Sökning: onr:"swepub:oai:lup.lub.lu.se:98dd8cd9-724d-4011-88c3-190f2295781b" > Streptokinase activ...
Fältnamn | Indikatorer | Metadata |
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000 | 04089naa a2200361 4500 | |
001 | oai:lup.lub.lu.se:98dd8cd9-724d-4011-88c3-190f2295781b | |
003 | SwePub | |
008 | 160401s1994 | |||||||||||000 ||eng| | |
009 | oai:lup.lub.lu.se:3ff84f2f-6d00-4ea4-93a6-c4143ac1f165 | |
024 | 7 | a https://lup.lub.lu.se/record/310972 URI |
024 | 7 | a https://lup.lub.lu.se/record/12166062 URI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Ben Nasr, Abdelhakim4 aut |
245 | 1 0 | a Streptokinase activates plasminogen bound to human group C and group G streptococci through M-like proteins |
264 | 1 | c 1994 |
520 | a An ability to interact with plasminogen or plasmin could provide micro-organisms with a mechanism for invasion. Thus, group A, C and G streptococci secrete streptokinase which binds and activates plasminogen. Some streptococci also express surface structures which bind plasminogen without causing its activation. Plasminogen-binding surface proteins were extracted from one group C and one group G streptococcal isolate. Both proteins were found to bind plasmin, fibrinogen and serum albumin in addition to plasminogen. Gene fragments encoding the streptococcal proteins were amplified by PCR and were subsequently cloned and expressed in Escherichia coli. DNA sequence determination revealed for both genes open reading frames encoding proteins which contained repetitive domains and a carboxyl-terminal unrepeated region that were typical of M and M-like proteins. Though the amino-terminal regions of the group C and G streptococcal proteins demonstrated a rather high overall similarity between themselves, they were not similar to the variable regions of other M-like proteins with one exception: there was a 46% identity between the first 22 amino acids of the group G streptococcal protein and the corresponding sequence of PAM, the plasminogen-binding M-like protein of type M53 group A streptococci. Like the proteins extracted from the streptococci, the recombinant proteins bound plasminogen, fibrinogen and albumin. The three plasma proteins bound to separate sites on the streptococcal M-like proteins. Plasminogen bound by the group C and G streptococcal proteins was readily activated by streptokinase, providing evidence for a functional link between the secreted plasminogen-activator and proteins exposed on the bacterial surface. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Mikrobiologi inom det medicinska området0 (SwePub)301092 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Microbiology in the medical area0 (SwePub)301092 hsv//eng |
700 | 1 | a Wistedt, Annika4 aut |
700 | 1 | a Ringdahl, Ulrikau Lund University,Lunds universitet,Institutionen för immunteknologi,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Immunotechnology,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)mmb-uri |
700 | 1 | a Sjöbring, Ulfu Lund University,Lunds universitet,Avdelningen för mikrobiologi, immunologi och glykobiologi - MIG,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Microbiology, Immunology and Glycobiology - MIG,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)mmb-usj |
710 | 2 | a Institutionen för immunteknologib Institutioner vid LTH4 org |
773 | 0 | t European Journal of Biochemistryg 222:2, s. 76-267q 222:2<76-267x 0014-2956 |
856 | 4 | u http://www.ncbi.nlm.nih.gov/pubmed/8020466x freey FULLTEXT |
856 | 4 | u http://onlinelibrary.wiley.com/doi/10.1111/j.1432-1033.1994.tb18865.x/abstractx freey FULLTEXT |
856 | 4 8 | u https://lup.lub.lu.se/record/31097 |
856 | 4 8 | u https://lup.lub.lu.se/record/1216606 |
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