SwePub
Tyck till om SwePub Sök här!
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:DiVA.org:uu-225078"
 

Search: onr:"swepub:oai:DiVA.org:uu-225078" > Vasostatin-1 antige...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Vasostatin-1 antigenic epitope mapping for induction of cellular and humoral immune responses to chromogranin A autoantigen in NOD mice

Nikoopour, Enayat (author)
Cheung, Rebecca (author)
Bellemore, Stacey (author)
show more...
Krougly, Olga (author)
Lee-Chan, Edwin (author)
Stridsberg, Mats (author)
Uppsala universitet,Biokemisk endokrinologi
Singh, Bhagirath (author)
show less...
 (creator_code:org_t)
2014-01-20
2014
English.
In: European Journal of Immunology. - : Wiley. - 0014-2980 .- 1521-4141. ; 44:4, s. 1170-1180
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • The chromogranin A (ChgA) 29-42 sequence is the antigenic epitope for the BDC2.5 CD4(+) T-cell receptor in NOD mice (H-2(g7)). We have now characterized the binding register of the ChgA 29-42 peptide for the I-A(g7) molecule. Truncation of the peptide demonstrated that the KCVLEVISD sequence 34-42 is the binding register and extension of this sequence by flanking residues increased its binding affinity and antigenic capacity. We employed anti-ChgA peptide antibodies generated against different fragments of ChgA for immunostaining of pancreatic islet sections from NOD mice. A strong immuno-staining pattern was observed for the ChgA 17-38 peptide antibodies that overlap with the ChgA 29-42 sequence. Moreover, sera from diabetic NOD mice showed elevated titers of autoantibodies to the ChgA 29-42 peptide. These findings indicate that peptides from the N-terminal region of ChgA are able to induce cellular and humoral immune responses in NOD mice.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Immunology in the medical area (hsv//eng)

Keyword

BDC2
5 T cells
Chromogranin A
I-A(g7) peptide binding motif
Type 1 diabetes

Publication and Content Type

ref (subject category)
art (subject category)

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Search outside SwePub

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view