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High risk of tobacco-related cancers in CDKN2A mutation-positive melanoma families.
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- Helgadottir, Hildur (author)
- Karolinska Institutet
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- Höiom, Veronica (author)
- Karolinska Institutet
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- Jönsson, Göran B (author)
- Karolinska Institutet,Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Hansson, Johan (author)
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- (creator_code:org_t)
- 2014-06-16
- 2014
- English 8 s.
- In: Journal of Medical Genetics. - : BMJ. - 0022-2593 .- 1468-6244. ; 51:8, s. 545-552
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Germline mutations in the tumour suppressor gene CDKN2A occur in 5-20% of familial melanoma cases. A single founder mutation, p.Arg112dup, accounts for the majority of CDKN2A mutations in Swedish carriers. In a national program, carriers of p.Arg112dup mutation have been identified. The aim of this study was to assess cancer risks in p.Arg112dup carriers and their first degree relatives (FDRs) and second degree relatives (SDRs).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
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- ref (subject category)
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- Höiom, Veronica
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- Olsson, Håkan
- Hansson, Johan
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