Sökning: onr:"swepub:oai:lup.lub.lu.se:67c09f43-d68f-4df3-b04c-4cb0279a3314" > The T-381C SNP in B...
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000 | 03845naa a2200613 4500 | |
001 | oai:lup.lub.lu.se:67c09f43-d68f-4df3-b04c-4cb0279a3314 | |
003 | SwePub | |
008 | 160401s2009 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/14420722 URI |
024 | 7 | a https://doi.org/10.1093/hmg/ddp1692 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Choquet, Helene4 aut |
245 | 1 0 | a The T-381C SNP in BNP gene may be modestly associated with type 2 diabetes: an updated meta-analysis in 49 279 subjects |
264 | c 2009-04-18 | |
264 | 1 | b Oxford University Press (OUP),c 2009 |
520 | a A recent study reported an association between the brain natriuretic peptide (BNP) promoter T-381C polymorphism (rs198389) and protection against type 2 diabetes (T2D). As replication in several studies is mandatory to confirm genetic results, we analyzed the T-381C polymorphism in seven independent case-control cohorts and in 291 T2D-enriched pedigrees totalling 39 557 subjects of European origin. A meta-analysis of the seven case-control studies (n = 39 040) showed a nominal protective effect [odds ratio (OR) = 0.86 (0.79-0.94), P = 0.0006] of the CC genotype on T2D risk, consistent with the previous study. By combining all available data (n = 49 279), we further confirmed a modest contribution of the BNP T-381C polymorphism for protection against T2D [OR = 0.86 (0.80-0.92), P = 1.4 x 10(-5)]. Potential confounders such as gender, age, obesity status or family history were tested in 4335 T2D and 4179 normoglycemic subjects and they had no influence on T2D risk. This study provides further evidence of a modest contribution of the BNP T-381C polymorphism in protection against T2D and illustrates the difficulty of unambiguously proving modest-sized associations even with large sample sizes. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
700 | 1 | a Cavalcanti-Proenca, Christine4 aut |
700 | 1 | a Lecoeur, Cecile4 aut |
700 | 1 | a Dina, Christian4 aut |
700 | 1 | a Cauchi, Stephane4 aut |
700 | 1 | a Vaxillaire, Martine4 aut |
700 | 1 | a Hadjadj, Samy4 aut |
700 | 1 | a Horber, Fritz4 aut |
700 | 1 | a Potoczna, Natasha4 aut |
700 | 1 | a Charpentier, Guillaume4 aut |
700 | 1 | a Ruiz, Juan4 aut |
700 | 1 | a Hercberg, Serge4 aut |
700 | 1 | a Maimaitiming, Suliya4 aut |
700 | 1 | a Roussel, Ronan4 aut |
700 | 1 | a Boenhnke, Michael4 aut |
700 | 1 | a Jackson, Anne U.4 aut |
700 | 1 | a Patsch, Wolfgang4 aut |
700 | 1 | a Krempler, Franz4 aut |
700 | 1 | a Voight, Benjamin F.4 aut |
700 | 1 | a Altshuler, David4 aut |
700 | 1 | a Groop, Leifu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-lgr |
700 | 1 | a Thorleifsson, Gudmar4 aut |
700 | 1 | a Steinthorsdottir, Valgerdur4 aut |
700 | 1 | a Stefansson, Kari4 aut |
700 | 1 | a Balkau, Beverley4 aut |
700 | 1 | a Froguel, Philippe4 aut |
700 | 1 | a Meyre, David4 aut |
710 | 2 | a Genomik, diabetes och endokrinologib Forskargrupper vid Lunds universitet4 org |
773 | 0 | t Human Molecular Geneticsd : Oxford University Press (OUP)g 18:13, s. 2495-2501q 18:13<2495-2501x 0964-6906x 1460-2083 |
856 | 4 | u http://dx.doi.org/10.1093/hmg/ddp169y FULLTEXT |
856 | 4 | u https://academic.oup.com/hmg/article-pdf/18/13/2495/17246549/ddp169.pdf |
856 | 4 8 | u https://lup.lub.lu.se/record/1442072 |
856 | 4 8 | u https://doi.org/10.1093/hmg/ddp169 |
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