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Analysis of 153 115 patients with hematological malignancies refines the spectrum of familial risk

Sud, Amit (author)
German Cancer Research Centre
Chattopadhyay, Subhayan (author)
Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,Heidelberg University
Thomsen, Hauke (author)
German Cancer Research Centre
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Sundquist, Kristina (author)
Lund University,Lunds universitet,Allmänmedicin, kardiovaskulär epidemiologi och levnadsvanor,Forskargrupper vid Lunds universitet,Allmänmedicin och klinisk epidemiologi,Family Medicine, Cardiovascular Epidemiology and Lifestyle,Lund University Research Groups,Family Medicine and Clinical Epidemiology,Shimane University,Icahn School of Medicine at Mount Sinai
Sundquist, Jan (author)
Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,Icahn School of Medicine at Mount Sinai,Shimane University
Houlston, Richard (author)
Institute of Cancer Research London
Hemminki, Kari (author)
Lund University,Lunds universitet,Allmänmedicin, kardiovaskulär epidemiologi och levnadsvanor,Forskargrupper vid Lunds universitet,Allmänmedicin och klinisk epidemiologi,Family Medicine, Cardiovascular Epidemiology and Lifestyle,Lund University Research Groups,Family Medicine and Clinical Epidemiology,German Cancer Research Centre
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 (creator_code:org_t)
2019-08-08
2019
English 10 s.
In: Blood. - : American Society of Hematology. - 1528-0020 .- 0006-4971. ; 134:12, s. 960-969
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Estimating familial cancer risks is clinically important in being able to discriminate between individuals in the population at differing risk for malignancy. To gain insight into the familial risk for the different hematological malignancies and their possible inter-relationship, we analyzed data on more than 16 million individuals from the Swedish Family-Cancer Database. After identifying 153 115 patients diagnosed with a primary hematological malignancy, we quantified familial relative risks (FRRs) by calculating standardized incident ratios (SIRs) in 391 131 of their first-degree relatives. The majority of hematological malignancies showed increased FRRs for the same tumor type, with the highest FRRs being observed for mixed cellularity Hodgkin lymphoma (SIR, 16.7), lymphoplasmacytic lymphoma (SIR, 15.8), and mantle cell lymphoma (SIR, 13.3). There was evidence for pleiotropic relationships; notably, chronic lymphocytic leukemia was associated with an elevated familial risk for other B-cell tumors and myeloproliferative neoplasms. Collectively, these data provide evidence for shared etiological factors for many hematological malignancies and provide information for identifying individuals at increased risk, as well as informing future gene discovery initiatives.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Hematologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Hematology (hsv//eng)

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