Landscape of somatic mutations in 560 breast cancer whole-genome sequences

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Tyck till om SwePub Sök här!

Search: onr:"swepub:oai:lup.lub.lu.se:78b7cd41-aebe-4756-b732-c07ef1455952" > Landscape of somati...

1 of 1
Previous record
Next record
To hitlist

Details
MARC

Nik-Zainal, SerenaWellcome Trust Sanger Institute (author)

Landscape of somatic mutations in 560 breast cancer whole-genome sequences

Article/chapterEnglish2016

Publisher, publication year, extent ...

2016-05-02
Springer Science and Business Media LLC,2016
8 s.

Numbers

LIBRIS-ID:oai:lup.lub.lu.se:78b7cd41-aebe-4756-b732-c07ef1455952
https://lup.lub.lu.se/record/78b7cd41-aebe-4756-b732-c07ef1455952URI
https://doi.org/10.1038/nature17676DOI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:art swepub-publicationtype
Subject category:ref swepub-contenttype

Notes

We analysed whole-genome sequences of 560 breast cancers to advance understanding of the driver mutations conferring clonal advantage and the mutational processes generating somatic mutations. We found that 93 protein-coding cancer genes carried probable driver mutations. Some non-coding regions exhibited high mutation frequencies, but most have distinctive structural features probably causing elevated mutation rates and do not contain driver mutations. Mutational signature analysis was extended to genome rearrangements and revealed twelve base substitution and six rearrangement signatures. Three rearrangement signatures, characterized by tandem duplications or deletions, appear associated with defective homologous-recombination-based DNA repair: one with deficient BRCA1 function, another with deficient BRCA1 or BRCA2 function, the cause of the third is unknown. This analysis of all classes of somatic mutation across exons, introns and intergenic regions highlights the repertoire of cancer genes and mutational processes operating, and progresses towards a comprehensive account of the somatic genetic basis of breast cancer.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Medicinsk genetik hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Medical Genetics hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Cell- och molekylärbiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Cell and Molecular Biology hsv//eng
Breast Neoplasms
Cohort Studies
DNA Mutational Analysis
DNA Replication
DNA, Neoplasm
Female
Genes, BRCA1
Genes, BRCA2
Genome, Human
Genomics
Humans
Male
Mutagenesis
Mutation
Mutation Rate
Oncogenes
Recombinational DNA Repair

Added entries (persons, corporate bodies, meetings, titles ...)

Davies, HelenWellcome Trust Sanger Institute (author)
Staaf, JohanLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)onk-jst (author)
Ramakrishna, ManasaWellcome Trust Sanger Institute (author)
Glodzik, DominikWellcome Trust Sanger Institute (author)
Zou, XueqingWellcome Trust Sanger Institute (author)
Martincorena, InigoWellcome Trust Sanger Institute (author)
Alexandrov, Ludmil BWellcome Trust Sanger Institute (author)
Martin, SanchaWellcome Trust Sanger Institute (author)
Wedge, David CWellcome Trust Sanger Institute (author)
Van Loo, Peter (author)
Ju, Young Seok (author)
Smid, Marcel (author)
Brinkman, Arie B (author)
Morganella, Sandro (author)
Aure, Miriam R (author)
Lingjærde, Ole Christian (author)
Langerød, Anita (author)
Ringnér, MarkusLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)thep-mri (author)
Ahn, Sung-Min (author)
Boyault, Sandrine (author)
Brock, Jane E (author)
Broeks, Annegien (author)
Butler, Adam (author)
Desmedt, Christine (author)
Dirix, Luc (author)
Dronov, Serge (author)
Fatima, Aquila (author)
Foekens, John A (author)
Gerstung, Moritz (author)
Hooijer, Gerrit K J (author)
Jang, Se Jin (author)
Jones, David R (author)
Kim, Hyung-Yong (author)
King, Tari A (author)
Krishnamurthy, Savitri (author)
Lee, Hee Jin (author)
Lee, Jeong-Yeon (author)
Li, Yilong (author)
McLaren, Stuart (author)
Menzies, Andrew (author)
Mustonen, Ville (author)
O'Meara, Sarah (author)
Pauporté, Iris (author)
Pivot, Xavier (author)
Purdie, Colin A (author)
Raine, Keiran (author)
Ramakrishnan, Kamna (author)
Rodríguez-González, F Germán (author)
Romieu, Gilles (author)
Sieuwerts, Anieta M (author)
Simpson, Peter T (author)
Shepherd, Rebecca (author)
Stebbings, Lucy (author)
Stefansson, Olafur A (author)
Teague, Jon (author)
Tommasi, Stefania (author)
Treilleux, Isabelle (author)
Van den Eynden, Gert G (author)
Vermeulen, Peter (author)
Vincent-Salomon, Anne (author)
Yates, Lucy (author)
Caldas, Carlos (author)
van't Veer, Laura (author)
Tutt, Andrew (author)
Knappskog, Stian (author)
Tan, Benita Kiat Tee (author)
Jonkers, Jos (author)
Borg, ÅkeLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Familjär bröstcancer,Forskargrupper vid Lunds universitet,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Familial Breast Cancer,Lund University Research Groups(Swepub:lu)onk-abo (author)
Ueno, Naoto T (author)
Sotiriou, Christos (author)
Viari, Alain (author)
Futreal, P Andrew (author)
Campbell, Peter J (author)
Span, Paul N (author)
Van Laere, Steven (author)
Lakhani, Sunil R (author)
Eyfjord, Jorunn E (author)
Thompson, Alastair M (author)
Birney, Ewan (author)
Stunnenberg, Hendrik G (author)
van de Vijver, Marc J (author)
Martens, John W M (author)
Børresen-Dale, Anne-Lise (author)
Richardson, Andrea L (author)
Kong, Gu (author)
Thomas, Gilles (author)
Stratton, Michael R (author)
Wellcome Trust Sanger InstituteBröstcancer-genetik (creator_code:org_t)

Related titles

In:Nature: Springer Science and Business Media LLC534:7605, s. 47-540028-08361476-4687

Internet link

Find in a library

Nature (Search for host publication in LIBRIS)

To the university's database

1 of 1
Previous record
Next record
To hitlist

Find more in SwePub

By the author/editor: Nik-Zainal, Sere ...; Davies, Helen; Staaf, Johan; Ramakrishna, Man ...; Glodzik, Dominik; Zou, Xueqing; show more...; Martincorena, In ...; Alexandrov, Ludm ...; Martin, Sancha; Wedge, David C; Van Loo, Peter; Ju, Young Seok; Smid, Marcel; Brinkman, Arie B; Morganella, Sand ...; Aure, Miriam R; Lingjærde, Ole C ...; Langerød, Anita; Ringnér, Markus; Ahn, Sung-Min; Boyault, Sandrin ...; Brock, Jane E; Broeks, Annegien; Butler, Adam; Desmedt, Christi ...; Dirix, Luc; Dronov, Serge; Fatima, Aquila; Foekens, John A; Gerstung, Moritz; Hooijer, Gerrit ...; Jang, Se Jin; Jones, David R; Kim, Hyung-Yong; King, Tari A; Krishnamurthy, S ...; Lee, Hee Jin; Lee, Jeong-Yeon; Li, Yilong; McLaren, Stuart; Menzies, Andrew; Mustonen, Ville; O'Meara, Sarah; Pauporté, Iris; Pivot, Xavier; Purdie, Colin A; Raine, Keiran; Ramakrishnan, Ka ...; Rodríguez-Gonzál ...; Romieu, Gilles; Sieuwerts, Aniet ...; Simpson, Peter T; Shepherd, Rebecc ...; Stebbings, Lucy; Stefansson, Olaf ...; Teague, Jon; Tommasi, Stefani ...; Treilleux, Isabe ...; Van den Eynden, ...; Vermeulen, Peter; Vincent-Salomon, ...; Yates, Lucy; Caldas, Carlos; van't Veer, Laur ...; Tutt, Andrew; Knappskog, Stian; Tan, Benita Kiat ...; Jonkers, Jos; Borg, Åke; Ueno, Naoto T; Sotiriou, Christ ...; Viari, Alain; Futreal, P Andre ...; Campbell, Peter ...; Span, Paul N; Van Laere, Steve ...; Lakhani, Sunil R; Eyfjord, Jorunn ...; Thompson, Alasta ...; Birney, Ewan; Stunnenberg, Hen ...; van de Vijver, M ...; Martens, John W ...; Børresen-Dale, A ...; Richardson, Andr ...; Kong, Gu; Thomas, Gilles; Stratton, Michae ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Medical Genetics

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Cell and Molecul ...

Articles in the publication: Nature

By the university: Lund University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se