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Fractional flow res...
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Zimmermann, Frederik M.Catharina Hospital
(författare)
Fractional flow reserve-guided percutaneous coronary intervention vs. medical therapy for patients with stable coronary lesions : meta-analysis of individual patient data
- Artikel/kapitelEngelska2019
Förlag, utgivningsår, omfång ...
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2018-12-28
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Oxford University Press (OUP),2019
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7 s.
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:84e1a44a-fcc6-4f0e-a05d-6d30325f23e1
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https://lup.lub.lu.se/record/84e1a44a-fcc6-4f0e-a05d-6d30325f23e1URI
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https://doi.org/10.1093/eurheartj/ehy812DOI
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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Aims: To assess the effect of fractional flow reserve (FFR)-guided percutaneous coronary intervention (PCI) with contemporary drug-eluting stents on the composite of cardiac death or myocardial infarction (MI) vs. medical therapy in patients with stable coronary lesions. Methods and results: We performed a systematic review and meta-analysis of individual patient data (IPD) of the three available randomized trials of contemporary FFR-guided PCI vs. medical therapy for patients with stable coronary lesions: FAME 2 (NCT01132495), DANAMI-3-PRIMULTI (NCT01960933), and Compare-Acute (NCT01399736). FAME 2 enrolled patients with stable coronary artery disease (CAD), while the other two focused on non-culprit lesions in stabilized patients after acute coronary syndrome. A total of 2400 subjects were recruited from 54 sites world-wide with 1056 randomly assigned to FFR-guided PCI and 1344 to medical therapy. The pre-specified primary outcome was a composite of cardiac death or MI. We included data from extended follow-ups for FAME 2 (up to 5.5 years follow-up) and DANAMI-3-PRIMULTI (up to 4.7 years follow-up). After a median follow-up of 35 months (interquartile range 12-60 months), a reduction in the composite of cardiac death or MI was observed with FFR-guided PCI as compared with medical therapy (hazard ratio 0.72, 95% confidence interval 0.54-0.96; P = 0.02). The difference between groups was driven by MI. Conclusion: In this IPD meta-analysis of the three available randomized controlled trials to date, FFR-guided PCI resulted in a reduction of the composite of cardiac death or MI compared with medical therapy, which was driven by a decreased risk of MI.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Omerovic, ElmirSahlgrenska University Hospital
(författare)
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Fournier, StephaneHartcentrum OLV Aalst,Lausanne University Hospital
(författare)
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Kelbæk, HenningZealand University Hospital
(författare)
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Johnson, Nils P.University of Texas Health Science Center at Houston,Memorial Hermann-Texas Medical Center
(författare)
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Rothenbühler, MartinaUniversity of Bern
(författare)
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Xaplanteris, PanagiotisHartcentrum OLV Aalst
(författare)
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Abdel-Wahab, MohamedSegeberger Kliniken
(författare)
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Barbato, EmanueleUniversity of Naples Federico II,Hartcentrum OLV Aalst
(författare)
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Høfsten, Dan EikCopenhagen University Hospital,University of Copenhagen
(författare)
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Tonino, Pim A.L.Catharina Hospital
(författare)
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Boxma-de Klerk, Bianca M.Maasstad Ziekenhuis
(författare)
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Fearon, William F.Stanford University
(författare)
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Køber, LarsCopenhagen University Hospital,University of Copenhagen
(författare)
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Smits, Pieter C.Maasstad Ziekenhuis
(författare)
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De Bruyne, BernardLausanne University Hospital,Hartcentrum OLV Aalst
(författare)
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Pijls, Nico H.J.Eindhoven University of Technology,Catharina Hospital
(författare)
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Jüni, PeterUniversity of Toronto,Saint Michael's Hospital
(författare)
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Engstrøm, ThomasLund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Copenhagen University Hospital,University of Copenhagen(Swepub:lu)th4331en
(författare)
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Catharina HospitalSahlgrenska University Hospital
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:European Heart Journal: Oxford University Press (OUP)40:2, s. 180-1861522-96450195-668X
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Zimmermann, Fred ...
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Omerovic, Elmir
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Fournier, Stepha ...
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Kelbæk, Henning
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Johnson, Nils P.
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Rothenbühler, Ma ...
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visa fler...
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Xaplanteris, Pan ...
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Abdel-Wahab, Moh ...
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Barbato, Emanuel ...
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Høfsten, Dan Eik
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Tonino, Pim A.L.
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Boxma-de Klerk, ...
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Fearon, William ...
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Køber, Lars
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Smits, Pieter C.
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De Bruyne, Berna ...
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Pijls, Nico H.J.
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Jüni, Peter
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Engstrøm, Thomas
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European Heart J ...
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