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Perivascular spaces...
Perivascular spaces, plasma GFAP, and speeded executive function in neurodegenerative diseases
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Andriuta, Daniela (author)
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Ottoy, Julie (author)
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Ruthirakuhan, Myuri (author)
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show more...
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Feliciano, Ginelle (author)
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Dilliott, Allison A. (author)
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Hegele, Robert A. (author)
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Gao, Fuqiang (author)
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McLaughlin, Paula M. (author)
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Rabin, Jennifer S. (author)
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Alexander, Madeline Wood (author)
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Scott, Christopher J. M. (author)
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Yhap, Vanessa (author)
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Berezuk, Courtney (author)
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Ozzoude, Miracle (author)
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Swardfager, Walter (author)
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Zebarth, Julia (author)
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Tartaglia, M. Carmela (author)
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Rogaeva, Ekaterina (author)
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Tang-Wai, David F. (author)
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Casaubon, Leanne (author)
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Kumar, Sanjeev (author)
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Dowlatshahi, Dar (author)
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Mandzia, Jennifer (author)
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Sahlas, Demetrios (author)
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Saposnik, Gustavo (author)
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Fischer, Corinne E. (author)
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Borrie, Michael (author)
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Hassan, Ayman (author)
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Binns, Malcolm A. (author)
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Freedman, Morris (author)
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Chertkow, Howard (author)
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Finger, Elizabeth (author)
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Frank, Andrew (author)
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Bartha, Robert (author)
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Symons, Sean (author)
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Swartz, Richard H. (author)
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Masellis, Mario (author)
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Black, Sandra E. (author)
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Ramirez, Joel (author)
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: ALZHEIMERS & DEMENTIA. - 1552-5260 .- 1552-5279.
- Related links:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- INTRODUCTIONWe investigated the effect of perivascular spaces (PVS) volume on speeded executive function (sEF), as mediated by white matter hyperintensities (WMH) volume and plasma glial fibrillary acidic protein (GFAP) in neurodegenerative diseases.METHODSA mediation analysis was performed to assess the relationship between neuroimaging markers and plasma biomarkers on sEF in 333 participants clinically diagnosed with Alzheimer's disease/mild cognitive impairment, frontotemporal dementia, or cerebrovascular disease from the Ontario Neurodegenerative Disease Research Initiative.RESULTSPVS was significantly associated with sEF (c = -0.125 +/- 0.054, 95% bootstrap confidence interval [CI] [-0.2309, -0.0189], p = 0.021). This effect was mediated by both GFAP and WMH.DISCUSSIONIn this unique clinical cohort of neurodegenerative diseases, we demonstrated that the effect of PVS on sEF was mediated by the presence of elevated plasma GFAP and white matter disease. These findings highlight the potential utility of imaging and plasma biomarkers in the current landscape of therapeutics targeting dementia.HIGHLIGHTS Perivascular spaces (PVS) and white matter hyperintensities (WMH) are imaging markers of small vessel disease. Plasma glial fibrillary protein acidic protein (GFAP) is a biomarker of astroglial injury. PVS, WMH, and GFAP are relevant in executive dysfunction from neurodegeneration. PVS's effect on executive function was mediated by GFAP and white matter disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- cerebrovascular diseases
- executive function
- neurodegenerative diseases
- perivascular spaces
- plasma glial fibrillary acidic protein
- white matter hyperintensities
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Andriuta, Daniel ...
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Ottoy, Julie
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Ruthirakuhan, My ...
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Feliciano, Ginel ...
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Dilliott, Alliso ...
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Hegele, Robert A ...
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show more...
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Gao, Fuqiang
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McLaughlin, Paul ...
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Rabin, Jennifer ...
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Alexander, Madel ...
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Scott, Christoph ...
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Yhap, Vanessa
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Berezuk, Courtne ...
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Ozzoude, Miracle
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Swardfager, Walt ...
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Zebarth, Julia
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Tartaglia, M. Ca ...
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Rogaeva, Ekateri ...
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Tang-Wai, David ...
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Casaubon, Leanne
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Kumar, Sanjeev
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Dowlatshahi, Dar
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Mandzia, Jennife ...
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Sahlas, Demetrio ...
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Saposnik, Gustav ...
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Fischer, Corinne ...
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Borrie, Michael
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Hassan, Ayman
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Binns, Malcolm A ...
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Freedman, Morris
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Chertkow, Howard
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Finger, Elizabet ...
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Frank, Andrew
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Bartha, Robert
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Symons, Sean
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Zetterberg, Henr ...
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Swartz, Richard ...
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Masellis, Mario
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Black, Sandra E.
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Ramirez, Joel
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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ALZHEIMERS & DEM ...
- By the university
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University of Gothenburg