Search: onr:"swepub:oai:lup.lub.lu.se:2aa64163-6feb-45fd-ab89-136e0f912ba9" >
A genome-wide assoc...
A genome-wide association study identifies risk loci for childhood acute lymphoblastic leukemia at 10q26.13 and 12q23.1
-
- Vijayakrishnan, Jayaram (author)
- Institute of Cancer Research London
-
- Kumar, R. (author)
- German Cancer Research Centre
-
- Henrion, M. Y.R. (author)
- Institute of Cancer Research London
-
show more...
-
- Moorman, A V (author)
- University of Newcastle upon Tyne
-
- Rachakonda, P Sivaramakrishna (author)
- German Cancer Research Centre
-
- Hosen, Ismail (author)
- German Cancer Research Centre
-
- Da Silva Filho, M. I. (author)
- German Cancer Research Centre
-
- Holroyd, A (author)
- Institute of Cancer Research London
-
- Dobbins, Sara E. (author)
- Institute of Cancer Research London
-
- Koehler, Rolf (author)
- Heidelberg University
-
- Thomsen, H. (author)
- German Cancer Research Centre
-
- Irving, Julie A (author)
- University of Newcastle upon Tyne
-
- Allan, J M (author)
- University of Newcastle upon Tyne
-
- Lightfoot, Tracy (author)
- University of York
-
- Roman, Erika (author)
- University of York
-
- Kinsey, Sally E (author)
- Leeds General Infirmary
-
- Sheridan, Eamonn (author)
- University of Leeds
-
- Thompson, P. D. (author)
- University of Manchester
-
- Hoffmann, P (author)
- University of Bonn,University Hospital Basel
-
- Nöthen, M M (author)
- University of Bonn
-
- Heilmann-Heimbach, Stefanie (author)
- University of Bonn
-
- Jöckel, Karl-Heinz (author)
- University Hospital Essen
-
- Greaves, M. W. (author)
- Institute of Cancer Research London
-
- Harrison, C J (author)
- University of Newcastle upon Tyne
-
- Bartram, C R (author)
- Heidelberg University
-
- Schrappe, Martin (author)
- University Medical Center Schleswig-Holstein
-
- Stanulla, Martin (author)
- Hannover Medical School
-
- Hemminki, K. (author)
- Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,German Cancer Research Centre
-
- Houlston, R S (author)
- Institute of Cancer Research London
-
show less...
-
(creator_code:org_t)
- 2016-10-03
- 2017
- English 7 s.
-
In: Leukemia. - : Springer Science and Business Media LLC. - 0887-6924 .- 1476-5551. ; 31:3, s. 573-579
- Related links:
-
http://dx.doi.org/10... (free)
-
show more...
-
https://www.nature.c...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Genome-wide association studies (GWASs) have shown that common genetic variation contributes to the heritable risk of childhood acute lymphoblastic leukemia (ALL). To identify new susceptibility loci for the largest subtype of ALL, B-cell precursor ALL (BCP-ALL), we conducted a meta-analysis of two GWASs with imputation using 1000 Genomes and UK10K Project data as reference (totaling 1658 cases and 7224 controls). After genotyping an additional 2525 cases and 3575 controls, we identify new susceptibility loci for BCP-ALL mapping to 10q26.13 (rs35837782, LHPP, P=1.38 × 10-11) and 12q23.1 (rs4762284, ELK3, P=8.41 × 10-9). We also provide confirmatory evidence for the existence of independent risk loci at 9p21.3, but show that the association marked by rs77728904 can be accounted for by linkage disequilibrium with the rare high-impact CDKN2A p.Ala148Thr variant rs3731249. Our data provide further insights into genetic susceptibility to ALL and its biology.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
-
Leukemia
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Vijayakrishnan, ...
-
Kumar, R.
-
Henrion, M. Y.R.
-
Moorman, A V
-
Rachakonda, P Si ...
-
Hosen, Ismail
-
show more...
-
Da Silva Filho, ...
-
Holroyd, A
-
Dobbins, Sara E.
-
Koehler, Rolf
-
Thomsen, H.
-
Irving, Julie A
-
Allan, J M
-
Lightfoot, Tracy
-
Roman, Erika
-
Kinsey, Sally E
-
Sheridan, Eamonn
-
Thompson, P. D.
-
Hoffmann, P
-
Nöthen, M M
-
Heilmann-Heimbac ...
-
Jöckel, Karl-Hei ...
-
Greaves, M. W.
-
Harrison, C J
-
Bartram, C R
-
Schrappe, Martin
-
Stanulla, Martin
-
Hemminki, K.
-
Houlston, R S
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Medical Genetics
- Articles in the publication
-
Leukemia
- By the university
-
Lund University