Search: L773:0028 4793 OR L773:1533 4406 >
Apixaban with Antip...
Apixaban with Antiplatelet Therapy after Acute Coronary Syndrome
-
Alexander, John H. (author)
-
Lopes, Renato D. (author)
-
- James, Stefan (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)
-
show more...
-
Kilaru, Rakhi (author)
-
He, Yaohua (author)
-
Mohan, Puneet (author)
-
Bhatt, Deepak L. (author)
-
Goodman, Shaun (author)
-
Verheugt, Freek W. (author)
-
Flather, Marcus (author)
-
Huber, Kurt (author)
-
Liaw, Danny (author)
-
Husted, Steen E. (author)
-
Lopez-Sendon, Jose (author)
-
De Caterina, Raffaele (author)
-
Jansky, Petr (author)
-
Darius, Harald (author)
-
Vinereanu, Dragos (author)
-
Cornel, Jan H. (author)
-
Cools, Frank (author)
-
Atar, Dan (author)
-
Luis Leiva-Pons, Jose (author)
-
Keltai, Matyas (author)
-
Ogawa, Hisao (author)
-
Pais, Prem (author)
-
Parkhomenko, Alexander (author)
-
Ruzyllo, Witold (author)
-
Diaz, Rafael (author)
-
White, Harvey (author)
-
Ruda, Mikhail (author)
-
Geraldes, Margarida (author)
-
Lawrence, Jack (author)
-
Harrington, Robert A. (author)
-
- Wallentin, Lars (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)
-
show less...
-
(creator_code:org_t)
- 2011
- 2011
- English.
-
In: New England Journal of Medicine. - 0028-4793 .- 1533-4406. ; 365:8, s. 699-708
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Background: Apixaban, an oral, direct factor Xa inhibitor, may reduce the risk of recurrent ischemic events when added to antiplatelet therapy after an acute coronary syndrome.Methods: We conducted a randomized, double-blind, placebo-controlled clinical trial comparing apixaban, at a dose of 5 mg twice daily, with placebo, in addition to standard antiplatelet therapy, in patients with a recent acute coronary syndrome and at least two additional risk factors for recurrent ischemic events.Results: The trial was terminated prematurely after recruitment of 7392 patients because of an increase in major bleeding events with apixaban in the absence of a counterbalancing reduction in recurrent ischemic events. With a median follow-up of 241 days, the primary outcome of cardiovascular death, myocardial infarction, or ischemic stroke occurred in 279 of the 3705 patients (7.5%) assigned to apixaban (13.2 events per 100 patient-years) and in 293 of the 3687 patients (7.9%) assigned to placebo (14.0 events per 100 patient-years) (hazard ratio with apixaban, 0.95; 95% confidence interval [CI], 0.80 to 1.11; P = 0.51). The primary safety outcome of major bleeding according to the Thrombolysis in Myocardial Infarction (TIMI) definition occurred in 46 of the 3673 patients (1.3%) who received at least one dose of apixaban (2.4 events per 100 patient-years) and in 18 of the 3642 patients (0.5%) who received at least one dose of placebo (0.9 events per 100 patient-years) (hazard ratio with apixaban, 2.59; 95% CI, 1.50 to 4.46; P = 0.001). A greater number of intracranial and fatal bleeding events occurred with apixaban than with placebo.Conclusions: The addition of apixaban, at a dose of 5 mg twice daily, to antiplatelet therapy in high-risk patients after an acute coronary syndrome increased the number of major bleeding events without a significant reduction in recurrent ischemic events.
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Alexander, John ...
-
Lopes, Renato D.
-
James, Stefan
-
Kilaru, Rakhi
-
He, Yaohua
-
Mohan, Puneet
-
show more...
-
Bhatt, Deepak L.
-
Goodman, Shaun
-
Verheugt, Freek ...
-
Flather, Marcus
-
Huber, Kurt
-
Liaw, Danny
-
Husted, Steen E.
-
Lopez-Sendon, Jo ...
-
De Caterina, Raf ...
-
Jansky, Petr
-
Darius, Harald
-
Vinereanu, Drago ...
-
Cornel, Jan H.
-
Cools, Frank
-
Atar, Dan
-
Luis Leiva-Pons, ...
-
Keltai, Matyas
-
Ogawa, Hisao
-
Pais, Prem
-
Parkhomenko, Ale ...
-
Ruzyllo, Witold
-
Diaz, Rafael
-
White, Harvey
-
Ruda, Mikhail
-
Geraldes, Margar ...
-
Lawrence, Jack
-
Harrington, Robe ...
-
Wallentin, Lars
-
show less...
- Articles in the publication
-
New England Jour ...
- By the university
-
Uppsala University