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Population-Based St...
Population-Based Study of the Risk of Second Primary Contralateral Breast Cancer Associated With Carrying a Mutation in BRCA1 or BRCA2.
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Malone, Kathleen E (author)
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Begg, Colin B (author)
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Haile, Robert W (author)
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- Borg, Åke (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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Concannon, Patrick (author)
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- Tellhed, Lina (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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Xue, Shanyan (author)
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Teraoka, Sharon (author)
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Bernstein, Leslie (author)
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Capanu, Marinela (author)
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Reiner, Anne S (author)
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Riedel, Elyn R (author)
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Thomas, Duncan C (author)
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Mellemkjær, Lene (author)
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Lynch, Charles F (author)
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Boice, John D (author)
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Anton-Culver, Hoda (author)
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Bernstein, Jonine L (author)
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(creator_code:org_t)
- 2010
- 2010
- English.
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In: Journal of Clinical Oncology. - 1527-7755. ; 28, s. 2404-2410
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
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- PURPOSE: Women with breast cancer diagnosed early in life comprise a substantial portion of those tested for BRCA1/BRCA2 mutations; however, little information is available on the subsequent risks of contralateral breast cancer in mutation carriers. This study assessed the risk of subsequent contralateral breast cancer associated with carrying a BRCA1 or BRCA2 mutation. PATIENTS AND METHODS: In this nested case-control study, patients with contralateral breast cancer diagnosed 1 year or more after a first primary breast cancer (n = 705) and controls with unilateral breast cancer (n = 1,398) were ascertained from an underlying population-based cohort of 52,536 women diagnosed with a first invasive breast cancer before age 55 years. Interviews and medical record reviews were used to collect risk factor and treatment histories. All women were tested for BRCA1/BRCA2 mutations. Relative (rate ratios) and absolute (5- and 10-year cumulative) risks of developing contralateral breast cancer following a first invasive breast cancer were computed. RESULTS: Compared with noncarriers, BRCA1 and BRCA2 mutation carriers had 4.5-fold (95% CI, 2.8- to 7.1-fold) and 3.4-fold (95% CI, 2.0- to 5.8-fold) increased risks of contralateral breast cancer, respectively. The relative risk of contralateral breast cancer for BRCA1 mutation carriers increased as age of first diagnosis decreased. Age-specific cumulative risks are provided for clinical guidance. CONCLUSION: The risks of subsequent contralateral breast cancer are substantial for women who carry a BRCA1/BRCA2 mutation. These findings have important clinical relevance regarding the assessment of BRCA1/BRCA2 status in patients with breast cancer and the counseling and clinical management of patients found to carry a mutation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- By the author/editor
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Malone, Kathleen ...
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Begg, Colin B
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Haile, Robert W
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Borg, Åke
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Concannon, Patri ...
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Tellhed, Lina
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show more...
-
Xue, Shanyan
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Teraoka, Sharon
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Bernstein, Lesli ...
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Capanu, Marinela
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Reiner, Anne S
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Riedel, Elyn R
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Thomas, Duncan C
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Mellemkjær, Lene
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Lynch, Charles F
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Boice, John D
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Anton-Culver, Ho ...
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Bernstein, Jonin ...
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show less...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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Journal of Clini ...
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Lund University