onr:"swepub:oai:lup.lub.lu.se:231c22e5-d5cd-4c22-a9d7-7cbad7dd2e90"
Search: onr:"swepub:oai:lup.lub.lu.se:231c22e5-d5cd-4c22-a9d7-7cbad7dd2e90" > Three exceptional I...
- 1 of 1
- Previous record
- Next record
- To hitlist
Three exceptional IgH/myc-translocation-carrying rat immunocytomas have breakpoints 50 to 80 kb 5' of c-myc
-
- Axelson, H (author)
- Karolinska Institutet,Lund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine
- Panda, C K (author)
- Klein, G (author)
- (creator_code:org_t)
- 1994
- 1994
- English.
- In: International Journal of Cancer. - 0020-7136. ; 56:3, s. 21-418
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- The spontaneously arising immunocytoma of the Louvain rat (RIC) carries a consistent chromosomal translocation between chromosomes 6 and 7. This translocation juxtaposes immunoglobulin heavy chain and c-myc sequences. In an earlier study on 14 RIC tumors, we found that the translocation breakpoint is located within 1.5 kb immediately upstream of c-myc in 10 of the tumors. Here we describe 3 exceptional tumors that had no rearrangement within 20 kb 5' of c-myc. Using pulsed-field gel electrophoresis we show that the translocation breakpoints in these tumors are located 50-80 kb 5' of c-myc and that c-myc rearranges to the 3' end of the IgH cluster.
Keyword
- Animals
- Cell Line
- Chromosome Mapping
- DNA, Neoplasm
- Genes, Immunoglobulin
- Genes, myc
- Immunoglobulin Heavy Chains
- Leukemia, Lymphocytic, Chronic, B-Cell
- Multigene Family
- Rats
- Rats, Inbred Strains
- Restriction Mapping
- Translocation, Genetic
- Tumor Cells, Cultured
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
- International Journal of Cancer (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Axelson, H
- Panda, C K
- Klein, G
- Articles in the publication
- International Jo ...
- By the university
- Lund University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
