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Sökning: onr:"swepub:oai:lup.lub.lu.se:fce6f9fa-bc98-486b-bd03-07775837df08" > Association of chan...

  • de las Heras Gala, ToniaHelmholtz Zentrum München,German Center for Diabetes Research (författare)

Association of changes in inflammation with variation in glycaemia, insulin resistance and secretion based on the KORA study

  • Artikel/kapitelEngelska2018

Förlag, utgivningsår, omfång ...

  • 2018-10-02
  • Wiley,2018

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:fce6f9fa-bc98-486b-bd03-07775837df08
  • https://lup.lub.lu.se/record/fce6f9fa-bc98-486b-bd03-07775837df08URI
  • https://doi.org/10.1002/dmrr.3063DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Aims: Subclinical systemic inflammation may contribute to the development of type 2 diabetes, but its association with early progression of glycaemic deterioration in persons without diabetes has not been fully investigated. Our primary aim was to assess longitudinal associations of changes in pro-inflammatory (leukocytes, high-sensitivity C-reactive protein (hsCRP)) and anti-inflammatory (adiponectin) markers with changes in markers that assessed glycaemia, insulin resistance, and secretion (HbA1c, HOMA-IR, and HOMA-ß). Furthermore, we aimed to directly compare longitudinal with cross-sectional associations. Materials and methods: This study includes 819 initially nondiabetic individuals with repeated measurements from the Cooperative Health Research in the Region of Augsburg (KORA) S4/F4 cohort study (median follow-up: 7.1 years). Longitudinal and cross-sectional associations were simultaneously examined using linear mixed growth models. Changes in markers of inflammation were used as independent and changes in markers of glycaemia/insulin resistance/insulin secretion as dependent variables. Models were adjusted for age, sex, major lifestyle and metabolic risk factors for diabetes using time-varying variables in the final model. Results: Changes of leukocyte count were positively associated with changes in HbA1c and HOMA-ß while changes in adiponectin were inversely associated with changes in HbA1c. All examined cross-sectional associations were statistically significant; they were generally stronger and mostly directionally consistent to the longitudinal association estimates. Conclusions: Adverse changes in low-grade systemic inflammation go along with glycaemic deterioration and increased insulin secretion independently of changes in other risk factors, suggesting that low-grade inflammation may contribute to the development of hyperglycaemia and a compensatory increase in insulin secretion.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Herder, ChristianGerman Center for Diabetes Research,Heinrich Heine University Düsseldorf (författare)
  • Rutters, FemkeAmsterdam UMC - Vrije Universiteit Amsterdam (författare)
  • Carstensen-Kirberg, MarenGerman Center for Diabetes Research,Heinrich Heine University Düsseldorf (författare)
  • Huth, CorneliaHelmholtz Zentrum München,German Center for Diabetes Research (författare)
  • Stehouwer, Coen D.A.Maastricht University Medical Centre (författare)
  • Nijpels, GielAmsterdam UMC - Vrije Universiteit Amsterdam (författare)
  • Schalkwijk, CasperMaastricht University Medical Centre (författare)
  • Flyvbjerg, AllanSteno Diabetes Center Copenhagen (författare)
  • Franks, Paul W.Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups(Swepub:lu)med-plf (författare)
  • Dekker, JacquelineAmsterdam UMC - Vrije Universiteit Amsterdam (författare)
  • Meisinger, ChristaGerman Center for Diabetes Research,Helmholtz Zentrum München,Ludwig-Maximilian University of Munich (författare)
  • Koenig, WolfgangGerman Centre for Cardiovascular Research,Technical University of Munich,University of Ulm (författare)
  • Roden, MichaelGerman Center for Diabetes Research,Heinrich Heine University Düsseldorf (författare)
  • Rathmann, WolfgangHeinrich Heine University Düsseldorf,German Center for Diabetes Research (författare)
  • Peters, AnnetteGerman Center for Diabetes Research,German Centre for Cardiovascular Research,Helmholtz Zentrum München (författare)
  • Thorand, BarbaraHelmholtz Zentrum München,German Center for Diabetes Research (författare)
  • Helmholtz Zentrum MünchenGerman Center for Diabetes Research (creator_code:org_t)
  • IMI DIRECT Consortium

Sammanhörande titlar

  • Ingår i:Diabetes/Metabolism Research and Reviews: Wiley34:81520-7552

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