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Sökning: onr:"swepub:oai:DiVA.org:umu-191192" > Spirometric phenoty...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00014385naa a2201009 4500
001oai:DiVA.org:umu-191192
003SwePub
008220111s2021 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:149174473
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1911922 URI
0247 a https://doi.org/10.1183/23120541.00457-20212 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1491744732 URI
040 a (SwePub)umud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Wang, Gangu Karolinska Institutet4 aut
2451 0a Spirometric phenotypes from early childhood to young adulthood :b a Chronic Airway Disease Early Stratification study
264 c 2021-09-29
264 1b ERS Publications,c 2021
338 a electronic2 rdacarrier
520 a Background: The prevalences of obstructive and restrictive spirometric phenotypes, and their relation to early-life risk factors from childhood to young adulthood remain poorly understood. The aim was to explore these phenotypes and associations with well-known respiratory risk factors across ages and populations in European cohorts.Methods: We studied 49334 participants from 14 population-based cohorts in different age groups (⩽10, >10–15, >15–20, >20–25 years, and overall, 5–25 years). The obstructive phenotype was defined as forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) z-score less than the lower limit of normal (LLN), whereas the restrictive phenotype was defined as FEV1/FVC z-score ⩾LLN, and FVC z-score Results: The prevalence of obstructive and restrictive phenotypes varied from 3.2–10.9% and 1.8–7.7%, respectively, without clear age trends. A diagnosis of asthma (adjusted odds ratio (aOR=2.55, 95% CI 2.14–3.04), preterm birth (aOR=1.84, 1.27–2.66), maternal smoking during pregnancy (aOR=1.16, 95% CI 1.01–1.35) and family history of asthma (aOR=1.44, 95% CI 1.25–1.66) were associated with a higher prevalence of obstructive, but not restrictive, phenotype across ages (5–25 years). A higher current body mass index (BMI was more often observed in those with the obstructive phenotype but less in those with the restrictive phenotype (aOR=1.05, 95% CI 1.03–1.06 and aOR=0.81, 95% CI 0.78–0.85, per kg·m−2 increase in BMI, respectively). Current smoking was associated with the obstructive phenotype in participants older than 10 years (aOR=1.24, 95% CI 1.05–1.46).Conclusion: Obstructive and restrictive phenotypes were found to be relatively prevalent during childhood, which supports the early origins concept. Several well-known respiratory risk factors were associated with the obstructive phenotype, whereas only low BMI was associated with the restrictive phenotype, suggesting different underlying pathobiology of these two phenotypes.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Lungmedicin och allergi0 (SwePub)302192 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Respiratory Medicine and Allergy0 (SwePub)302192 hsv//eng
7001 a Hallberg, Jennyu Karolinska Institutet4 aut
7001 a Charalampopoulos, Dimitriosu MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom4 aut
7001 a Sanahuja, Maribel Casasu ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain4 aut
7001 a Breyer-Kohansal, Robabu Ludwig Boltzmann Institute for Lung Health, Vienna, Austria4 aut
7001 a Langhammer, Arnulfu Dept of Public Health and Nursing, Faculty of Medicine and Health Sciences, HUNT Research Centre, Norwegian University of Science and Technology (NTNU), Levanger, Norway4 aut
7001 a Granell, Raquelu MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom4 aut
7001 a Vonk, Judith M.u Dept of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, University of Groningen, Groningen, Netherlands4 aut
7001 a Mian, Annemieku The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands; Division of Respiratory Medicine and Allergology, and Neonatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands4 aut
7001 a Olvera, Núriau Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Institut d’investigacions biomediques August Pi I Sunyer, Barcelona, Spain4 aut
7001 a Laustsen, Lisbeth Mølgaardu Dept of Public Health, Environment Occupation and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark4 aut
7001 a Rönmark, Evau Umeå universitet,Avdelningen för hållbar hälsa4 aut0 (Swepub:umu)evra0004
7001 a Abellan, Aliciau Karolinska Institutet4 aut
7001 a Agusti, Alvaru Institut d’investigacions biomediques August Pi I Sunyer, Barcelona, Spain; Respiratory Institute, Hospital Clinic, Univ. Barcelona, Barcelona, Spain; CIBERESP (ISCiii), Barcelona, Spain4 aut
7001 a Arshad, Syed Hasanu David Hide Asthma and Allergy Research Centre, Newport, United Kingdom; NIHR Southampton Biomedical Research Centre, University Hospitals Southampton NHS Foundation Trust, Southampton, United Kingdom; Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom4 aut
7001 a Bergström, Annau Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Occupational and Environmental Medicine, Region Stockholm, Stockholm, Sweden4 aut
7001 a Boezen, H. Marikeu Dept of Epidemiology, University Medical Center Groningen, Groningen, Netherlands4 aut
7001 a Breyer, Marie-Kathrinu Ludwig Boltzmann Institute for Lung Health, Vienna, Austria4 aut
7001 a Burghuber, Ottou Ludwig Boltzmann Institute for Lung Health, Vienna, Austria; Faculty of Medicine, Sigmund Freud University, Vienna, Austria4 aut
7001 a Bolund, Anneli Cleau Dept of Public Health, Environment Occupation and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark4 aut
7001 a Custovic, Adnanu National Heart and Lung Institute, Imperial College London, London, United Kingdom4 aut
7001 a Devereux, Grahamu Liverpool School of Tropical Medicine, Liverpool, United Kingdom4 aut
7001 a Donaldson, Gavin C.u National Heart and Lung Institute, Imperial College London, London, United Kingdom4 aut
7001 a Duijts, Liesbethu The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands; Division of Respiratory Medicine and Allergology, and Neonatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands; Division of Neonatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands4 aut
7001 a Esplugues, Anau Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Nursing Department, Faculty of Nursing and Chiropody, Universitat de València, Valencia, Spain; Epidemiology and Environmental Health Joint Research Unit, FISABIO−Universitat Jaume I−Universitat de València, Valencia, Spain4 aut
7001 a Faner, Rosau Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain4 aut
7001 a Ballester, Ferranu Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Nursing Department, Faculty of Nursing and Chiropody, Universitat de València, Valencia, Spain; Epidemiology and Environmental Health Joint Research Unit, FISABIO−Universitat Jaume I−Universitat de València, Valencia, Spain4 aut
7001 a Garcia-Aymerich, Judithu ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain4 aut
7001 a Gehring, Ulrikeu Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands4 aut
7001 a Haider, Sadiau National Heart and Lung Institute, Imperial College London, London, United Kingdom4 aut
7001 a Hartl, Sylviau Ludwig Boltzmann Institute for Lung Health, Vienna, Austria; Faculty of Medicine, Sigmund Freud University, Vienna, Austria4 aut
7001 a Backman, Helenau Umeå universitet,Avdelningen för hållbar hälsa4 aut0 (Swepub:umu)heaban01
7001 a Holloway, John W.u NIHR Southampton Biomedical Research Centre, University Hospitals Southampton NHS Foundation Trust, Southampton, United Kingdom; Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom4 aut
7001 a Koppelman, Gerard H.u University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, University of Groningen, Groningen, Netherlands; Dept of Pediatric Pulmonology and Pediatric Allergology, University Medical Center Groningen, Beatrix Children’s Hospital, University of Groningen, Groningen, Netherlands4 aut
7001 a Lertxundi, Aitanau Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Dept of Preventive Medicine and Public Health, Faculty of Medicine, University of the Basque Country (UPV/EHU), Leioa, Spain; BIODONOSTIA Health Research Institute, Donostia-San Sebastian, Spain4 aut
7001 a Holmen, Turid Lingaasu Dept of Public Health and General Practice, HUNT Research Center, NTNU, Levanger, Norway4 aut
7001 a Lowe, Lesleyu Division of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester Academic Health Science Centre, NIHR, Manchester, United Kingdom; Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester, United Kingdom4 aut
7001 a Mensink-Bout, Sara M.u The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands4 aut
7001 a Murray, Clare S.u Division of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester Academic Health Science Centre, NIHR, Manchester, United Kingdom; Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester, United Kingdom4 aut
7001 a Roberts, Grahamu David Hide Asthma and Allergy Research Centre, Newport, United Kingdom; NIHR Southampton Biomedical Research Centre, University Hospitals Southampton NHS Foundation Trust, Southampton, United Kingdom; Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom4 aut
7001 a Hedman, Linnea,d 1979-u Umeå universitet,Avdelningen för hållbar hälsa4 aut0 (Swepub:umu)evli0029
7001 a Schlünssen, Viviu Dept of Public Health, Environment Occupation and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark4 aut
7001 a Sigsgaard, Torbenu Dept of Public Health, Environment Occupation and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark4 aut
7001 a Simpson, Angelau Division of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester Academic Health Science Centre, NIHR, Manchester, United Kingdom; Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester, United Kingdom4 aut
7001 a Sunyer, Jordiu ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain; IMIM-Parc Salut Mar, Barcelona, Spain4 aut
7001 a Torrent, Matiesu ib-salut, Area de Salut de Menorca, Menorca, Spain4 aut
7001 a Turner, Stephenu Royal Aberdeen Children’s Hospital NHS Grampian, Aberdeen, United Kingdom4 aut
7001 a Van den Berge, Maartenu University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, University of Groningen, Groningen, Netherlands; Dept of Pulmonary Diseases, University Medical Center Groningen, University of Groningen, Groningen, Netherlands4 aut
7001 a Vermeulen, Roel C.H.u Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands4 aut
7001 a Vikjord, Sigrid Anna Aalbergu Dept of Public Health and Nursing, Faculty of Medicine and Health Sciences, HUNT Research Centre, Norwegian University of Science and Technology (NTNU), Levanger, Norway; Dept of Medicine and Rehabilitation, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway4 aut
7001 a Wedzicha, Jadwiga A.u National Heart and Lung Institute, Imperial College London, London, United Kingdom4 aut
7001 a van der Zee, Anke H. Maitlandu Dept of Respiratory Medicine, Amsterdam University Medical Centers (UMC), University of Amsterdam, Amsterdam, Netherlands; Pediatric Respiratory Medicine, Emma Children’s Hospital, Amsterdam UMC, Amsterdam, Netherlands4 aut
7001 a Melén, Eriku Karolinska Institutet4 aut
7102 a Karolinska Institutetb MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom4 org
7730 t ERJ Open Researchd : ERS Publicationsg 7:4q 7:4x 2312-0541
8564 u https://doi.org/10.1183/23120541.00457-2021y Fulltext
8564 u https://umu.diva-portal.org/smash/get/diva2:1626260/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://openres.ersjournals.com/content/erjor/early/2021/09/09/23120541.00457-2021.full.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-191192
8564 8u https://doi.org/10.1183/23120541.00457-2021
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:149174473

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