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Functional homology...
Functional homology between N-myc and c-myc in murine plasmacytomagenesis : plasmacytoma development in N-myc transgenic mice
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- Wang, Y (author)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups
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Sugiyama, H (author)
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- Axelson, H (author)
- Karolinska Institutet,Lund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine
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Panda, C K (author)
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Babonits, M (author)
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Ma, A (author)
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Steinberg, J M (author)
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Alt, F W (author)
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Klein, G (author)
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Wiener, F (author)
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(creator_code:org_t)
- 1992
- 1992
- English 7 s.
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In: Oncogene. - 0950-9232. ; 7:6, s. 7-1241
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https://lup.lub.lu.s...
Abstract
Subject headings
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- Mouse plasmacytomas induced by pristane oil alone, or in combination with Abelson murine leukemia virus (A-MuLV), regularly carry one of three alternative chromosomal translocations that juxtapose c-myc to immunoglobulin heavy- or light-chain loci. E mu-c-myc transgenic mice develop translocation-free plasmacytomas after induction by pristane oil and/or A-MuLV [Sugiyama, H., Silva, S., Wang, Y., Weber, G., Babonits, M., Rosen, A., Wiener, F. & Klein, G. (1990). Int. J. Cancer, 46, 845-852]. In order to test whether another member of the myc family, N-myc, could play a similar role as c-myc, we treated E mu-N-myc transgenic mice with pristane and helper-free A-MuLV. Of 20 mice that received a single pristane injection followed by A-MuLV, 17 developed plasmacytomas with a mean latency period of 54 +/- 20 days. In a corresponding group that only received a single pristane injection, five out of six transgenic mice developed plasmacytomas with a mean latency period of 142 +/- 32 days. However, after three monthly injections of pristane, all 15 transgenic mice developed plasmacytomas with a mean latency period of 128 +/- 20 days. All plasmacytomas expressed the N-myc transgene, while none of them expressed either c-myc or endogenous N-myc. None of the tumors carried the usual plasmacytoma-associated translocations.
Keyword
- Abelson murine leukemia virus
- Animals
- Carcinogens
- DNA
- DNA, Neoplasm
- Enhancer Elements, Genetic
- Genes, Immunoglobulin
- Genes, myc
- Immunoglobulin Heavy Chains
- Immunoglobulin Light Chains
- Introns
- Mice
- Mice, Transgenic
- Plasmacytoma
- RNA
- RNA, Neoplasm
- Terpenes
- Translocation, Genetic
Publication and Content Type
- art (subject category)
- ref (subject category)
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Oncogene
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- By the author/editor
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Wang, Y
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Sugiyama, H
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Axelson, H
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Panda, C K
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Babonits, M
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Ma, A
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show more...
-
Steinberg, J M
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Alt, F W
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Klein, G
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Wiener, F
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show less...
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Oncogene
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Lund University