Sökning: onr:"swepub:oai:DiVA.org:uu-177573" > Baseline NT-proBNP ...
Fältnamn | Indikatorer | Metadata |
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000 | 03796naa a2200481 4500 | |
001 | oai:DiVA.org:uu-177573 | |
003 | SwePub | |
008 | 120716s2012 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1775732 URI |
024 | 7 | a https://doi.org/10.1007/s11239-012-0691-02 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a van Diepen, Sean4 aut |
245 | 1 0 | a Baseline NT-proBNP and biomarkers of inflammation and necrosis in patients with ST-segment elevation myocardial infarction :b insights from the APEX-AMI trial |
264 | c 2012-02-04 | |
264 | 1 | b Springer Science and Business Media LLC,c 2012 |
338 | a print2 rdacarrier | |
520 | a Coronary plaque rupture is associated with a systemic inflammatory response. The relationship between baseline N-terminal pro B-type natriuretic peptide (NT-proBNP), a prognostic marker in patients with acute coronary syndromes, and systemic inflammatory mediators in patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI) is not well described. Of 5,745 STEMI patients treated with primary PCI in the APEX-AMI trial, we evaluated the relationship between baseline NT-proBNP levels and baseline levels of inflammatory markers and markers of myonecrosis in a subset of 772 who were enrolled in a biomarker substudy. Spearman correlations (r (s)) were calculated between baseline NT-proBNP levels and a panel of ten systemic inflammatory biomarkers. Interleukin (IL)-6, a pro-inflammatory cytokine, was significantly positively correlated with NT-proBNP (r (s) = 0.317, P < 0.001). In a sensitivity analysis excluding all heart failure patients, the correlation between baseline IL-6 and NT-proBNP remained significant (n = 651, r (s) = 0.296, P < 0.001). A positive association was also observed with high sensitivity C-reactive protein (r (s) = 0.377, P < 0.001) and there was a weak negative correlation with the anti-inflammatory cytokine IL-10 (r (s) = -0.109, P = 0.003). No other significant correlations were observed among the other testes inflammatory cytokines and chemokines. In STEMI patients undergoing primary PCI, the pro-inflammatory cytokine IL-6 was modestly correlated with baseline NT-proBNP levels. This relationship remained significant in patients without heart failure. This finding is consistent with pre-clinical and clinical research suggesting that systemic inflammation may influence NT-proBNP expression independently of myocardial stretch. | |
653 | a N-terminal pro-brain natriuretic peptide | |
653 | a Interleukin-6 | |
653 | a Interleukin-10 | |
653 | a C-reactive protein | |
700 | 1 | a Roe, Matthew T.4 aut |
700 | 1 | a Lopes, Renato D.4 aut |
700 | 1 | a Stebbins, Amanda4 aut |
700 | 1 | a James, Stefanu Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),kardiologi4 aut0 (Swepub:uu)stjam367 |
700 | 1 | a Newby, L. Kristin4 aut |
700 | 1 | a Moliterno, David J.4 aut |
700 | 1 | a Neumann, Franz-Josef4 aut |
700 | 1 | a Ezekowitz, Justin A.4 aut |
700 | 1 | a Mahaffey, Kenneth W.4 aut |
700 | 1 | a Hochman, Judith S.4 aut |
700 | 1 | a Hamm, Christian W.4 aut |
700 | 1 | a Armstrong, Paul W.4 aut |
700 | 1 | a Theroux, Pierre4 aut |
700 | 1 | a Granger, Christopher B.4 aut |
710 | 2 | a Uppsala universitetb Uppsala kliniska forskningscentrum (UCR)4 org |
773 | 0 | t Journal of Thrombosis and Thrombolysisd : Springer Science and Business Media LLCg 34:1, s. 106-113q 34:1<106-113x 0929-5305x 1573-742X |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-177573 |
856 | 4 8 | u https://doi.org/10.1007/s11239-012-0691-0 |
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