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A Modified Progress...
A Modified Progressive Supranuclear Palsy Rating Scale
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- Grötsch, Marie Therese (författare)
- Technical University of Munich,German Center for Neurodegenerative Diseases (DZNE), Bonn
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- Respondek, Gesine (författare)
- Technical University of Munich,Hannover Medical School,German Center for Neurodegenerative Diseases (DZNE), Bonn
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- Colosimo, Carlo (författare)
- Santa Maria University Hospital
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- Compta, Yaroslau (författare)
- CIBER Enfermedades Neurodegenerativas (CIBERNED),Institutd' Investigacions Biomèdiques August Pi iSunyer (IDIBAPS),University of Barcelona
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- Corvol, Jean Christophe (författare)
- Paris-Sorbonne University,Pitié-Salpêtrière University Hospital
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- Ferreira, Joaquim (författare)
- University of Lisbon
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- Huber, Meret Koroni (författare)
- Hannover Medical School
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- Klietz, Martin (författare)
- Hannover Medical School
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- Krey, Lea F.M. (författare)
- Hannover Medical School
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- Levin, Johannes (författare)
- German Center for Neurodegenerative Diseases (DZNE), Bonn,Ludwig-Maximilian University of Munich
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- Jecmenica-Lukic, Milica (författare)
- Clinical Center of Serbia
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- Macías-García, Daniel (författare)
- University Hospital Virgen del Rocío,University of Seville
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- Meissner, Wassilios G. (författare)
- Groupe Hospitalier Pellegrin,University of Otago,University of Bordeaux
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- Mir, Pablo (författare)
- University Hospital Virgen del Rocío,University of Seville,CIBER Enfermedades Neurodegenerativas (CIBERNED)
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- Morris, Huw (författare)
- University College London
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- Nilsson, Christer (författare)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
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- Rowe, James B. (författare)
- University of Cambridge
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- Seppi, Klaus (författare)
- Medical University of Innsbruck
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- Stamelou, Maria (författare)
- Philipp University of Marburg,Hygeia Hospital,European University Cyprus
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- van Swieten, John C. (författare)
- Erasmus University Medical Center
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- Wenning, Gregor (författare)
- Medical University of Innsbruck
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- Del Ser, Teodoro (författare)
- Carlos III Health Institute
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- Golbe, Lawrence I. (författare)
- Rutgers University: The State University of New Jersey
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- Höglinger, Günter U. (författare)
- Technical University of Munich,Hannover Medical School,German Center for Neurodegenerative Diseases (DZNE), Bonn
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(creator_code:org_t)
- 2021-01-29
- 2021
- Engelska 13 s.
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Ingår i: Movement Disorders. - : Wiley. - 0885-3185 .- 1531-8257. ; 36:5, s. 1203-1215
- Relaterad länk:
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http://dx.doi.org/10...
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https://onlinelibrar...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: The Progressive Supranuclear Palsy Rating Scale is a prospectively validated physician-rated measure of disease severity for progressive supranuclear palsy. We hypothesized that, according to experts' opinion, individual scores of items would differ in relevance for patients' quality of life, functionality in daily living, and mortality. Thus, changes in the score may not equate to clinically meaningful changes in the patient's status. Objective: The aim of this work was to establish a condensed modified version of the scale focusing on meaningful disease milestones. Methods: Sixteen movement disorders experts evaluated each scale item for its capacity to capture disease milestones (0 = no, 1 = moderate, 2 = severe milestone). Items not capturing severe milestones were eliminated. Remaining items were recalibrated in proportion to milestone severity by collapsing across response categories that yielded identical milestone severity grades. Items with low sensitivity to change were eliminated, based on power calculations using longitudinal 12-month follow-up data from 86 patients with possible or probable progressive supranuclear palsy. Results: The modified scale retained 14 items (yielding 0–2 points each). The items were rated as functionally relevant to disease milestones with comparable severity. The modified scale was sensitive to change over 6 and 12 months and of similar power for clinical trials of disease-modifying therapy as the original scale (achieving 80% power for two-sample t test to detect a 50% slowing with n = 41 and 25% slowing with n = 159 at 12 months). Conclusions: The modified Progressive Supranuclear Palsy Rating Scale may serve as a clinimetrically sound scale to monitor disease progression in clinical trials and routine.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- clinical meaningfulness
- progressive supranuclear palsy
- rating scale
- sensitivity to change
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Grötsch, Marie T ...
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Respondek, Gesin ...
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Colosimo, Carlo
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Compta, Yaroslau
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Corvol, Jean Chr ...
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Ferreira, Joaqui ...
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visa fler...
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Huber, Meret Kor ...
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Klietz, Martin
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Krey, Lea F.M.
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Levin, Johannes
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Jecmenica-Lukic, ...
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Macías-García, D ...
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Meissner, Wassil ...
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Mir, Pablo
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Morris, Huw
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Nilsson, Christe ...
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Rowe, James B.
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Seppi, Klaus
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Stamelou, Maria
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van Swieten, Joh ...
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Wenning, Gregor
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Del Ser, Teodoro
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Golbe, Lawrence ...
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Höglinger, Günte ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
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Movement Disorde ...
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Lunds universitet