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Sentinel node-assis...
Sentinel node-assisted neck dissection in advanced oral squamous cell carcinoma - A new protocol for staging and treatment
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- Bark, Rusana (författare)
- Karolinska Institutet
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- Kolev, Aeneas (författare)
- Karolinska Institutet
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- Elliot, Alexandra (författare)
- Karolinska Institutet
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- Piersiala, Krzysztof (författare)
- Karolinska Institutet
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- Näsman, Anders (författare)
- Karolinska Institutet
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- Grybäck, Per (författare)
- Karolinska Institutet
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- Georén, Susanna Kumlien (författare)
- Karolinska Institutet
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- Wendt, Malin (författare)
- Karolinska Institutet
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- Cardell, Lars Olaf (författare)
- Karolinska Institutet
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- Margolin, Gregori (författare)
- Karolinska Inst, Dept Clin Sci Intervent & Technol, Div ENT Dis, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Head & Neck Surg, Med Unit Head Neck Lung & Skin Canc, S-17176 Stockholm, Sweden.
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- Marklund, Linda (författare)
- Karolinska Institutet,Uppsala universitet,Öron-, näs- och halssjukdomar,Karolinska Inst, Dept Clin Sci Intervent & Technol, Div ENT Dis, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Head & Neck Surg, Med Unit Head Neck Lung & Skin Canc, S-17176 Stockholm, Sweden.
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Karolinska Institutet Karolinska Inst, Dept Clin Sci Intervent & Technol, Div ENT Dis, Stockholm, Sweden;Karolinska Univ Hosp, Dept Head & Neck Surg, Med Unit Head Neck Lung & Skin Canc, S-17176 Stockholm, Sweden. (creator_code:org_t)
- Wiley-Blackwell, 2023
- 2023
- Engelska.
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Ingår i: Cancer Medicine. - : Wiley-Blackwell. - 2045-7634. ; 12:11, s. 12524-12534
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: Sentinel lymph node biopsy (SLNB) is used to improve the staging of and guide treatment in patients with early-stage T1-T2 N0 oral squamous cell carcinoma (OSCC). The role of sentinel nodes (SNs) and the use of SN-technique in advanced OSCC (T3-T4 and/or N+) remain to be evaluated. This study investigates the nodal drainage and the rate of positive SNs (SNs+) in all stages of OSCC.Materials and Methods: In total, 85 patients with T1-T4 OSCC diagnosed 2019-2021 were included. We used a prolonged interval between peritumoral injection of radionuclide and SPECT-CT to include all SNs.Results: Patients with advanced OSCC presented a higher proportion of contralateral lymphatic drainage and a higher rate of SN+ compared to patients with early-stage disease. T3-T4 and N+ tumors presented a tendency for a higher rate of contralateral lymphatic drainage compared to T1-T2 and N0 tumors (p = 0.1). The prevalence of positive nodes (SNs+) was higher among patients with advanced disease, T3-T4 versus T1-T2 (p = 0.0398).Conclusion: SN-assisted ND enables identification and removal of all SNs + and has the potential for more accurate staging and could possibly give prognostic advantages regarding regional recurrence for all OSCC patients, especially among those with advanced disease. The precise localization of the SNs + also suggests that a more individualized ND approach might be possible in the future even for patients with advanced OSCC.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Nyckelord
- head and neck cancer
- metastases
- neck dissection
- oral squamous cell carcinoma
- sentinel node biopsy
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Bark, Rusana
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Kolev, Aeneas
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Elliot, Alexandr ...
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Piersiala, Krzys ...
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Näsman, Anders
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Grybäck, Per
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visa fler...
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Georén, Susanna ...
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Wendt, Malin
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Cardell, Lars Ol ...
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Margolin, Gregor ...
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Marklund, Linda
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kirurgi
- Artiklar i publikationen
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Cancer Medicine
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet