Lifestyle-related risk factors and their cumulative associations with hippocampal and total grey matter volume across the adult lifespan: a pooled analysis in the European Lifebrain consortium

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Lifestyle-related risk factors and their cumulative associations with hippocampal and total grey matter volume across the adult lifespan : a pooled analysis in the European Lifebrain consortium

Binnewies, Julia (author): Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam Neuroscience, Mood, Anxiety, Psychosis, Sleep & Stress program, Amsterdam, Netherlands

Nawijn, Laura (author): Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam Neuroscience, Mood, Anxiety, Psychosis, Sleep & Stress program, Amsterdam, Netherlands

Brandmaier, Andreas M. (author): Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany; Department of Psychology, MSB Medical School Berlin, Berlin, Germany

Baaré, William F.C. (author): Danish Research Centre for Magnetic Resonance, centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital - Amager and Hvidovre, Copenhagen, Denmark

Boraxbekk, Carl-Johan, 1980- (author): Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Institutionen för strålningsvetenskaper,Danish Research Centre for Magnetic Resonance, centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital - Amager and Hvidovre, Copenhagen, Denmark; Institute for Clinical Medicine, Faculty of Medical and Health Sciences, University of Copenhagen, Copenhagen, Denmark; Institute of Sports Medicine Copenhagen (ISMC) and Department of Neurology, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark

Demnitz, Naiara (author): Danish Research Centre for Magnetic Resonance, centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital - Amager and Hvidovre, Copenhagen, Denmark

Drevon, Christian A. (author): Vitas Ltd. Oslo Science Park & Department of Nutrition, IMB, University of Oslo, Norway

Fjell, Anders M. (author): Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Norway; Computational Radiology and Artificial Intelligence, Department of Radiology and Nuclear Medicine, Oslo University Hospital, Norway

Lindenberger, Ulman (author): Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany

Madsen, Kathrine Skak (author): Danish Research Centre for Magnetic Resonance, centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital - Amager and Hvidovre, Copenhagen, Denmark

Nyberg, Lars, 1966- (author): Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI)

Topiwala, Anya (author): Nuffield Department of Population Health, Big Data Institute, University of Oxford, Oxford, United Kingdom

Walhovd, Kristine B. (author): Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Norway; Computational Radiology and Artificial Intelligence, Department of Radiology and Nuclear Medicine, Oslo University Hospital, Norway

Ebmeier, Klaus P. (author): Department of Psychiatry, University of Oxford, United Kingdom

Penninx, Brenda W.J.H. (author): Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam Neuroscience, Mood, Anxiety, Psychosis, Sleep & Stress program, Amsterdam, Netherlands

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Elsevier, 2023
2023
English.
In: Brain Research Bulletin. - : Elsevier. - 0361-9230 .- 1873-2747. ; 200

Related links:: https://doi.org/10.1...; show more...; https://umu.diva-por... (primary) (Raw object); https://urn.kb.se/re...; https://doi.org/10.1...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Background: Lifestyle-related risk factors, such as obesity, physical inactivity, short sleep, smoking and alcohol use, have been associated with low hippocampal and total grey matter volumes (GMV). However, these risk factors have mostly been assessed as separate factors, leaving it unknown if variance explained by these factors is overlapping or additive. We investigated associations of five lifestyle-related factors separately and cumulatively with hippocampal and total GMV, pooled across eight European cohorts.Methods: We included 3838 participants aged 18–90 years from eight cohorts of the European Lifebrain consortium. Using individual person data, we performed cross-sectional meta-analyses on associations of presence of lifestyle-related risk factors separately (overweight/obesity, physical inactivity, short sleep, smoking, high alcohol use) as well as a cumulative unhealthy lifestyle score (counting the number of present lifestyle-related risk factors) with FreeSurfer-derived hippocampal volume and total GMV. Lifestyle-related risk factors were defined according to public health guidelines.Results: High alcohol use was associated with lower hippocampal volume (r = −0.10, p = 0.021), and overweight/obesity with lower total GMV (r = −0.09, p = 0.001). Other lifestyle-related risk factors were not significantly associated with hippocampal volume or GMV. The cumulative unhealthy lifestyle score was negatively associated with total GMV (r = −0.08, p = 0.001), but not hippocampal volume (r = −0.01, p = 0.625).Conclusions: This large pooled study confirmed the negative association of some lifestyle-related risk factors with hippocampal volume and GMV, although with small effect sizes. Lifestyle factors should not be seen in isolation as there is evidence that having multiple unhealthy lifestyle factors is associated with a linear reduction in overall brain volume.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)

Keyword

Alcohol
Brain structure
Obesity
Physical activity
Sleep
Smoking

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By the author/editor: Binnewies, Julia; Nawijn, Laura; Brandmaier, Andr ...; Baaré, William F ...; Boraxbekk, Carl- ...; Demnitz, Naiara; show more...; Drevon, Christia ...; Fjell, Anders M.; Lindenberger, Ul ...; Madsen, Kathrine ...; Nyberg, Lars, 19 ...; Topiwala, Anya; Walhovd, Kristin ...; Ebmeier, Klaus P ...; Penninx, Brenda ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

Articles in the publication: Brain Research B ...

By the university: Umeå University

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