Inflammation-sensitive plasma proteins, diabetes, and mortality and incidence of myocardial infarction and stroke: a population-based study.

• This study explores the relationship of inflammation-sensitive plasma proteins (ISPs) with the prevalence of diabetes and the interrelationships between ISPs and diabetes in the prediction of death and incidence of myocardial infarction and stroke. Plasma levels of fibrinogen, α1-antitrypsin, haptoglobin, ceruloplasmin, and orosomucoid were assessed in 6,050 men, aged 28–61 years. All-cause and cardiovascular mortality and incidence of myocardial infarction and stroke were monitored over 18.7 ± 3.7 years. Prevalence of diabetes (n = 321) was significantly associated with ISP levels among overweight and obese men but not among men with BMI <25 kg/m2. The association was similar for insulin resistance according to homeostasis model assessment. High ISP levels (two or more ISPs in the top quartile) increased the cardiovascular risk among diabetic men. The risk factor-adjusted relative risks for cardiovascular mortality, myocardial infarction, and stroke were 2.8 (CI 1.8–4.5), 2.2 (1.5–3.2), and 2.5 (1.4–4.6), respectively, for diabetic men with high ISP levels (reference: nondiabetic men with low ISP levels). The corresponding risks for diabetic men with low ISP levels were 1.8 (1.1–3.0), 1.3 (0.8–2.1), and 1.2 (0.6–2.5), respectively. In conclusion, in this population-based cohort, diabetes was associated with increased ISP levels among overweight and obese men but not among men with normal weight. High ISP levels increased the cardiovascular risk similarly in diabetic as compared with nondiabetic men.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

Keyword

Incidence

Human

Heart Diseases: mortality

Heart Diseases: epidemiology

Diabetes Mellitus: complications

Creatinine: blood

Cohort Studies

Cholesterol: blood

Cerebrovascular Accident: mortality

Cerebrovascular Accident: epidemiology

Cause of Death

Cardiovascular Diseases: mortality

Cardiovascular Diseases: epidemiology

Body Mass Index

Blood Proteins: physiology

Diabetes Mellitus: epidemiology

Blood Pressure

Inflammation: blood

Male

Middle Age

Myocardial Infarction: epidemiology

Myocardial Infarction: mortality

Prevalence

Risk Factors

Smoking: physiopathology

Support

Non-U.S. Gov't

Sweden: epidemiology

Triglycerides: blood

Publication and Content Type

art (subject category)

ref (subject category)