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EuroInf 2 : Subthal...
EuroInf 2 : Subthalamic stimulation, apomorphine, and levodopa infusion in Parkinson's disease
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- Dafsari, Haidar S. (author)
- King's College Hospital,University Hospital of Cologne
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- Martinez-Martin, Pablo (author)
- Carlos III Health Institute
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- Rizos, Alexandra (author)
- King's College Hospital
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- Trost, Maja (author)
- University Medical Centre Ljubljana
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- dos Santos Ghilardi, Maria Gabriela (author)
- University of São Paulo
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- Reddy, Prashanth (author)
- King's College Hospital
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- Sauerbier, Anna (author)
- King's College London,King's College Hospital
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- Petry-Schmelzer, Jan Niklas (author)
- University Hospital of Cologne
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- Kramberger, Milica (author)
- University Medical Centre Ljubljana
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- Borgemeester, Robbert W.K. (author)
- University Medical Center Groningen,University of Groningen
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- Barbe, Michael T. (author)
- University Hospital of Cologne
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- Ashkan, Keyoumars (author)
- King's College Hospital
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- Silverdale, Monty (author)
- University of Manchester
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- Evans, Julian (author)
- University of Manchester
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- Odin, Per (author)
- Lund University,Lunds universitet,Restorative Parkinson Unit,Forskargrupper vid Lunds universitet,Lund University Research Groups,Central Hospital Bremerhaven
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- Fonoff, Erich Talamoni (author)
- Syrian-Lebanese Hospital,University of São Paulo
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- Fink, Gereon R. (author)
- Jülich Research Centre,University Hospital of Cologne
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- Henriksen, Tove (author)
- Bispebjerg Hospital
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- Ebersbach, Georg (author)
- Kliniken Beelitz GmbH
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- Pirtošek, Zvezdan (author)
- University Medical Centre Ljubljana
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- Visser-Vandewalle, Veerle (author)
- University Hospital of Cologne
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- Antonini, Angelo (author)
- University of Padova,San Camillo Hospital
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- Timmermann, Lars (author)
- University Hospital of Cologne,University Hospital Giessen and Marburg
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- Ray Chaudhuri, K. (author)
- King's College London,King's College Hospital
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(creator_code:org_t)
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- 2019-02-04
- 2019
- English.
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In: Movement Disorders. - : Wiley. - 0885-3185 .- 1531-8257.
- Related links:
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http://dx.doi.org/10...
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https://movementdiso...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Objective: Real-life observational report of clinical efficacy of bilateral subthalamic stimulation (STN-DBS), apomorphine (APO), and intrajejunal levodopa infusion (IJLI) on quality of life, motor, and nonmotor symptoms (NMS) in Parkinson's disease (PD). Methods: In this prospective, multicenter, international, real-life cohort observation study of 173 PD patients undergoing STN-DBS (n = 101), IJLI (n = 33), or APO (n = 39) were followed-up using PDQuestionnaire-8, NMSScale (NMSS), Unified PD Rating Scale (UPDRS)-III, UPDRS-IV, and levodopa equivalent daily dose (LEDD) before and 6 months after intervention. Outcome changes were analyzed with Wilcoxon signed-rank or paired t test when parametric tests were applicable. Multiple comparisons were corrected (multiple treatments/scales). Effect strengths were quantified with relative changes, effect size, and number needed to treat. Analyses were computed before and after propensity score matching, balancing demographic and clinical characteristics. Results: In all groups, PDQuestionnaire-8, UPDRS-IV, and NMSS total scores improved significantly at follow-up. Levodopa equivalent daily dose was significantly reduced after STN-DBS. Explorative NMSS domain analyses resulted in distinct profiles: STN-DBS improved urinary/sexual functions, mood/cognition, sleep/fatigue, and the miscellaneous domain. IJLI improved the 3 latter domains and gastrointestinal symptoms. APO improved mood/cognition, perceptual problems/hallucinations, attention/memory, and the miscellaneous domain. Overall, STN-DBS and IJLI seemed favorable for NMSS total score, and APO favorable for neuropsychological/neuropsychiatric NMS and PDQuestionnaire-8 outcome. Conclusions: This is the first comparison of quality of life, nonmotor. and motor outcomes in PD patients undergoing STN-DBS, IJLI, and APO in a real-life cohort. Distinct effect profiles were identified for each treatment option. Our results highlight the importance of holistic nonmotor and motor symptoms assessments to personalize treatment choices.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Apomorphine
- Deep brain stimulation
- Intrajejunal levodopa infusion
- Nonmotor symptoms
- Quality of life
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Dafsari, Haidar ...
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Martinez-Martin, ...
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Rizos, Alexandra
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Trost, Maja
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dos Santos Ghila ...
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Reddy, Prashanth
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show more...
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Sauerbier, Anna
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Petry-Schmelzer, ...
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Kramberger, Mili ...
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Borgemeester, Ro ...
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Barbe, Michael T ...
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Ashkan, Keyoumar ...
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Silverdale, Mont ...
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Evans, Julian
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Odin, Per
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Fonoff, Erich Ta ...
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Fink, Gereon R.
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Henriksen, Tove
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Ebersbach, Georg
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Pirtošek, Zvezda ...
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Visser-Vandewall ...
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Antonini, Angelo
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Timmermann, Lars
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Ray Chaudhuri, K ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Movement Disorde ...
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Lund University