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Higher burden of su...
Higher burden of supraventricular ectopic complexes early after catheter ablation for atrial fibrillation is associated with increased risk of recurrent atrial fibrillation
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- Alhede, Christina (author)
- Herlev Gentofte University Hospital, Denmark
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- Johannessen, Arne (author)
- Herlev Gentofte University Hospital, Denmark
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- Dixen, Ulrik (author)
- Hvidovre University Hospital, Denmark
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- Jensen, Jan S. (author)
- Herlev Gentofte University Hospital, Denmark
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- Raatikainen, Pekka (author)
- Helsinki University Hospital, Finland
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- Hindricks, Gerhard (author)
- Leipzig University Hospital, Germany
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- Walfridsson, Håkan (author)
- Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US
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- Kongstad, Ole (author)
- Lund University Hospital, Sweden
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- Pehrson, Steen (author)
- Rigshosp, Denmark
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- Englund, Anders (author)
- Örebro University Hospital, Sweden
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- Hartikainen, Juha (author)
- Kupio University Hospital, Finland
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- Hansen, Peter S. (author)
- Varde Heart Centre, Denmark
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- Nielsen, Jens C. (author)
- Aarhus University Hospital, Denmark
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- Jons, Christian (author)
- Rigshosp, Denmark
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(creator_code:org_t)
- 2016-12-07
- 2018
- English.
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In: Europace. - : OXFORD UNIV PRESS. - 1099-5129 .- 1532-2092. ; 20:1, s. 50-57
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Abstract
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- Aims Early identification of patients who could benefit from early re-intervention after catheter ablation is highly warranted. Our aim was to investigate the association between post-procedural burden of supraventricular ectopic complexes (SVEC) and the risk of long-term atrial fibrillation (AF) recurrence. Methods and results A total of 125 patients undergoing catheter ablation for AF were included. Patients underwent 7-day Holter recordings immediately post-procedural. The number of SVEC in post-procedural Holter recordings was categorized into quartiles: 0-72, 73-212, 213-782 and amp;gt;= 783 SVEC/day. Long-term AF recurrence was defined as a combined endpoint of AF amp;gt;= 1 min during follow-up Holter recordings, cardioversion or hospitalization for AF after a 3-month blanking period and within 24 months of follow-up. High post-procedural supraventricular ectopy burden was associated with an increased risk of long-term AF recurrence in a dose-dependent manner (amp;gt;= 783 SVEC: HR 4.6 [1.9-11.5], P amp;lt; 0.001) irrespective of AF recurrence during the blanking period or other risk factors. In patients with early AF recurrence amp;lt; 90 days after catheter ablation ectopy burden was also highly predictive of long-term AF recurrence (SVEC amp;gt;= 213: HR 3.0 [1.3-6.7], P = 0.007). Correspondingly, patients with early AF recurrence but low ectopy burden remained at low risk of long-term AF recurrence after the blanking period. Conclusion Our results indicate that post-procedural ectopy burden is highly associated with long-term AF recurrence and could be a potent risk marker for selection of patients for early re-ablation. Development of future ablation risk stratification and strategies should include focus on post-procedural ectopy burden.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Arrhythmia; Atrial fibrillation; Treatment; Recurrence; Atrial premature complexes
Publication and Content Type
- ref (subject category)
- art (subject category)
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Alhede, Christin ...
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Johannessen, Arn ...
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Dixen, Ulrik
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Jensen, Jan S.
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Raatikainen, Pek ...
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Hindricks, Gerha ...
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Walfridsson, Håk ...
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Kongstad, Ole
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Pehrson, Steen
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Englund, Anders
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Hartikainen, Juh ...
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Hansen, Peter S.
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Nielsen, Jens C.
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Jons, Christian
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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Europace
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Linköping University