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Sökning: onr:"swepub:oai:lup.lub.lu.se:32597876-d603-45d2-bbe4-3d725d06d78e" > Pre- and Postnatal ...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003993naa a2200373 4500
001oai:lup.lub.lu.se:32597876-d603-45d2-bbe4-3d725d06d78e
003SwePub
008211213s2022 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/32597876-d603-45d2-bbe4-3d725d06d78e2 URI
0247 a https://doi.org/10.1007/s40262-021-01076-02 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Wu, Yunjiao4 aut
2451 0a Pre- and Postnatal Maturation are Important for Fentanyl Exposure in Preterm and Term Newborns : A Pooled Population Pharmacokinetic Study
264 c 2021-11-13
264 1b Springer Science and Business Media LLC,c 2022
520 a Background and Objective: Fentanyl is an opioid commonly used to prevent and treat severe pain in neonates; however, its use is off label and mostly based on bodyweight. Given the limited pharmacokinetic information across the entire neonatal age range, we characterized the pharmacokinetics of fentanyl across preterm and term neonates to individualize dosing. Methods: We pooled data from two previous studies on 164 newborns with a median gestational age of 29.0 weeks (range 23.9–42.3), birthweight of 1055 g (range 390–4245), and postnatal age (PNA) of 1 day (range 0–68). In total, 673 plasma samples upon bolus dosing (69 patients; median dose 2.1 μg/kg, median 2 boluses per patient) or continuous infusions (95 patients; median dose 1.1 μg/kg/h for 30 h) with and without boluses were used for population pharmacokinetic modeling in NONMEM® 7.4. Results: Clearance in neonates with birthweight of 2000 and 3000 g was 2.8- and 5.0-fold the clearance in a neonate with birthweight of 1000 g, respectively. Fentanyl clearance at PNA of 7, 14, and 21 days was 2.7-fold, 3.8-fold, and 4.6-fold the clearance at 1 day, respectively. Bodyweight-based dosing resulted in large differences in fentanyl concentrations. Depending on PNA and birthweight, fentanyl concentrations increased slowly after the start of therapy for both intermittent boluses and continuous infusion and reached a maximum concentration at 12–48 h. Conclusions: As both prenatal and postnatal maturation are important for fentanyl exposure, we propose a birthweight- and PNA-based dosage regimen. To provide rapid analgesia in the first 24 h of treatment, additional loading doses need to be considered.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmaceutiska vetenskaper0 (SwePub)301012 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmaceutical Sciences0 (SwePub)301012 hsv//eng
7001 a Völler, Swantjeu Sophia Children's Hospital4 aut
7001 a Flint, Robert B.u Erasmus University Medical Center,Sophia Children's Hospital4 aut
7001 a Simons, Sinno H.P.u Sophia Children's Hospital4 aut
7001 a Allegaert, Karelu Erasmus University Medical Center,Catholic University of Leuven4 aut
7001 a Fellman, Vinetau Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,University of Helsinki,Folkhälsan Research Center4 aut0 (Swepub:lu)pedi-vfe
7001 a Knibbe, Catherijne A.J.u Sophia Children's Hospital,St. Antonius Hospital4 aut
7102 a Sophia Children's Hospitalb Erasmus University Medical Center4 org
7730 t Clinical Pharmacokineticsd : Springer Science and Business Media LLCg 61:3, s. 401-412q 61:3<401-412x 0312-5963x 1179-1926
8564 u http://dx.doi.org/10.1007/s40262-021-01076-0x freey FULLTEXT
8564 u https://link.springer.com/content/pdf/10.1007/s40262-021-01076-0.pdf
8564 8u https://lup.lub.lu.se/record/32597876-d603-45d2-bbe4-3d725d06d78e
8564 8u https://doi.org/10.1007/s40262-021-01076-0

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