Sökning: onr:"swepub:oai:lup.lub.lu.se:67190f37-9d28-4232-9d9f-4966a35d83cd" > Population-Based St...
Fältnamn | Indikatorer | Metadata |
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000 | 04200naa a2200493 4500 | |
001 | oai:lup.lub.lu.se:67190f37-9d28-4232-9d9f-4966a35d83cd | |
003 | SwePub | |
008 | 160404s2010 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/15955682 URI |
024 | 7 | a https://doi.org/10.1200/JCO.2009.24.24952 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Malone, Kathleen E4 aut |
245 | 1 0 | a Population-Based Study of the Risk of Second Primary Contralateral Breast Cancer Associated With Carrying a Mutation in BRCA1 or BRCA2. |
264 | 1 | c 2010 |
520 | a PURPOSE: Women with breast cancer diagnosed early in life comprise a substantial portion of those tested for BRCA1/BRCA2 mutations; however, little information is available on the subsequent risks of contralateral breast cancer in mutation carriers. This study assessed the risk of subsequent contralateral breast cancer associated with carrying a BRCA1 or BRCA2 mutation. PATIENTS AND METHODS: In this nested case-control study, patients with contralateral breast cancer diagnosed 1 year or more after a first primary breast cancer (n = 705) and controls with unilateral breast cancer (n = 1,398) were ascertained from an underlying population-based cohort of 52,536 women diagnosed with a first invasive breast cancer before age 55 years. Interviews and medical record reviews were used to collect risk factor and treatment histories. All women were tested for BRCA1/BRCA2 mutations. Relative (rate ratios) and absolute (5- and 10-year cumulative) risks of developing contralateral breast cancer following a first invasive breast cancer were computed. RESULTS: Compared with noncarriers, BRCA1 and BRCA2 mutation carriers had 4.5-fold (95% CI, 2.8- to 7.1-fold) and 3.4-fold (95% CI, 2.0- to 5.8-fold) increased risks of contralateral breast cancer, respectively. The relative risk of contralateral breast cancer for BRCA1 mutation carriers increased as age of first diagnosis decreased. Age-specific cumulative risks are provided for clinical guidance. CONCLUSION: The risks of subsequent contralateral breast cancer are substantial for women who carry a BRCA1/BRCA2 mutation. These findings have important clinical relevance regarding the assessment of BRCA1/BRCA2 status in patients with breast cancer and the counseling and clinical management of patients found to carry a mutation. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
700 | 1 | a Begg, Colin B4 aut |
700 | 1 | a Haile, Robert W4 aut |
700 | 1 | a Borg, Åkeu Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)onk-abo |
700 | 1 | a Concannon, Patrick4 aut |
700 | 1 | a Tellhed, Linau Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)onk-ljo |
700 | 1 | a Xue, Shanyan4 aut |
700 | 1 | a Teraoka, Sharon4 aut |
700 | 1 | a Bernstein, Leslie4 aut |
700 | 1 | a Capanu, Marinela4 aut |
700 | 1 | a Reiner, Anne S4 aut |
700 | 1 | a Riedel, Elyn R4 aut |
700 | 1 | a Thomas, Duncan C4 aut |
700 | 1 | a Mellemkjær, Lene4 aut |
700 | 1 | a Lynch, Charles F4 aut |
700 | 1 | a Boice, John D4 aut |
700 | 1 | a Anton-Culver, Hoda4 aut |
700 | 1 | a Bernstein, Jonine L4 aut |
710 | 2 | a Bröstcancer-genetikb Sektion I4 org |
773 | 0 | t Journal of Clinical Oncologyg 28, s. 2404-2410q 28<2404-2410x 1527-7755 |
856 | 4 | u http://www.ncbi.nlm.nih.gov/pubmed/20368571?dopt=Abstracty FULLTEXT |
856 | 4 | u http://dx.doi.org/10.1200/JCO.2009.24.2495y FULLTEXT |
856 | 4 8 | u https://lup.lub.lu.se/record/1595568 |
856 | 4 8 | u https://doi.org/10.1200/JCO.2009.24.2495 |
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