Tyck till om SwePub Sök
här!
Sökning: onr:"swepub:oai:openarchive.ki.se:10616/46149" >
A total-population ...
A total-population multigenerational family clustering study of autoimmune diseases in obsessive-compulsive disorder and Tourette’s/chronic tic disorders
-
- Mataix-Cols, David (författare)
- Karolinska Institutet
-
- Frans, Emma (författare)
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
-
- Pérez-Vigil, Ana (författare)
- Karolinska Institutet
-
visa fler...
-
- Kuja-Halkola, Ralf (författare)
- Karolinska Institutet
-
- Gromark, Caroline (författare)
- Karolinska Institutet
-
- Isomura, Kayoko (författare)
- Karolinska Institutet
-
- Fernández de la Cruz, Lorena (författare)
- Karolinska Institutet
-
- Serlachius, Eva (författare)
- Karolinska Institutet
-
- Leckman, James F (författare)
- Child Study Center, Yale University School of Medicine, New Haven CT, USA
-
- Crowley, James J (författare)
- Karolinska Institutet
-
- Rück, Christian (författare)
- Karolinska Institutet
-
- Almqvist, Catarina (författare)
- Karolinska Institutet
-
- Lichtenstein, Paul (författare)
- Karolinska Institutet
-
- Larsson, Henrik, 1975- (författare)
- Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
-
visa färre...
-
(creator_code:org_t)
-
-
visa fler...
-
-
visa färre...
- ISSN 1359-4184
- 2017-11-14
- 2017
- Engelska.
-
Ingår i: Molecular Psychiatry. - Stockholm : Karolinska Institutet, Dept of Medical Epidemiology and Biostatistics. - 1359-4184 .- 1476-5578.
- Relaterad länk:
-
http://hdl.handle.ne... (primary) (Object in context) (free)
-
visa fler...
-
https://europepmc.or...
-
http://hdl.handle.ne...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- The association between obsessive-compulsive disorder (OCD) and Tourette's/chronic tic disorders (TD/CTD) with autoimmune diseases (ADs) is uncertain. In this nationwide study, we sought to clarify the patterns of comorbidity and familial clustering of a broad range of ADs in individuals with OCD, individuals with TD/CTD and their biological relatives. From a birth cohort of 7 465 455 individuals born in Sweden between 1940 and 2007, we identified 30 082 OCD and 7279 TD/CTD cases in the National Patient Register and followed them up to 31 December 2013. The risk of 40 ADs was evaluated in individuals with OCD, individuals with TD/CTD and their first- (siblings, mothers, fathers), second- (half siblings) and third-degree (cousins) relatives, compared with population controls. Individuals with OCD and TD/CTD had increased comorbidity with any AD (43% and 36%, respectively) and many individual ADs. The risk of any AD and several individual ADs was consistently higher among first-degree relatives than among second- and third-degree relatives of OCD and TD/CTD probands. The risk of ADs was very similar in mothers, fathers and siblings of OCD probands, whereas it tended to be higher in mothers and fathers of TD/CTD probands (compared with siblings). The results suggest a familial link between ADs in general (that is, not limited to Streptococcus-related conditions) and both OCD and TD/CTD. Additional mother-specific factors, such as the placental transmission of antibodies, cannot be fully ruled out, particularly in TD/CTD.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Mataix-Cols, Dav ...
-
Frans, Emma
-
Pérez-Vigil, Ana
-
Kuja-Halkola, Ra ...
-
Gromark, Carolin ...
-
Isomura, Kayoko
-
visa fler...
-
Fernández de la ...
-
Serlachius, Eva
-
Leckman, James F
-
Crowley, James J
-
Rück, Christian
-
Almqvist, Catari ...
-
Lichtenstein, Pa ...
-
Larsson, Henrik, ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Psykiatri
- Artiklar i publikationen
-
Molecular Psychi ...
- Av lärosätet
-
Karolinska Institutet
-
Örebro universitet