Clinicians’ use of breast cancer risk assessment tools according to their perceived importance of breast cancer risk factors : an international survey

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The BOADICEA breast cancer (BC) risk assessment model and its associated Web Application v3 (BWA) tool are being extended to incorporate additional genetic and non-genetic BC risk factors. From an online survey through the BOADICEA website and UK, Dutch, French and Swedish national genetic societies, we explored the relationships between the usage frequencies of the BWA and six other common BC risk assessment tools and respondents’ perceived importance of BC risk factors. Respondents (N = 443) varied in age, country and clinical seniority but comprised mainly genetics health professionals (82%) and BWA users (93%). Oncology professionals perceived reproductive, hormonal (exogenous) and lifestyle BC risk factors as more important in BC risk assessment compared to genetics professionals (p values < 0.05 to 0.0001). BWA was used more frequently by respondents who gave high weight to breast tumour pathology and low weight to personal BC history as BC risk factors. BWA use was positively related to the weight given to hormonal BC risk factors. The importance attributed to lifestyle and BMI BC risk factors was not associated with the use of BWA or any of the other tools. Next version of the BWA encompassing additional BC risk factors will facilitate more comprehensive BC risk assessment in genetics and oncology practice.

Kop, Jean LucUniversity of Lorraine (author)
Antoniou, Antonis C.University of Cambridge (author)
Cunningham, Alex P.University of Cambridge (author)
de Pauw, AntoineCurie Institute, Paris (author)
Tischkowitz, MarcUniversity of Cambridge (author)
Ehrencrona, HansLund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)med-hen (author)
Schmidt, Marjanka K.Netherlands Cancer Institute (author)
Dolbeault, SylvieUniversity of Paris-Saclay,Curie Institute, Paris (author)
Rhiem, KerstinUniversity Hospital of Cologne (author)
Easton, Douglas F.University of Cambridge (author)
Devilee, PeterLeiden University Medical Centre (author)
Stoppa-Lyonnet, DominiqueCurie Institute, Paris (author)
Schmutlzer, RitaUniversity Hospital of Cologne (author)
Curie Institute, ParisParis Descartes University (creator_code:org_t)

In:Journal of Community Genetics: Springer Science and Business Media LLC10:1, s. 61-711868-310X1868-6001

By the author/editor: Brédart, Anne; Kop, Jean Luc; Antoniou, Antoni ...; Cunningham, Alex ...; de Pauw, Antoine; Tischkowitz, Mar ...; show more...; Ehrencrona, Hans; Schmidt, Marjank ...; Dolbeault, Sylvi ...; Rhiem, Kerstin; Easton, Douglas ...; Devilee, Peter; Stoppa-Lyonnet, ...; Schmutlzer, Rita; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

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