From iPS Cells to Rodents and Nonhuman Primates : Filling Gaps in Modeling Parkinson's Disease

Outeiro, Tiago F.Max Planck Institute of Experimental Medicine,University of Newcastle upon Tyne,University Medical Center Göttingen (author)

Parkinson's disease (PD) is primarily known as a movement disorder because of typical clinical manifestations associated with the loss of dopaminergic neurons in the substantia nigra. However, it is now widely recognized that PD is a much more complex condition, with multiple and severe nonmotor features implicating additional brain areas and organs in the disease process. Pathologically, typical forms of PD are characterized by the accumulation of α-synuclein-rich protein inclusions known as Lewy bodies and Lewy neurites, although other types of protein inclusions are also often present in the brain. Familial forms of PD have provided a wealth of information about molecular pathways leading to neurodegeneration, but only to add to the complexity of the problem and uncover new knowledge gaps. Therefore, modeling PD in the laboratory has become increasingly challenging. Here, we discuss knowledge gaps and challenges in the use of laboratory models for the study of a disease that is clinically heterogeneous and multifactorial. We propose that the combined use of patient-derived cells and animal models, along with current technological tools, will not only expand our molecular and pathophysiological understanding of PD, but also assist in the identification of therapeutic strategies targeting relevant pathogenic pathways.

Heutink, PeterGerman Center for Neurodegenerative Diseases (DZNE), Bonn (author)
Bezard, ErwanUniversity of Bordeaux (author)
Cenci, Angela M.Lund University,Lunds universitet,Basala gangliernas patofysiologi,Forskargrupper vid Lunds universitet,Basal Ganglia Pathophysiology,Lund University Research Groups(Swepub:lu)mphy-ace (author)
Max Planck Institute of Experimental MedicineUniversity of Newcastle upon Tyne (creator_code:org_t)

By the author/editor: Outeiro, Tiago F ...; Heutink, Peter; Bezard, Erwan; Cenci, Angela M.

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.