Sökning: onr:"20194187" > Exome sequencing of...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 04935naa a22008893a 4500 | |
001 | 20194187 | |
003 | SE-LIBR | |
005 | 20170323181253.0 | |
007 | cr|||||||||||| | |
008 | 170323s2015 sw |||| o |||| ||eng c | |
024 | 7 | a http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2687992 uri |
024 | 7 | a urn:nbn:se:uu:diva-2687992 urn |
024 | 7 | a 10.1101/gr.194449.1152 doi |
040 | a S | |
041 | 0 | a eng |
042 | 9 EPLK | |
100 | 1 | a Elvers, Ingegerd4 aut |
245 | 1 0 | a Exome sequencing of lymphomas from three dog breeds reveals somatic mutation patterns reflecting genetic backgroundh [Elektronisk resurs] |
260 | c 2015 | |
500 | a Published | |
500 | a NIH (National Institute of Health) [U54 HG003067-08] | |
500 | a EU, Europeiska forskningsrådet | |
500 | a Vetenskapsrådet | |
500 | a EU, Europeiska forskningsrådet | |
506 | 0 | a gratis |
520 | a Lymphoma is the most common hematological malignancy in developed countries. Outcome is strongly determined by molecular subtype, reflecting a need for new and improved treatment options. Dogs spontaneously develop lymphoma, and the predisposition of certain breeds indicates genetic risk factors. Using the dog breed structure, we selected three lymphoma predisposed breeds developing primarily T-cell (boxer), primarily B-cell (cocker spaniel), and with equal distribution of B- and T-cell lymphoma (golden retriever), respectively. We investigated the somatic mutations in B- and T-cell lymphomas from these breeds by exome sequencing of tumor and normal pairs. Strong similarities were evident between B-cell lymphomas from golden retrievers and cocker spaniels, with recurrent mutations in TRAF3-MAP3K14 (28% of all cases), FBXW7 (25%), and POT1 (17%). The FBXW7 mutations recurrently occur in a specific codon; the corresponding codon is recurrently mutated in human cancer. In contrast, T-cell lymphomas from the predisposed breeds, boxers and golden retrievers, show little overlap in their mutation pattern, sharing only one of their 15 most recurrently mutated genes. Boxers, which develop aggressive T-cell lymphomas, are typically mutated in the PTEN-mTOR pathway. T-cell lymphomas in golden retrievers are often less aggressive, and their tumors typically showed mutations in genes involved in cellular metabolism. We identify genes with known involvement in human lymphoma and leukemia, genes implicated in other human cancers, as well as novel genes that could allow new therapeutic options. | |
650 | 7 | a Natural Sciences2 hsv |
650 | 7 | a Biological Sciences2 hsv |
650 | 7 | a Biochemistry and Molecular Biology2 hsv |
650 | 7 | a Naturvetenskap2 hsv0 264446 |
650 | 7 | a Biologiska vetenskaper2 hsv |
650 | 7 | a Biokemi och molekylärbiologi2 hsv |
650 | 7 | a Medical and Health Sciences2 hsv |
650 | 7 | a Clinical Medicine2 hsv |
650 | 7 | a Cancer and Oncology2 hsv |
650 | 7 | a Medicin och hälsovetenskap2 hsv |
650 | 7 | a Klinisk medicin2 hsv |
650 | 7 | a Cancer och onkologi2 hsv |
700 | 1 | a Turner-Maier, Jason4 aut |
700 | 1 | a Swofford, Ross4 aut |
700 | 1 | a Koltookian, Michele4 aut |
700 | 1 | a Johnson, Jeremy4 aut |
700 | 1 | a Stewart, Chip4 aut |
700 | 1 | a Zhang, Cheng-Zhong4 aut |
700 | 1 | a Schumacher, Steven E.4 aut |
700 | 1 | a Beroukhim, Rameen4 aut |
700 | 1 | a Rosenberg, Mara4 aut |
700 | 1 | a Thomas, Rachael4 aut |
700 | 1 | a Mauceli, Evan4 aut |
700 | 1 | a Getz, Gad4 aut |
700 | 1 | a Di Palma, Federica4 aut |
700 | 1 | a Modiano, Jaime F.4 aut |
700 | 1 | a Breen, Matthew4 aut |
700 | 1 | a Lindblad-Toh, Kerstin4 aut0 268427 |
700 | 1 | a Alfoeldi, Jessica4 aut |
710 | 1 2 | a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl |
772 | 1 8 | i channel recordw 19753896 |
773 | 0 8 | i Värdpublikationt Genome Researchg 25:11, 1634-1645x 1088-9051 |
856 | 4 0 | u http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-268799 |
856 | 4 0 | u http://dx.doi.org/10.1101/gr.194449.115 |
856 | 4 0 | u http://uu.diva-portal.org/smash/get/diva2:881108/FULLTEXT01 |
900 | 1 s | 6 700a Toh, Kerstin Lindblad-u Lindblad-Toh, Kerstin |
950 | k | 6 650a Atomerw hu Naturvetenskap |
950 | k | 6 650a Experimentw hu Naturvetenskap |
950 | k | 6 650a Fysikw hu Naturvetenskap |
950 | k | 6 650a Kemiw hu Naturvetenskap |
950 | k | 6 650a Kloningw hu Naturvetenskap |
950 | k | 6 650a Laboratorierw hu Naturvetenskap |
950 | k | 6 650a Marinbiologiw hu Naturvetenskap |
950 | k | 6 650a Matematikw hu Naturvetenskap |
950 | k | 6 650a Medicinska experimentw hu Naturvetenskap |
950 | k | 6 650a Tyngdlagenw hu Naturvetenskap |
950 | k | 6 650a Utvecklingsläraw hu Naturvetenskap |
841 | 5 APISa x ab 170323||0000|||||001||||||000000e 1 | |
024 | 7 | 5 APISa urn:nbn:se:uu:diva-2687992 urn |
852 | 5 APISb APIS | |
856 | 4 0 | 5 APISu http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-268799 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
Kopiera och spara länken för att återkomma till aktuell vy