SwePub
Tyck till om SwePub Sök här!
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:DiVA.org:uu-177573"
 

Sökning: onr:"swepub:oai:DiVA.org:uu-177573" > Baseline NT-proBNP ...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003796naa a2200481 4500
001oai:DiVA.org:uu-177573
003SwePub
008120716s2012 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1775732 URI
0247 a https://doi.org/10.1007/s11239-012-0691-02 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a van Diepen, Sean4 aut
2451 0a Baseline NT-proBNP and biomarkers of inflammation and necrosis in patients with ST-segment elevation myocardial infarction :b insights from the APEX-AMI trial
264 c 2012-02-04
264 1b Springer Science and Business Media LLC,c 2012
338 a print2 rdacarrier
520 a Coronary plaque rupture is associated with a systemic inflammatory response. The relationship between baseline N-terminal pro B-type natriuretic peptide (NT-proBNP), a prognostic marker in patients with acute coronary syndromes, and systemic inflammatory mediators in patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI) is not well described. Of 5,745 STEMI patients treated with primary PCI in the APEX-AMI trial, we evaluated the relationship between baseline NT-proBNP levels and baseline levels of inflammatory markers and markers of myonecrosis in a subset of 772 who were enrolled in a biomarker substudy. Spearman correlations (r (s)) were calculated between baseline NT-proBNP levels and a panel of ten systemic inflammatory biomarkers. Interleukin (IL)-6, a pro-inflammatory cytokine, was significantly positively correlated with NT-proBNP (r (s) = 0.317, P < 0.001). In a sensitivity analysis excluding all heart failure patients, the correlation between baseline IL-6 and NT-proBNP remained significant (n = 651, r (s) = 0.296, P < 0.001). A positive association was also observed with high sensitivity C-reactive protein (r (s) = 0.377, P < 0.001) and there was a weak negative correlation with the anti-inflammatory cytokine IL-10 (r (s) = -0.109, P = 0.003). No other significant correlations were observed among the other testes inflammatory cytokines and chemokines. In STEMI patients undergoing primary PCI, the pro-inflammatory cytokine IL-6 was modestly correlated with baseline NT-proBNP levels. This relationship remained significant in patients without heart failure. This finding is consistent with pre-clinical and clinical research suggesting that systemic inflammation may influence NT-proBNP expression independently of myocardial stretch.
653 a N-terminal pro-brain natriuretic peptide
653 a Interleukin-6
653 a Interleukin-10
653 a C-reactive protein
7001 a Roe, Matthew T.4 aut
7001 a Lopes, Renato D.4 aut
7001 a Stebbins, Amanda4 aut
7001 a James, Stefanu Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),kardiologi4 aut0 (Swepub:uu)stjam367
7001 a Newby, L. Kristin4 aut
7001 a Moliterno, David J.4 aut
7001 a Neumann, Franz-Josef4 aut
7001 a Ezekowitz, Justin A.4 aut
7001 a Mahaffey, Kenneth W.4 aut
7001 a Hochman, Judith S.4 aut
7001 a Hamm, Christian W.4 aut
7001 a Armstrong, Paul W.4 aut
7001 a Theroux, Pierre4 aut
7001 a Granger, Christopher B.4 aut
7102 a Uppsala universitetb Uppsala kliniska forskningscentrum (UCR)4 org
7730 t Journal of Thrombosis and Thrombolysisd : Springer Science and Business Media LLCg 34:1, s. 106-113q 34:1<106-113x 0929-5305x 1573-742X
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-177573
8564 8u https://doi.org/10.1007/s11239-012-0691-0

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy