Sökning: L773:1359 4184 OR L773:1476 5578 >
SARS-CoV-2 promotes...
SARS-CoV-2 promotes microglial synapse elimination in human brain organoids
-
, amudyata (författare)
-
Oliveira, AO (författare)
-
Malwade, S (författare)
-
visa fler...
-
- de Sousa, NR (författare)
- Karolinska Institutet
-
Goparaju, SK (författare)
-
Gracias, J (författare)
-
- Orhan, F (författare)
- Karolinska Institutet
-
- Steponaviciute, L (författare)
- Karolinska Institutet
-
- Schalling, M (författare)
- Karolinska Institutet
-
Sheridan, SD (författare)
-
Perlis, RH (författare)
-
- Rothfuchs, AG (författare)
- Karolinska Institutet
-
- Sellgren, CM (författare)
- Karolinska Institutet
-
visa färre...
-
(creator_code:org_t)
- 2022-10-05
- 2022
- Engelska.
-
Ingår i: Molecular psychiatry. - : Springer Science and Business Media LLC. - 1476-5578 .- 1359-4184. ; 2827:210, s. 3939-3950
- Relaterad länk:
-
http://kipublication...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Neuropsychiatric manifestations are common in both the acute and post-acute phase of SARS-CoV-2 infection, but the mechanisms of these effects are unknown. In a newly established brain organoid model with innately developing microglia, we demonstrate that SARS-CoV-2 infection initiate neuronal cell death and cause a loss of post-synaptic termini. Despite limited neurotropism and a decelerating viral replication, we observe a threefold increase in microglial engulfment of postsynaptic termini after SARS-CoV-2 exposure. We define the microglial responses to SARS-CoV-2 infection by single cell transcriptomic profiling and observe an upregulation of interferon-responsive genes as well as genes promoting migration and synapse engulfment. To a large extent, SARS-CoV-2 exposed microglia adopt a transcriptomic profile overlapping with neurodegenerative disorders that display an early synapse loss as well as an increased incident risk after a SARS-CoV-2 infection. Our results reveal that brain organoids infected with SARS-CoV-2 display disruption in circuit integrity via microglia-mediated synapse elimination and identifies a potential novel mechanism contributing to cognitive impairments in patients recovering from COVID-19.
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
, amudyata
-
Oliveira, AO
-
Malwade, S
-
de Sousa, NR
-
Goparaju, SK
-
Gracias, J
-
visa fler...
-
Orhan, F
-
Steponaviciute, ...
-
Schalling, M
-
Sheridan, SD
-
Perlis, RH
-
Rothfuchs, AG
-
Sellgren, CM
-
visa färre...
- Artiklar i publikationen
-
Molecular psychi ...
- Av lärosätet
-
Karolinska Institutet