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- Huynh-Le, MPUniv Calif San Diego, Dept Radiat Med & Appl Sci, La Jolla, CA 92093 USA.;Univ Calif San Diego, Ctr Multimodal Imaging & Genet, La Jolla, CA 92093 USA. (author)
Polygenic hazard score is associated with prostate cancer in multi-ethnic populations
- Article/chapterEnglish2021
Publisher, publication year, extent ...
- 2021-02-23
- Springer Science and Business Media LLC,2021
Numbers
- LIBRIS-ID:oai:prod.swepub.kib.ki.se:146097305
- http://kipublications.ki.se/Default.aspx?queryparsed=id:146097305URI
- https://doi.org/10.1038/s41467-021-21287-0DOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-441002URI
Supplementary language notes
- Language:English
- Summary in:English
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Notes
- Genetic models for cancer have been evaluated using almost exclusively European data, which could exacerbate health disparities. A polygenic hazard score (PHS1) is associated with age at prostate cancer diagnosis and improves screening accuracy in Europeans. Here, we evaluate performance of PHS2 (PHS1, adapted for OncoArray) in a multi-ethnic dataset of 80,491 men (49,916 cases, 30,575 controls). PHS2 is associated with age at diagnosis of any and aggressive (Gleason score ≥ 7, stage T3-T4, PSA ≥ 10 ng/mL, or nodal/distant metastasis) cancer and prostate-cancer-specific death. Associations with cancer are significant within European (n = 71,856), Asian (n = 2,382), and African (n = 6,253) genetic ancestries (p < 10−180). Comparing the 80th/20th PHS2 percentiles, hazard ratios for prostate cancer, aggressive cancer, and prostate-cancer-specific death are 5.32, 5.88, and 5.68, respectively. Within European, Asian, and African ancestries, hazard ratios for prostate cancer are: 5.54, 4.49, and 2.54, respectively. PHS2 risk-stratifies men for any, aggressive, and fatal prostate cancer in a multi-ethnic dataset.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Urologi och njurmedicin hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Urology and Nephrology hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Medicinsk genetik hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Medical Genetics hsv//eng
Added entries (persons, corporate bodies, meetings, titles ...)
- Fan, CCUniv Calif San Diego, Ctr Multimodal Imaging & Genet, La Jolla, CA 92093 USA.,Pomeranian Med Univ, Dept Genet & Pathol, Int Hereditary Canc Ctr, Szczecin, Poland. (author)
- Karunamuni, RUniv Calif San Diego, Dept Radiat Med & Appl Sci, La Jolla, CA 92093 USA.;Univ Calif San Diego, Ctr Multimodal Imaging & Genet, La Jolla, CA 92093 USA. (author)
- Thompson, WKUniv Calif San Diego, Div Biostat, La Jolla, CA 92093 USA.;Univ Calif San Diego, Halicioglu Data Sci Inst, La Jolla, CA 92093 USA.;Univ Calif San Diego, Dept Family Med & Publ Hlth, La Jolla, CA 92093 USA. (author)
- Martinez, MEUniv Calif San Diego, Dept Family Med & Publ Hlth, Moores Canc Ctr, La Jolla, CA USA.,Stanford Univ, Sch Med, Dept Med, Div Oncol,Stanford Canc Inst, Stanford, CA 94305 USA. (author)
- Eeles, RAInst Canc Res, London, England.;Royal Marsden NHS Fdn Trust, London, England.,Univ Malaya, Dept Surg, Fac Med, Kuala Lumpur, Malaysia. (author)
- Kote-Jarai, ZInst Canc Res, London, England. (author)
- Muir, KUniv Manchester, Div Populat Hlth Hlth Serv Res & Primary Care, Oxford Rd, Manchester, Lancs, England.;Univ Warwick, Warwick Med Sch, Coventry, W Midlands, England. (author)
- Schleutker, JUniv Turku, Inst Biomed, Kiinamyllynkatu 10, FI-20014 Turku, Finland.;Turku Univ Hosp, Lab Div, Dept Med Genet, Genom, Turku, Finland. (author)
- Pashayan, NUCL, Dept Appl Hlth Res, London, England.;Univ Cambridge, Dept Oncol, Strangeways Lab, Ctr Canc Genet Epidemiol, Worts Causeway, Cambridge, England.;UCL, Dept Appl Hlth Res, London, England. (author)
- Batra, JQueensland Univ Technol, Australian Prostate Canc Res Ctr Qld, Inst Hlth & Biomed Innovat, Brisbane, Qld, Australia.;Queensland Univ Technol, Sch Biomed Sci, Brisbane, Qld, Australia.;Translat Res Inst, Brisbane, Qld, Australia. (author)
- Gronberg, HKarolinska Institutet,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden. (author)
- Neal, DEUniv Oxford, John Radcliffe Hosp, Nuffield Dept Surg Sci, Oxford, England.;Univ Cambridge, Addenbrookes Hosp, Dept Oncol, Cambridge, England.;Li Ka Shing Ctr, Cambridge Res Inst, Canc Res UK, Cambridge, England. (author)
- Donovan, JLUniv Bristol, Bristol Med Sch, Populat Hlth Sci, Bristol, Avon, England. (author)
- Hamdy, FCUniv Oxford, Nuffield Dept Surg Sci, Oxford, England.;Univ Oxford, John Radcliffe Hosp, Fac Med Sci, Oxford, England.,Katholieke Univ Leuven, Mol Endocrinol Lab, Dept Cellular & Mol Med, Leuven, Belgium. (author)
- Martin, RMUniv Bristol, Bristol Med Sch, Populat Hlth Sci, Bristol, Avon, England.;Univ Bristol, Natl Inst Hlth Res NIHR, Biomed Res Ctr, Bristol, Avon, England.;Univ Bristol, Med Res Council MRC, Integrat Epidemiol Unit, Bristol, Avon, England. (author)
- Nielsen, SFUniv Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark.;Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Dept Clin Biochem, Copenhagen, Denmark. (author)
- Nordestgaard, BGUniv Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark.;Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Dept Clin Biochem, Copenhagen, Denmark. (author)
- Wiklund, FKarolinska Institutet,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden. (author)
- Tangen, CMFred Hutchinson Canc Res Ctr, SWOG Stat Ctr, 1124 Columbia St, Seattle, WA 98104 USA.,Humangenet Tuebingen, Tubingen, Germany. (author)
- Giles, GGCanc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia.;Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Parkville, Vic, Australia.;Monash Univ, Sch Clin Sci, Precis Med, Monash Hlth, Clayton, Vic, Australia.,Univ Oxford, Nuffield Dept Surg Sci, Oxford, England. (author)
- Wolk, AlicjaUppsala universitet,Karolinska Institutet,Medicinsk epidemiologi,Karolinska Inst, Inst Environm Med, Div Nutr Epidemiol, Stockholm, Sweden.(Swepub:uu)alwol516 (author)
- Albanes, DNCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA. (author)
- Travis, RCUniv Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England. (author)
- Blot, WJVanderbilt Univ, Med Ctr, Dept Med, Div Epidemiol, Nashville, TN USA.;Int Epidemiol Inst, Rockville, MD USA. (author)
- Zheng, WVanderbilt Univ, Med Ctr, Dept Med, Div Epidemiol, Nashville, TN USA. (author)
- Sanderson, MMeharry Med Coll, Dept Family & Community Med, Nashville, TN 37208 USA. (author)
- Stanford, JLFred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.;Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA. (author)
- Mucci, LAHarvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA. (author)
- West, CMLUniv Manchester, Manchester Acad Hlth Sci Ctr, Christie Hosp NHS Fdn Trust, Radiotherapy Related Res,Div Canc Sci, Manchester, Lancs, England.,Univ Rennes, Irset Inst Rech Sante Environm & Travail, INSERM, EHESP,UMR S 1085, Rennes, France. (author)
- Kibel, ASBrigham & Womens Hosp, Div Urol Surg, 75 Francis St, Boston, MA 02115 USA. (author)
- Cussenot, OSorbonne Univ, AP HP, GRC 5, 4 Rue Chine, Paris, France.;Tenon Hosp, CeRePP, Paris, France. (author)
- Berndt, SINCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA. (author)
- Koutros, SNCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA. (author)
- Sorensen, KDAarhus Univ Hosp, Dept Mol Med, Aarhus, Denmark.;Aarhus Univ, Dept Clin Med, Aarhus, Denmark. (author)
- Cybulski, C (author)
- Grindedal, EMOslo Univ Hosp, Dept Med Genet, Oslo, Norway. (author)
- Menegaux, FUniv Paris Saclay, Univ Paris Sud, Ctr Res Epidemiol & Populat Hlth CESP, Canc & Environm Grp,INSERM, Villejuif, France.;Paris Sud Univ, UMRS 1018, Villejuif, France. (author)
- Khaw, KTUniv Cambridge, Clin Gerontol Unit, Cambridge, England. (author)
- Park, JYH Lee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, Tampa, FL USA. (author)
- Ingles, SAUniv Southern Calif, Keck Sch Med, Dept Prevent Med, Norris Comprehens Canc Ctr, Los Angeles, CA 90007 USA. (author)
- Maier, C (author)
- Hamilton, RJPrincess Margaret Canc Ctr, Dept Surg Oncol, Toronto, ON, Canada.;Univ Toronto, Dept Surg Urol, Toronto, ON, Canada. (author)
- Thibodeau, SNMayo Clin, Dept Lab Med & Pathol, Rochester, MN USA. (author)
- Rosenstein, BSIcahn Sch Med Mt Sinai, Dept Radiat Oncol, One Gustave L Levy Pl, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, One Gustave L Levy Pl, New York, NY 10029 USA. (author)
- Lu, YJQueen Mary Univ London, Barts Canc Inst, John Vane Sci Ctr, Ctr Mol Oncol, Charterhouse Sq, London, England. (author)
- Watya, SUro Care, Kampala, Uganda. (author)
- Vega, AFdn Publ Galega Medicina Xen, Santiago De Compostela, Spain.;Inst Invest Sanitaria Santiago de Compostela, Santiago De Compostela, Spain.;Ctr Invest Red Enfermedades Raras CIBERER, Santiago De Compostela, Spain. (author)
- Kogevinas, MISGlobal, Barcelona, Spain.;IMIM Hosp del Mar Med Res Inst, Barcelona, Spain.;Univ Pompeu Fabra UPF, Barcelona, Spain. (author)
- Penney, KLHarvard Med Sch, Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA. (author)
- Huff, CUniv Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. (author)
- Teixeira, MRPortuguese Oncol Inst Porto IPO Porto, Dept Genet, Porto, Portugal.;Univ Porto, Biomed Sci Inst ICBAS, Porto, Portugal. (author)
- Multigner, L (author)
- Leach, RJUniv Texas Hlth Sci Ctr San Antonio, Dept Urol, Mays Canc Ctr, San Antonio, TX 78229 USA. (author)
- Cannon-Albright, LUniv Utah, Sch Med, Dept Internal Med, Div Epidemiol, Salt Lake City, UT USA.;George E Wahlen Dept Vet Affairs Med Ctr, Salt Lake City, UT USA. (author)
- Brenner, HGerman Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany.;German Canc Res Ctr, German Canc Consortium DKTK, Heidelberg, Germany.;German Canc Res Ctr, Div Prevent Oncol, Neuenheimer Feld 460, Heidelberg, Germany.;Natl Ctr Tumor Dis NCT, Neuenheimer Feld 460, Heidelberg, Germany. (author)
- John, EM (author)
- Kaneva, RMed Univ Sofia, Dept Med Chem & Biochem, Mol Med Ctr, Sofia, Bulgaria. (author)
- Logothetis, CJUniv Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, Houston, TX 77030 USA. (author)
- Neuhausen, SLCity Hope Natl Med Ctr, Beckman Res Inst, Dept Populat Sci, Duarte, CA USA. (author)
- De Ruyck, KUniv Ghent, Fac Med & Hlth Sci, Basic Med Sci, Ghent, Belgium. (author)
- Pandha, HUniv Surrey, Guildford, Surrey, England. (author)
- Razack, A (author)
- Newcomb, LFFred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.;Univ Washington, Dept Urol, Seattle, WA 98195 USA. (author)
- Fowke, JHVanderbilt Univ, Med Ctr, Dept Med & Urol Surg, Nashville, TN USA.;Univ Tennessee, Hlth Sci Ctr, Dept Prevent Med, Div Epidemiol, Memphis, TN USA. (author)
- Gamulin, MUniv Zagreb, Sch Med, Univ Hosp Ctr Zagreb, Dept Oncol, Zagreb, Croatia. (author)
- Usmani, NUniv Alberta, Cross Canc Inst, Dept Oncol, Edmonton, AB, Canada.;Cross Canc Inst, Div Radiat Oncol, Edmonton, AB, Canada. (author)
- Claessens, F (author)
- Gago-Dominguez, MComplejo Hosp Univ Santiago, Inst Invest Sanitaria Santiago de Compostela IDIS, Galician Fdn Genom Med, Genom Med Grp,Serv Galego Saude,SERGAS, Santiago De Compostela, Spain.;Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA. (author)
- Townsend, PAUniv Manchester, NIHR Manchester Biomed Res Ctr,Div Canc Sci, Manchester Acad Hlth Sci Ctr,Fac Biol Med & Hlth, Manchester Canc Res Ctr,Hlth Innovat Manchester, Manchester, Lancs, England. (author)
- Bush, WSCase Western Reserve Univ, Dept Populat & Quantitat Hlth Sci, Cleveland Inst Computat Biol, Cleveland, OH 44106 USA. (author)
- Roobol, MJErasmus MC, Dept Clin Chem, Rotterdam, Netherlands. (author)
- Parent, MEUniv Turku, Inst Biomed, Kiinamyllynkatu 10, FI-20014 Turku, Finland.;Inst Natl Rech Sci, Ctr Armand Frappier Sante Biotechnol, Epidemiol & Biostat Unit, Laval, PQ, Canada.;Univ Montreal, Sch Publ Hlth, Dept Social & Prevent Med, Montreal, PQ, Canada. (author)
- Hu, JJUniv Miami, Sch Med, Sylvester Comprehens Canc Ctr, Miami, FL USA. (author)
- Mills, IG (author)
- Andreassen, OAOslo Univ Hosp, KG Jebsen Ctr, NORMENT, Oslo, Norway.;Univ Oslo, Oslo, Norway. (author)
- Dale, AMUniv Calif San Diego, Ctr Multimodal Imaging & Genet, La Jolla, CA 92093 USA.;Univ Calif San Diego, Dept Radiol, La Jolla, CA 92093 USA. (author)
- Seibert, TMUniv Calif San Diego, Dept Radiat Med & Appl Sci, La Jolla, CA 92093 USA.;Univ Calif San Diego, Ctr Multimodal Imaging & Genet, La Jolla, CA 92093 USA.;Univ Calif San Diego, Dept Radiol, La Jolla, CA 92093 USA.;Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA. (author)
- Univ Calif San Diego, Dept Radiat Med & Appl Sci, La Jolla, CA 92093 USA.;Univ Calif San Diego, Ctr Multimodal Imaging & Genet, La Jolla, CA 92093 USA.Univ Calif San Diego, Ctr Multimodal Imaging & Genet, La Jolla, CA 92093 USA. (creator_code:org_t)
Related titles
- In:Nature communications: Springer Science and Business Media LLC12:1, s. 1236-2041-1723
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- https://www.nature.com/articles/s41467-021-21287-0.pdf
- https://doi.org/10.1038/s41467-021-21287-0Fulltext
- https://uu.diva-portal.org/smash/get/diva2:1546791/FULLTEXT01.pdffulltext:print
- http://kipublications.ki.se/Default.aspx?queryparsed=id:146097305
- https://doi.org/10.1038/s41467-021-21287-0
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-441002
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