0.05). Baseline [F-18]THK5317 binding and CSF tau levels were more strongly associated with the MMSE score at follow-up than at baseline (p < 0.05). These findings support a temporal dissociation between tau deposition and cognitive impairment, and suggest that [F-18]THK5317 predicts future cognitive decline better than other biomarkers. The use of imaging markers for tau pathology could prove useful for clinical prognostic assessment and screening before inclusion in relevant clinical trials.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Savitcheva, IrinaKarolinska Univ Hosp, Med Radiat Phys & Nucl Med, Stockholm, Sweden. (författare)
  • Poulakis, KonstantinosKarolinska Institutet (författare)
  • Saint-Aubert, LaureKarolinska Inst, Dept Neurobiol Care Sci & Soc, Nordberg Translat Mol Imaging Lab, Div Clin Geriatr,Ctr Alzheimer Res, Stockholm, Sweden.;Univ Toulouse, Toulouse NeuroImaging Ctr, INSERM, UPS, Toulouse, France. (författare)
  • Wall, AndersUppsala universitet,Radiologi(Swepub:uu)andewall (författare)
  • Antoni, GunnarUppsala universitet,Preparativ läkemedelskemi(Swepub:uu)gunnarat (författare)
  • Nordberg, AgnetaKarolinska Institutet (författare)
  • Karolinska InstitutetKarolinska Univ Hosp, Med Radiat Phys & Nucl Med, Stockholm, Sweden. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Molecular Psychiatry: Springer Nature26:10, s. 5875-58871359-41841476-5578

Internetlänk

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy