Search: onr:"swepub:oai:lup.lub.lu.se:3e5c03cd-7b22-4d63-b18b-b30b066e7fe9" >
New genetic loci li...
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Shungin, DmitryUmeå universitet,Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genetisk och molekylär epidemiologi,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Genetic and Molecular Epidemiology,Medicin,Institutionen för odontologi
(author)
New genetic loci link adipose and insulin biology to body fat distribution.
- Article/chapterEnglish2015
Publisher, publication year, extent ...
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2015-02-11
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Springer Science and Business Media LLC,2015
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:3e5c03cd-7b22-4d63-b18b-b30b066e7fe9
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https://lup.lub.lu.se/record/5144408URI
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https://doi.org/10.1038/nature14132DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-100950URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-244267URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:du-21323URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:130690385URI
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https://gup.ub.gu.se/publication/213559URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.
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Winkler, Thomas W
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Croteau-Chonka, Damien C
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Ferreira, Teresa
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Locke, Adam E
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Mägi, Reedik
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Strawbridge, Rona JKarolinska Institutet
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Pers, Tune H
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Fischer, Krista
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Justice, Anne E
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Workalemahu, Tsegaselassie
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Wu, Joseph M W
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Lind, LarsKarolinska Institutet,Uppsala universitet,Kardiovaskulär epidemiologi(Swepub:uu)larslind
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Heard-Costa, Nancy L
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Sundström, JohanUppsala universitet,Kardiovaskulär epidemiologi(Swepub:uu)johasund
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Drong, Alexander W
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Song, CiUppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)ciaso492
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Gustafsson, StefanUppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)stegu732
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Day, Felix R
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Esko, Tonu
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Fall, ToveUppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)tovfa878
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Kutalik, Zoltán
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Luan, Jian'an
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Vedantam, Sailaja
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Chen, Jin
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Hedman, Åsa KUppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)ashed124
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Mangino, Massimo
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Mateo Leach, Irene
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Stančáková, Alena
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Zhang, Weihua
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Ärnlöv, JohanHögskolan Dalarna,Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Medicinsk vetenskap,Uppasla universitet(Swepub:du)jan
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Arscott, Gillian M
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Bandinelli, Stefania
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Barrett, Amy
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Bellis, Claire
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Bennett, Amanda J
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Berne, ChristianUppsala universitet,Klinisk diabetologi och metabolism(Swepub:uu)chber255
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Blüher, Matthias
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Böhringer, Stefan
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Bonnet, Fabrice
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Doney, Alex S F
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Eklund, Niina
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Erdos, Michael R
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Estrada, KarolKarolinska Institutet
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Eury, Elodie
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Friedrich, Nele
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Garcia, Melissa E
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Giedraitis, VilmantasUppsala universitet,Geriatrik(Swepub:uu)vigie517
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Gigante, BrunaKarolinska Institutet
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Go, Alan S
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Golay, Alain
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Grallert, Harald
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Grammer, Tanja B
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Gräßler, Jürgen
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Grewal, Jagvir
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Groves, Christopher J
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Haller, Toomas
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Hallmans, GöranUmeå universitet,Näringsforskning,Enheten för biobanksforskning(Swepub:umu)goha0001
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Hartman, Catharina A
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Hassinen, Maija
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Hayward, Caroline
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Heikkilä, Kauko
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Kinnunen, Leena
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Kooner, Ishminder K
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Kratzer, Wolfgang
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Lamina, Claudia
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Leander, KarinKarolinska Institutet
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Lee, Nanette R
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Lichtner, Peter
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Lind, Lars
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Lindström, Jaana
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Lobbens, Stéphane
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Lorentzon, Mattias,1970Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xlomat
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Mach, François
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Magnusson, Patrik K EKarolinska Institutet
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Mahajan, Anubha
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McArdle, Wendy L
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Menni, Cristina
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Merger, Sigrun
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Mihailov, Evelin
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Milani, Lili
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Mills, Rebecca
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Mühleisen, Thomas W
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Müller-Nurasyid, Martina
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Nagaraja, Ramaiah
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Nalls, Michael A
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Narisu, Narisu
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Glorioso, Nicola
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Nolte, Ilja M
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Olden, Matthias
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Rayner, Nigel W
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Renström, FridaLund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups(Swepub:lu)med-frm
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Ried, Janina S
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Robertson, Neil R
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Rose, Lynda M
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Sanna, Serena
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Scharnagl, Hubert
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Scholtens, Salome
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Sennblad, BengtKarolinska Institutet
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Seufferlein, Thomas
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Sitlani, Colleen M
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Vernon Smith, Albert
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Stirrups, Kathleen
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Stringham, Heather M
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Sundström, Johan
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Swertz, Morris A
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Swift, Amy J
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Syvänen, Ann-ChristineUppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab(Swepub:uu)anncsyva
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Tayo, Bamidele O
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Thorand, Barbara
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Franco-Cereceda, AndersKarolinska Institutet
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Gharavi, Ali G
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Hedman, Åsa K
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Hivert, Marie-France
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Huang, Jinyan
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Olsson, ChristianKarolinska Institutet
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Reinmaa, Eva
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de Faire, UlfKarolinska Institutet
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de Geus, Eco J C
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Dörr, Marcus
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Erbel, Raimund
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Eriksson, Johan G
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Farrall, Martin
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Ferrannini, Ele
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Ferrières, Jean
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Forrester, Terrence
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Franco, Oscar H
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Gansevoort, Ron T
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Gieger, Christian
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Gudnason, Vilmundur
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Haiman, Christopher A
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Harris, Tamara B
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Hattersley, Andrew T
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Heliövaara, Markku
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Hicks, Andrew A
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Hingorani, Aroon D
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Hoffmann, Wolfgang
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Hofman, Albert
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Homuth, Georg
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Humphries, Steve E
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Hyppönen, Elina
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Illig, Thomas
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Jarvelin, Marjo-Riitta
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Johansen, Berit
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Jousilahti, Pekka
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Jula, Antti M
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Kaprio, Jaakko
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Kee, Frank
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Keinanen-Kiukaanniemi, Sirkka M
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Kooner, Jaspal S
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Kooperberg, Charles
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Kovacs, Peter
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Kraja, Aldi T
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Kumari, Meena
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Kuulasmaa, Kari
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Kuusisto, Johanna
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Lakka, Timo A
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Langenberg, Claudia
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Le Marchand, Loic
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Lehtimäki, Terho
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Lyssenko, ValeriyaLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-vly
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Männistö, Satu
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Ohlsson, Claes,1965Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xohlcl
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Oldehinkel, Albertine J
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Hamsten, AndersKarolinska Institutet
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Hui, Jennie
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Jöckel, Karl-Heinz
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Perola, Markus
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Pérusse, Louis
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Peters, Ulrike
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Power, Chris
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Quertermous, Thomas
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Rauramaa, Rainer
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Rivadeneira, Fernando
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Saaristo, Timo E
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Saleheen, Danish
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Sinisalo, Juha
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Slagboom, P Eline
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Snieder, Harold
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Spector, Tim D
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Thorsteinsdottir, Unnur
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Stumvoll, Michael
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Tuomilehto, Jaakko
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Uitterlinden, André G
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Uusitupa, Matti
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van der Harst, Pim
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Veronesi, Giovanni
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Walker, Mark
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Wareham, Nicholas J
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Watkins, Hugh
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Wichmann, H-Erich
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Abecasis, Goncalo R
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Assimes, Themistocles L
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Berndt, Sonja I
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Boehnke, Michael
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Borecki, Ingrid B
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Deloukas, Panos
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Franke, Lude
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Frayling, Timothy M
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Groop, LeifLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-lgr
(author)
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Hunter, David J
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Kaplan, Robert C
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O'Connell, Jeffrey R
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Qi, Lu
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Schlessinger, David
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Strachan, David P
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Stefansson, Kari
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van Duijn, Cornelia M
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Willer, Cristen J
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Visscher, Peter M
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Yang, Jian
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Hirschhorn, Joel N
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Zillikens, M Carola
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McCarthy, Mark I
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Speliotes, Elizabeth K
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North, Kari E
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Fox, Caroline S
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Barroso, Inês
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Franks, Paul W
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Ingelsson, ErikUppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)ering425
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Heid, Iris M
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Loos, Ruth J F
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Cupples, L Adrienne
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Morris, Andrew P
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Lindgren, Cecilia M
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Mohlke, Karen L
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Graessler, Juergen
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Uusitupa, Math
(author)
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Genomik, diabetes och endokrinologiForskargrupper vid Lunds universitet
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Shungin, Dmitry
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Winkler, Thomas ...
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Croteau-Chonka, ...
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Ferreira, Teresa
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Locke, Adam E
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Mägi, Reedik
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Strawbridge, Ron ...
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Pers, Tune H
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Fischer, Krista
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Justice, Anne E
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Wu, Joseph M W
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Lind, Lars
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Heard-Costa, Nan ...
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Sundström, Johan
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Drong, Alexander ...
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Song, Ci
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Gustafsson, Stef ...
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Day, Felix R
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Esko, Tonu
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Fall, Tove
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Kutalik, Zoltán
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Luan, Jian'an
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Randall, Joshua ...
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Wood, Andrew R
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Chen, Jin
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Fehrmann, Rudolf
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Karjalainen, Juh ...
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Kahali, Bratati
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Liu, Ching-Ti
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Schmidt, Ellen M
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Absher, Devin
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Anderson, Denise
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Bragg-Gresham, J ...
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Buyske, Steven
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Demirkan, Ayse
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Ehret, Georg B
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Feitosa, Mary F
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Goel, Anuj
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Jackson, Anne U
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Johnson, Toby
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Kleber, Marcus E
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Palmer, Cameron ...
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Ju Sung, Yun
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Teumer, Alexande ...
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Yengo, Loïc
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Zhang, Weihua
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Albrecht, Eva
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Ärnlöv, Johan
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Arscott, Gillian ...
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Bandinelli, Stef ...
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Barrett, Amy
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Bellis, Claire
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Berne, Christian
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Blüher, Matthias
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Böhringer, Stefa ...
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Bonnet, Fabrice
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Bruinenberg, Mar ...
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Carba, Delia B
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Caspersen, Ida H
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Clarke, Robert
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Daw, E Warwick
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Deelen, Joris
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Deelman, Ewa
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Delgado, Graciel ...
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Doney, Alex S F
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Eklund, Niina
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Erdos, Michael R
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Estrada, Karol
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Eury, Elodie
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Friedrich, Nele
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Garcia, Melissa ...
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Giedraitis, Vilm ...
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Gigante, Bruna
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Go, Alan S
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Golay, Alain
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Grallert, Harald
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Grammer, Tanja B
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Gräßler, Jürgen
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Grewal, Jagvir
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Groves, Christop ...
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Haller, Toomas
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Hartman, Cathari ...
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Hassinen, Maija
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Hayward, Carolin ...
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Heikkilä, Kauko
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Herzig, Karl-Hei ...
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Helmer, Quinta
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Hillege, Hans L
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Holmen, Oddgeir
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Hunt, Steven C
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Isaacs, Aaron
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Ittermann, Till
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James, Alan L
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Johansson, Ingeg ...
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Juliusdottir, Th ...
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Kalafati, Ioanna ...
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Kinnunen, Leena
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Koenig, Wolfgang
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Kooner, Ishminde ...
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Kratzer, Wolfgan ...
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Lamina, Claudia
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Leander, Karin
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Lee, Nanette R
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Lichtner, Peter
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Lindström, Jaana
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Lobbens, Stéphan ...
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Lorentzon, Matti ...
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Mach, François
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Magnusson, Patri ...
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Mahajan, Anubha
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McArdle, Wendy L
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Menni, Cristina
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Merger, Sigrun
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Mihailov, Evelin
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Milani, Lili
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Mills, Rebecca
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Moayyeri, Alirez ...
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Monda, Keri L
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Mooijaart, Simon ...
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Mühleisen, Thoma ...
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Mulas, Antonella
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Müller, Gabriele
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Müller-Nurasyid, ...
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Nagaraja, Ramaia ...
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Nalls, Michael A
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Narisu, Narisu
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Glorioso, Nicola
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Nolte, Ilja M
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Olden, Matthias
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Rayner, Nigel W
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Renström, Frida
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Ried, Janina S
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Robertson, Neil ...
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Rose, Lynda M
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Sanna, Serena
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Scharnagl, Huber ...
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Scholtens, Salom ...
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Sennblad, Bengt
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Stringham, Heath ...
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Swift, Amy J
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Tayo, Bamidele O
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van Oort, Floor ...
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Verweij, Niek
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Vonk, Judith M
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Waite, Lindsay L
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Wennauer, Roman
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Wojczynski, Mary ...
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Wong, Andrew
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Zhang, Qunyuan
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Hua Zhao, Jing
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Brennan, Eoin P
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Choi, Murim
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Eriksson, Per
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Folkersen, Lasse
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Franco-Cereceda, ...
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Gharavi, Ali G
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Hivert, Marie-Fr ...
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Huang, Jinyan
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Kanoni, Stavroul ...
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Karpe, Fredrik
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Keildson, Sarah
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Liang, Liming
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Lifton, Richard ...
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Ma, Baoshan
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McKnight, Amy J
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McPherson, Ruth
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Metspalu, Andres
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Min, Josine L
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Moffatt, Miriam ...
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Montgomery, Gran ...
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Murabito, Joanne ...
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Nicholson, Georg ...
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Nyholt, Dale R
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Olsson, Christia ...
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Perry, John R B
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Reinmaa, Eva
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Salem, Rany M
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Sandholm, Niina
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Schadt, Eric E
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Scott, Robert A
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Stolk, Lisette
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Vallejo, Edgar E
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Westra, Harm-Jan
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Zondervan, Krina ...
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Amouyel, Philipp ...
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Arveiler, Domini ...
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Bakker, Stephan ...
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Beilby, John
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Bergman, Richard ...
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Blangero, John
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Brown, Morris J
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Burnier, Michel
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Campbell, Harry
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Chakravarti, Ara ...
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Chines, Peter S
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Claudi-Boehm, Si ...
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Collins, Francis ...
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Crawford, Dana C
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Danesh, John
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de Faire, Ulf
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de Geus, Eco J C
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Dörr, Marcus
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Erbel, Raimund
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Eriksson, Johan ...
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Farrall, Martin
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Ferrannini, Ele
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Ferrières, Jean
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Forouhi, Nita G
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Forrester, Terre ...
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Franco, Oscar H
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Gansevoort, Ron ...
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Gieger, Christia ...
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Gudnason, Vilmun ...
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Haiman, Christop ...
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Harris, Tamara B
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Hattersley, Andr ...
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Heliövaara, Mark ...
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Hicks, Andrew A
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Hoffmann, Wolfga ...
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Hofman, Albert
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Homuth, Georg
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Humphries, Steve ...
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Hyppönen, Elina
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Illig, Thomas
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Johansen, Berit
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Jousilahti, Pekk ...
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Jula, Antti M
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Kooperberg, Char ...
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Kovacs, Peter
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Kraja, Aldi T
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Kumari, Meena
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Kuulasmaa, Kari
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Kuusisto, Johann ...
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Lakka, Timo A
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Langenberg, Clau ...
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Le Marchand, Loi ...
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Lehtimäki, Terho
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Lyssenko, Valeri ...
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Männistö, Satu
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Marette, André
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Matise, Tara C
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McKenzie, Colin ...
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McKnight, Barbar ...
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Musk, Arthur W
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Möhlenkamp, Stef ...
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Morris, Andrew D
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Nelis, Mari
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Ohlsson, Claes, ...
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Oldehinkel, Albe ...
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Ong, Ken K
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Palmer, Lyle J
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Penninx, Brenda ...
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Peters, Annette
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Raitakari, Olli ...
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Rankinen, Tuomo
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Rao, D C
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Rice, Treva K
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Ridker, Paul M
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Ritchie, Marylyn ...
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Rudan, Igor
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Salomaa, Veikko
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Samani, Nilesh J
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Saramies, Jouko
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Sarzynski, Mark ...
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Stolk, Ronald P
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Strauch, Konstan ...
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Tönjes, Anke
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Tremblay, Angelo
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Völker, Uwe
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Vollenweider, Pe ...
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Wilson, James F
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Adair, Linda S
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Bochud, Murielle
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Boehm, Bernhard ...
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Bornstein, Stefa ...
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Bouchard, Claude
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Cauchi, Stéphane
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Caulfield, Mark ...
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Chambers, John C
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Chasman, Daniel ...
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Cooper, Richard ...
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Dedoussis, Georg ...
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Ferrucci, Luigi
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Froguel, Philipp ...
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Grabe, Hans-Jörg ...
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Hamsten, Anders
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Hui, Jennie
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Jöckel, Karl-Hei ...
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Kivimaki, Mika
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Kuh, Diana
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Laakso, Markku
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Liu, Yongmei
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März, Winfried
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Munroe, Patricia ...
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Njølstad, Inger
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Oostra, Ben A
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Pedersen, Nancy ...
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Perola, Markus
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Pérusse, Louis
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Peters, Ulrike
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Power, Chris
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Quertermous, Tho ...
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Rauramaa, Rainer
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Rivadeneira, Fer ...
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Saaristo, Timo E
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Saleheen, Danish
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Sinisalo, Juha
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Slagboom, P Elin ...
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Snieder, Harold
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Walker, Mark
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Watkins, Hugh
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Abecasis, Goncal ...
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Assimes, Themist ...
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Berndt, Sonja I
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Boehnke, Michael
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Borecki, Ingrid ...
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Deloukas, Panos
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Franke, Lude
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Frayling, Timoth ...
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Groop, Leif
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Hunter, David J
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Kaplan, Robert C
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O'Connell, Jeffr ...
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Qi, Lu
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Schlessinger, Da ...
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Strachan, David ...
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Stefansson, Kari
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van Duijn, Corne ...
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Willer, Cristen ...
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Visscher, Peter ...
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Yang, Jian
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Hirschhorn, Joel ...
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Zillikens, M Car ...
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McCarthy, Mark I
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Speliotes, Eliza ...
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North, Kari E
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Fox, Caroline S
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Barroso, Inês
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Franks, Paul W
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Ingelsson, Erik
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Heid, Iris M
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Loos, Ruth J F
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Cupples, L Adrie ...
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Morris, Andrew P
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Lindgren, Cecili ...
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Mohlke, Karen L
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Uusitupa, Math
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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- Articles in the publication
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Nature
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Lund University
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Umeå University
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Uppsala University
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Högskolan Dalarna
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Karolinska Institutet
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University of Gothenburg